Urine calcium excretion predicts bone loss in idiopathic hypercalciuria
Although idiopathic hypercalciuria (IH) is associated with reduced bone mineral density (BMD), no studies to date have identified predictors of BMD change over an extended period of observation. We have studied change in femoral neck and spine BMD z-scores in men and women with IH and stone disease...
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| Veröffentlicht in: | Kidney international 2006-10, Vol.70 (8), p.1463-1467 |
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| description | Although idiopathic hypercalciuria (IH) is associated with reduced bone mineral density (BMD), no studies to date have identified predictors of BMD change over an extended period of observation. We have studied change in femoral neck and spine BMD z-scores in men and women with IH and stone disease (IHSF) and their first-degree relatives in order to determine the predictive value of commonly made clinical measurements. Urine calcium excretion was inversely correlated with change in femoral neck z-score over 3 years, and marginally correlated with fall in spine z-score. Markers of bone turnover, serum calcitriol, and urine measurements of acid–base balance such as ammonium and sulfate had no predictive value, nor did calcium intake assessed using a well-established questionnaire. It would appear that IHSF with the highest 24-h urine calcium excretion rates are at highest risk for loss of femoral neck bone mineral over a 3-year period. |
| doi_str_mv | 10.1038/sj.ki.5001778 |
| format | Article |
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We have studied change in femoral neck and spine BMD z-scores in men and women with IH and stone disease (IHSF) and their first-degree relatives in order to determine the predictive value of commonly made clinical measurements. Urine calcium excretion was inversely correlated with change in femoral neck z-score over 3 years, and marginally correlated with fall in spine z-score. Markers of bone turnover, serum calcitriol, and urine measurements of acid–base balance such as ammonium and sulfate had no predictive value, nor did calcium intake assessed using a well-established questionnaire. It would appear that IHSF with the highest 24-h urine calcium excretion rates are at highest risk for loss of femoral neck bone mineral over a 3-year period.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1038/sj.ki.5001778</identifier><identifier>PMID: 16941029</identifier><identifier>CODEN: KDYIA5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Absorptiometry, Photon ; Adult ; Aged ; Alkaline Phosphatase - blood ; Biological and medical sciences ; Bone and Bones - metabolism ; Bone and Bones - physiopathology ; Bone Density - physiology ; bone resorption ; Bone Resorption - blood ; Bone Resorption - physiopathology ; Bone Resorption - urine ; bone turnover ; calcitriol ; Calcitriol - blood ; Calcium - urine ; Cohort Studies ; Collagen - blood ; Diseases of the osteoarticular system ; Female ; Femur Neck - metabolism ; Femur Neck - physiopathology ; Humans ; Hydroxyproline - blood ; Male ; Medical sciences ; Middle Aged ; nephrolithiasis ; Nephrology. Urinary tract diseases ; osteopenia ; Osteoporosis. Osteomalacia. Paget disease ; Predictive Value of Tests ; Prospective Studies ; Quaternary Ammonium Compounds - urine ; Spine - metabolism ; Spine - physiopathology ; telopeptide ; Urinary lithiasis</subject><ispartof>Kidney international, 2006-10, Vol.70 (8), p.1463-1467</ispartof><rights>2006 International Society of Nephrology</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Oct 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-f5757780cea35bfe4a8d65e729e2b67d238c6235718159791d18075969bc240e3</citedby><cites>FETCH-LOGICAL-c489t-f5757780cea35bfe4a8d65e729e2b67d238c6235718159791d18075969bc240e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/210173487?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64387,64389,72341</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18229235$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16941029$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Asplin, J.R.</creatorcontrib><creatorcontrib>Donahue, S.</creatorcontrib><creatorcontrib>Kinder, J.</creatorcontrib><creatorcontrib>Coe, F.L.</creatorcontrib><title>Urine calcium excretion predicts bone loss in idiopathic hypercalciuria</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>Although idiopathic hypercalciuria (IH) is associated with reduced bone mineral density (BMD), no studies to date have identified predictors of BMD change over an extended period of observation. We have studied change in femoral neck and spine BMD z-scores in men and women with IH and stone disease (IHSF) and their first-degree relatives in order to determine the predictive value of commonly made clinical measurements. Urine calcium excretion was inversely correlated with change in femoral neck z-score over 3 years, and marginally correlated with fall in spine z-score. Markers of bone turnover, serum calcitriol, and urine measurements of acid–base balance such as ammonium and sulfate had no predictive value, nor did calcium intake assessed using a well-established questionnaire. It would appear that IHSF with the highest 24-h urine calcium excretion rates are at highest risk for loss of femoral neck bone mineral over a 3-year period.