Absence of acetylcholinesterase at the neuromuscular junctions of perlecan-null mice

The collagen-tailed form of acetylcholinesterase (AChE) is concentrated at the vertebrate neuromuscular junction (NMJ), where it is responsible for rapidly terminating neurotransmission. This unique oligomeric form of AChE, consisting of three tetramers covalently attached to a collagen-like tail, i...

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Veröffentlicht in:	Nature neuroscience 2002-02, Vol.5 (2), p.119-123
Hauptverfasser:	Rotundo, Richard L, Yamada, Yoshihiko, Arikawa-Hirasawa, Eri, Rossi, Susana G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase - deficiency Acetylcholinesterase - metabolism Animal Genetics and Genomics Animals Antibodies Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Collagen Embryo, Mammalian - metabolism Enzymes Extracellular matrix Gene expression Genetic aspects Heparan sulfate Heparan Sulfate Proteoglycans - genetics Heparan Sulfate Proteoglycans - physiology Localization Mice - embryology Mice, Knockout - genetics Musculoskeletal system Neurobiology Neuromuscular Junction - embryology Neurosciences Physiological aspects Proteoglycans
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