Differential development of central dopaminergic and serotonergic systems in BALB/c and C57BL/6J mice
Abstract Although the etiology of autism is unclear, disruptions of the dopaminergic and serotonergic systems have been associated with the disorder. Based on behavioral differences observed in the BALB/c strain of mice in comparison to other strains, notably, C57BL/6J mice, it has been suggested th...
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description | Abstract Although the etiology of autism is unclear, disruptions of the dopaminergic and serotonergic systems have been associated with the disorder. Based on behavioral differences observed in the BALB/c strain of mice in comparison to other strains, notably, C57BL/6J mice, it has been suggested that the BALB/c strain may serve as an animal model of autism. However, to date, most work investigating neural and behavioral abnormalities in this strain has been performed in adult animals. Therefore, the present study was conducted to examine the development of the central dopaminergic and serotonergic systems of BALB/c mice as compared to C57BL/6J mice. Levels of dopamine, serotonin, and their metabolites in several different brain regions and at three ages during development were measured. Alterations in both monoaminergic systems associated with age and strain were detected across brain regions indicating that there are neurochemical differences between these strains early in life. However, despite these differences in the development of brain monoaminergic systems, it remains difficult to declare this strain as a valid model of autism. |
doi_str_mv | 10.1016/j.brainres.2010.06.031 |
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Based on behavioral differences observed in the BALB/c strain of mice in comparison to other strains, notably, C57BL/6J mice, it has been suggested that the BALB/c strain may serve as an animal model of autism. However, to date, most work investigating neural and behavioral abnormalities in this strain has been performed in adult animals. Therefore, the present study was conducted to examine the development of the central dopaminergic and serotonergic systems of BALB/c mice as compared to C57BL/6J mice. Levels of dopamine, serotonin, and their metabolites in several different brain regions and at three ages during development were measured. Alterations in both monoaminergic systems associated with age and strain were detected across brain regions indicating that there are neurochemical differences between these strains early in life. However, despite these differences in the development of brain monoaminergic systems, it remains difficult to declare this strain as a valid model of autism.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2010.06.031</identifier><identifier>PMID: 20599834</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis of Variance ; Animals ; Animals, Newborn ; Autism ; Biological and medical sciences ; Brain - growth & development ; Brain - metabolism ; Brain Chemistry - physiology ; Child clinical studies ; Chromatography, High Pressure Liquid - methods ; Developmental disorders ; Dopamine ; Dopamine - metabolism ; Electrochemistry - methods ; Female ; Infantile autism ; Male ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Neurology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-d0e565c69d3179f20cbade5bc7749a99992b013bb05169175852d2712d831f113</citedby><cites>FETCH-LOGICAL-c484t-d0e565c69d3179f20cbade5bc7749a99992b013bb05169175852d2712d831f113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.brainres.2010.06.031$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23165037$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20599834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yochum, Carrie L</creatorcontrib><creatorcontrib>Medvecky, Christopher M</creatorcontrib><creatorcontrib>Cheh, Michelle A</creatorcontrib><creatorcontrib>Bhattacharya, Prianka</creatorcontrib><creatorcontrib>Wagner, George C</creatorcontrib><title>Differential development of central dopaminergic and serotonergic systems in BALB/c and C57BL/6J mice</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Abstract Although the etiology of autism is unclear, disruptions of the dopaminergic and serotonergic systems have been associated with the disorder. Based on behavioral differences observed in the BALB/c strain of mice in comparison to other strains, notably, C57BL/6J mice, it has been suggested that the BALB/c strain may serve as an animal model of autism. However, to date, most work investigating neural and behavioral abnormalities in this strain has been performed in adult animals. Therefore, the present study was conducted to examine the development of the central dopaminergic and serotonergic systems of BALB/c mice as compared to C57BL/6J mice. Levels of dopamine, serotonin, and their metabolites in several different brain regions and at three ages during development were measured. Alterations in both monoaminergic systems associated with age and strain were detected across brain regions indicating that there are neurochemical differences between these strains early in life. However, despite these differences in the development of brain monoaminergic systems, it remains difficult to declare this strain as a valid model of autism.