</description><subject>Absorptiometry, Photon</subject><subject>Adult</subject><subject>Aged</subject><subject>Alkaline Phosphatase - blood</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - metabolism</subject><subject>Bone and Bones - physiopathology</subject><subject>Bone Density - physiology</subject><subject>bone resorption</subject><subject>Bone Resorption - blood</subject><subject>Bone Resorption - physiopathology</subject><subject>Bone Resorption - urine</subject><subject>bone turnover</subject><subject>calcitriol</subject><subject>Calcitriol - blood</subject><subject>Calcium - urine</subject><subject>Cohort Studies</subject><subject>Collagen - blood</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Femur Neck - metabolism</subject><subject>Femur Neck - physiopathology</subject><subject>Humans</subject><subject>Hydroxyproline - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>nephrolithiasis</subject><subject>Nephrology. Urinary tract diseases</subject><subject>osteopenia</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Quaternary Ammonium Compounds - urine</subject><subject>Spine - metabolism</subject><subject>Spine - physiopathology</subject><subject>telopeptide</subject><subject>Urinary lithiasis</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp90U1r3DAQBmARUpJtmmOOLabQ9OSNPixLOpbQJIVAL81ZyPKYzMZrO5Jduv--WmyyEEhOQujRaPQOIReMrhkV-ipu1k-4lpQypfQRWTHJRc6UlMdkRamWOZdCn5KPMW5o2htBT8gpK03BKDcrcvsQsIPMu9bjtM3gnw8wYt9lQ4Aa_Rizqk_nbR9jhl2GNfaDGx_RZ4-7AcJ8L6D7RD40ro1wvqxn5OHm55_ru_z-9-2v6x_3uS-0GfNGKpn6pB6ckFUDhdN1KUFxA7wqVc2F9iUXUjHNpFGG1UxTJU1pKs8LCuKMfJ_rDqF_niCOdovRQ9u6DvopWq32WiqR5OW7stxnUZY0wa-v4KafQpd-YTlLsYpCq4TyGfmQogjQ2CHg1oWdZdTuB2Hjxj6hXQaR_Jel6FRtoT7oJfkEvi3AxZRiE1znMR6c5tykIJL7PLvOjVOAF3B4SM3nkFL_ixBs9AidT9ML4Edb9_hGi_8B9H2r9g</recordid><startdate>20061001</startdate><enddate>20061001</enddate><creator>Asplin, J.R.</creator><creator>Donahue, S.</creator><creator>Kinder, J.</creator><creator>Coe, F.L.</creator><general>Elsevier Inc</general><general>Nature Publishing</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20061001</creationdate><title>Urine calcium excretion predicts bone loss in idiopathic hypercalciuria</title><author>Asplin, J.R. ; Donahue, S. ; Kinder, J. ; Coe, F.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-f5757780cea35bfe4a8d65e729e2b67d238c6235718159791d18075969bc240e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Absorptiometry, Photon</topic><topic>Adult</topic><topic>Aged</topic><topic>Alkaline Phosphatase - blood</topic><topic>Biological and medical sciences</topic><topic>Bone and Bones - metabolism</topic><topic>Bone and Bones - physiopathology</topic><topic>Bone Density - physiology</topic><topic>bone resorption</topic><topic>Bone Resorption - blood</topic><topic>Bone Resorption - physiopathology</topic><topic>Bone Resorption - urine</topic><topic>bone turnover</topic><topic>calcitriol</topic><topic>Calcitriol - blood</topic><topic>Calcium - urine</topic><topic>Cohort Studies</topic><topic>Collagen - blood</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Femur Neck - metabolism</topic><topic>Femur Neck - physiopathology</topic><topic>Humans</topic><topic>Hydroxyproline - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>nephrolithiasis</topic><topic>Nephrology. Urinary tract diseases</topic><topic>osteopenia</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Quaternary Ammonium Compounds - urine</topic><topic>Spine - metabolism</topic><topic>Spine - physiopathology</topic><topic>telopeptide</topic><topic>Urinary lithiasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asplin, J.R.</creatorcontrib><creatorcontrib>Donahue, S.</creatorcontrib><creatorcontrib>Kinder, J.</creatorcontrib><creatorcontrib>Coe, F.L.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asplin, J.R.</au><au>Donahue, S.</au><au>Kinder, J.</au><au>Coe, F.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urine calcium excretion predicts bone loss in idiopathic hypercalciuria</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>2006-10-01</date><risdate>2006</risdate><volume>70</volume><issue>8</issue><spage>1463</spage><epage>1467</epage><pages>1463-1467</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><coden>KDYIA5</coden><abstract>Although idiopathic hypercalciuria (IH) is associated with reduced bone mineral density (BMD), no studies to date have identified predictors of BMD change over an extended period of observation. We have studied change in femoral neck and spine BMD z-scores in men and women with IH and stone disease (IHSF) and their first-degree relatives in order to determine the predictive value of commonly made clinical measurements. Urine calcium excretion was inversely correlated with change in femoral neck z-score over 3 years, and marginally correlated with fall in spine z-score. Markers of bone turnover, serum calcitriol, and urine measurements of acid–base balance such as ammonium and sulfate had no predictive value, nor did calcium intake assessed using a well-established questionnaire. It would appear that IHSF with the highest 24-h urine calcium excretion rates are at highest risk for loss of femoral neck bone mineral over a 3-year period.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16941029</pmid><doi>10.1038/sj.ki.5001778</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Absorptiometry, Photon Adult Aged Alkaline Phosphatase - blood Biological and medical sciences Bone and Bones - metabolism Bone and Bones - physiopathology Bone Density - physiology bone resorption Bone Resorption - blood Bone Resorption - physiopathology Bone Resorption - urine bone turnover calcitriol Calcitriol - blood Calcium - urine Cohort Studies Collagen - blood Diseases of the osteoarticular system Female Femur Neck - metabolism Femur Neck - physiopathology Humans Hydroxyproline - blood Male Medical sciences Middle Aged nephrolithiasis Nephrology. Urinary tract diseases osteopenia Osteoporosis. Osteomalacia. Paget disease Predictive Value of Tests Prospective Studies Quaternary Ammonium Compounds - urine Spine - metabolism Spine - physiopathology telopeptide Urinary lithiasis |
| title | Urine calcium excretion predicts bone loss in idiopathic hypercalciuria |
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