GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI
The human anterior cingulate cortex (ACC) is part of the default-mode network that shows predominant negative blood oxygen level–dependent (BOLD) responses in functional magnetic resonance imaging (fMRI). We combined fMRI during emotional processing and resting-state magnetic resonance spectroscopy...
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| Veröffentlicht in: | Nature neuroscience 2007-12, Vol.10 (12), p.1515-1517 |
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| creator | Northoff, Georg Walter, Martin Schulte, Rolf F Beck, Johannes Dydak, Ulrike Henning, Anke Boeker, Heinz Grimm, Simone Boesiger, Peter |
| description | The human anterior cingulate cortex (ACC) is part of the default-mode network that shows predominant negative blood oxygen level–dependent (BOLD) responses in functional magnetic resonance imaging (fMRI). We combined fMRI during emotional processing and resting-state magnetic resonance spectroscopy measurements and observed that the concentration of GABA in the ACC specifically correlated with the amount of negative BOLD responses in the very same region. Our findings show that default-mode network negative BOLD responses during emotions are mediated by GABA. |
| doi_str_mv | 10.1038/nn2001 |
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We combined fMRI during emotional processing and resting-state magnetic resonance spectroscopy measurements and observed that the concentration of GABA in the ACC specifically correlated with the amount of negative BOLD responses in the very same region. Our findings show that default-mode network negative BOLD responses during emotions are mediated by GABA.</description><identifier>ISSN: 1097-6256</identifier><identifier>EISSN: 1546-1726</identifier><identifier>DOI: 10.1038/nn2001</identifier><identifier>PMID: 17982452</identifier><identifier>CODEN: NANEFN</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Adult ; Animal Genetics and Genomics ; Behavioral Sciences ; Biological Techniques ; Biomedical and Life Sciences ; Biomedicine ; Blood Circulation - physiology ; Brain Mapping ; brief-communication ; Cerebral cortex ; Emotions ; Female ; GABA ; gamma-Aminobutyric Acid - metabolism ; Gyrus Cinguli - blood supply ; Gyrus Cinguli - metabolism ; Humans ; Image Processing, Computer-Assisted - methods ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy - methods ; Male ; Measurement ; Middle Aged ; Neurobiology ; Neurosciences ; Oxygen - blood ; Photic Stimulation ; Physiological aspects ; Rest ; Spectrum analysis</subject><ispartof>Nature neuroscience, 2007-12, Vol.10 (12), p.1515-1517</ispartof><rights>Springer Nature America, Inc. 2007</rights><rights>COPYRIGHT 2007 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Dec 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-d86824fdeaa25b0af4281d16e909457e560822df9af20ffb9a27c60b363de4e03</citedby><cites>FETCH-LOGICAL-c538t-d86824fdeaa25b0af4281d16e909457e560822df9af20ffb9a27c60b363de4e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nn2001$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nn2001$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17982452$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Northoff, Georg</creatorcontrib><creatorcontrib>Walter, Martin</creatorcontrib><creatorcontrib>Schulte, Rolf F</creatorcontrib><creatorcontrib>Beck, Johannes</creatorcontrib><creatorcontrib>Dydak, Ulrike</creatorcontrib><creatorcontrib>Henning, Anke</creatorcontrib><creatorcontrib>Boeker, Heinz</creatorcontrib><creatorcontrib>Grimm, Simone</creatorcontrib><creatorcontrib>Boesiger, Peter</creatorcontrib><title>GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI</title><title>Nature neuroscience</title><addtitle>Nat Neurosci</addtitle><addtitle>Nat Neurosci</addtitle><description>The human anterior cingulate cortex (ACC) is part of the default-mode network that shows predominant negative blood oxygen level–dependent (BOLD) responses in functional magnetic resonance imaging (fMRI). We combined fMRI during emotional processing and resting-state magnetic resonance spectroscopy measurements and observed that the concentration of GABA in the ACC specifically correlated with the amount of negative BOLD responses in the very same region. Our findings show that default-mode network negative BOLD responses during emotions are mediated by GABA.</description><subject>Adult</subject><subject>Animal Genetics and Genomics</subject><subject>Behavioral Sciences</subject><subject>Biological Techniques</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood Circulation - physiology</subject><subject>Brain Mapping</subject><subject>brief-communication</subject><subject>Cerebral cortex</subject><subject>Emotions</subject><subject>Female</subject><subject>GABA</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Gyrus Cinguli - blood supply</subject><subject>Gyrus Cinguli - metabolism</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Measurement</subject><subject>Middle Aged</subject><subject>Neurobiology</subject><subject>Neurosciences</subject><subject>Oxygen - 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Academic</collection><jtitle>Nature neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Northoff, Georg</au><au>Walter, Martin</au><au>Schulte, Rolf F</au><au>Beck, Johannes</au><au>Dydak, Ulrike</au><au>Henning, Anke</au><au>Boeker, Heinz</au><au>Grimm, Simone</au><au>Boesiger, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI</atitle><jtitle>Nature neuroscience</jtitle><stitle>Nat Neurosci</stitle><addtitle>Nat Neurosci</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>10</volume><issue>12</issue><spage>1515</spage><epage>1517</epage><pages>1515-1517</pages><issn>1097-6256</issn><eissn>1546-1726</eissn><coden>NANEFN</coden><abstract>The human anterior cingulate cortex (ACC) is part of the default-mode network that shows predominant negative blood oxygen level–dependent (BOLD) responses in functional magnetic resonance imaging (fMRI). We combined fMRI during emotional processing and resting-state magnetic resonance spectroscopy measurements and observed that the concentration of GABA in the ACC specifically correlated with the amount of negative BOLD responses in the very same region. Our findings show that default-mode network negative BOLD responses during emotions are mediated by GABA.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>17982452</pmid><doi>10.1038/nn2001</doi><tpages>3</tpages></addata></record> |
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| subjects | Adult Animal Genetics and Genomics Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Blood Circulation - physiology Brain Mapping brief-communication Cerebral cortex Emotions Female GABA gamma-Aminobutyric Acid - metabolism Gyrus Cinguli - blood supply Gyrus Cinguli - metabolism Humans Image Processing, Computer-Assisted - methods Magnetic Resonance Imaging Magnetic Resonance Spectroscopy - methods Male Measurement Middle Aged Neurobiology Neurosciences Oxygen - blood Photic Stimulation Physiological aspects Rest Spectrum analysis |
| title | GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI |
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