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Autism</subject><subject>Biological and medical sciences</subject><subject>Brain - growth & development</subject><subject>Brain - metabolism</subject><subject>Brain Chemistry - physiology</subject><subject>Child clinical studies</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Developmental disorders</subject><subject>Dopamine</subject><subject>Dopamine - metabolism</subject><subject>Electrochemistry - methods</subject><subject>Female</subject><subject>Infantile autism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Neurology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Serotonin</subject><subject>Serotonin - metabolism</subject><subject>Species Specificity</subject><subject>Strain difference</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2P0zAQhi0EYsvCX1jlgjilHduxHV8Q2y6fqsQBOFuOPUEuSVzsdKX-e1y1CxKX9WU0o2dmrPcdQm4oLClQudotu2TDlDAvGZQiyCVw-oQsaKtYLVkDT8kCAGTdas2vyIucdyXlXMNzcsVAaN3yZkHwLvQ9JpzmYIfK4z0OcT-WtIp95UpMp3Lc2zFMmH4GV9nJVxlTnOOlkI95xjFXYarWt9v16oxshFpvV_JLNQaHL8mz3g4ZX13iNfnx4f33zad6-_Xj583ttnZN28y1BxRSOKk9p0r3DFxnPYrOKdVoq8tjHVDedSCo1FSJVjDPFGW-5bSnlF-TN-e5-xR_HzDPZgzZ4TDYCeMhm1YpoVkrHydV02quG94UUp5Jl2LOCXuzT2G06WgomJMXZmcevDAnLwxIU7wojTeXFYduRP-37UH8Ary-ADY7O_TJTi7kfxynUgBXhXt35rBIdx8wmewCTg59SOhm42N4_C9v_xvhhjCFsvUXHjHv4iFNxRhDTWYGzLfT5ZwOh0LRWxa9_gBtar3l</recordid><startdate>20100819</startdate><enddate>20100819</enddate><creator>Yochum, Carrie L</creator><creator>Medvecky, Christopher M</creator><creator>Cheh, Michelle A</creator><creator>Bhattacharya, Prianka</creator><creator>Wagner, George C</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20100819</creationdate><title>Differential development of central dopaminergic and serotonergic systems in BALB/c and C57BL/6J mice</title><author>Yochum, Carrie L ; Medvecky, Christopher M ; Cheh, Michelle A ; Bhattacharya, Prianka ; Wagner, George C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-d0e565c69d3179f20cbade5bc7749a99992b013bb05169175852d2712d831f113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Autism</topic><topic>Biological and medical sciences</topic><topic>Brain - growth & development</topic><topic>Brain - metabolism</topic><topic>Brain Chemistry - physiology</topic><topic>Child clinical studies</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Developmental disorders</topic><topic>Dopamine</topic><topic>Dopamine - metabolism</topic><topic>Electrochemistry - methods</topic><topic>Female</topic><topic>Infantile autism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Neurology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Serotonin</topic><topic>Serotonin - metabolism</topic><topic>Species Specificity</topic><topic>Strain difference</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yochum, Carrie L</creatorcontrib><creatorcontrib>Medvecky, Christopher M</creatorcontrib><creatorcontrib>Cheh, Michelle A</creatorcontrib><creatorcontrib>Bhattacharya, Prianka</creatorcontrib><creatorcontrib>Wagner, George C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yochum, Carrie L</au><au>Medvecky, Christopher M</au><au>Cheh, Michelle A</au><au>Bhattacharya, Prianka</au><au>Wagner, George C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential development of central dopaminergic and serotonergic systems in BALB/c and C57BL/6J mice</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2010-08-19</date><risdate>2010</risdate><volume>1349</volume><spage>97</spage><epage>104</epage><pages>97-104</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Abstract Although the etiology of autism is unclear, disruptions of the dopaminergic and serotonergic systems have been associated with the disorder. Based on behavioral differences observed in the BALB/c strain of mice in comparison to other strains, notably, C57BL/6J mice, it has been suggested that the BALB/c strain may serve as an animal model of autism. However, to date, most work investigating neural and behavioral abnormalities in this strain has been performed in adult animals. Therefore, the present study was conducted to examine the development of the central dopaminergic and serotonergic systems of BALB/c mice as compared to C57BL/6J mice. Levels of dopamine, serotonin, and their metabolites in several different brain regions and at three ages during development were measured. Alterations in both monoaminergic systems associated with age and strain were detected across brain regions indicating that there are neurochemical differences between these strains early in life. 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subjects | Analysis of Variance Animals Animals, Newborn Autism Biological and medical sciences Brain - growth & development Brain - metabolism Brain Chemistry - physiology Child clinical studies Chromatography, High Pressure Liquid - methods Developmental disorders Dopamine Dopamine - metabolism Electrochemistry - methods Female Infantile autism Male Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Neurology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Serotonin Serotonin - metabolism Species Specificity Strain difference |
title | Differential development of central dopaminergic and serotonergic systems in BALB/c and C57BL/6J mice |
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