Impaired in vivo dopamine release in parkin knockout mice

Abstract parkin is the most frequent causative gene among familial Parkinson's disease (PD). Although parkin deficiency induces autosomal recessive juvenile parkinsonism (AR-JP, PARK2) in humans, parkin knockout (PKO) mice consistently show few signs of dopaminergic degeneration. We aimed to di...

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Veröffentlicht in:	Brain research 2010-09, Vol.1352, p.214-222
Hauptverfasser:	Oyama, Genko, Yoshimi, Kenji, Natori, Shihoko, Chikaoka, Yoko, Ren, Yong-Ri, Funayama, Manabu, Shimo, Yasushi, Takahashi, Ryosuke, Nakazato, Taizo, Kitazawa, Shigeru, Hattori, Nobutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism Aging - physiology Animals Biological and medical sciences Body Weight Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Corpus Striatum - physiology Dopamine - metabolism Dopamine - secretion Dopamine release Fundamental and applied biological sciences. Psychology Homovanillic Acid - metabolism Hydroxyindoleacetic Acid - metabolism In vivo voltammetry Medial forebrain bundle Mice Mice, Knockout Motor Activity - physiology Nerve Fibers - drug effects Nerve Fibers - physiology Neurology Nomifensine - pharmacology parkin knockout mice Prosencephalon - drug effects Prosencephalon - physiology Ubiquitin-Protein Ligases - deficiency Vertebrates: nervous system and sense organs
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