Differential development of central dopaminergic and serotonergic systems in BALB/c and C57BL/6J mice

Abstract Although the etiology of autism is unclear, disruptions of the dopaminergic and serotonergic systems have been associated with the disorder. Based on behavioral differences observed in the BALB/c strain of mice in comparison to other strains, notably, C57BL/6J mice, it has been suggested th...

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Veröffentlicht in:Brain research 2010-08, Vol.1349, p.97-104
Hauptverfasser: Yochum, Carrie L, Medvecky, Christopher M, Cheh, Michelle A, Bhattacharya, Prianka, Wagner, George C
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container_title Brain research
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creator Yochum, Carrie L
Medvecky, Christopher M
Cheh, Michelle A
Bhattacharya, Prianka
Wagner, George C
description Abstract Although the etiology of autism is unclear, disruptions of the dopaminergic and serotonergic systems have been associated with the disorder. Based on behavioral differences observed in the BALB/c strain of mice in comparison to other strains, notably, C57BL/6J mice, it has been suggested that the BALB/c strain may serve as an animal model of autism. However, to date, most work investigating neural and behavioral abnormalities in this strain has been performed in adult animals. Therefore, the present study was conducted to examine the development of the central dopaminergic and serotonergic systems of BALB/c mice as compared to C57BL/6J mice. Levels of dopamine, serotonin, and their metabolites in several different brain regions and at three ages during development were measured. Alterations in both monoaminergic systems associated with age and strain were detected across brain regions indicating that there are neurochemical differences between these strains early in life. However, despite these differences in the development of brain monoaminergic systems, it remains difficult to declare this strain as a valid model of autism.
doi_str_mv 10.1016/j.brainres.2010.06.031
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Psychiatry</subject><subject>Serotonin</subject><subject>Serotonin - metabolism</subject><subject>Species Specificity</subject><subject>Strain difference</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2P0zAQhi0EYsvCX1jlgjilHduxHV8Q2y6fqsQBOFuOPUEuSVzsdKX-e1y1CxKX9WU0o2dmrPcdQm4oLClQudotu2TDlDAvGZQiyCVw-oQsaKtYLVkDT8kCAGTdas2vyIucdyXlXMNzcsVAaN3yZkHwLvQ9JpzmYIfK4z0OcT-WtIp95UpMp3Lc2zFMmH4GV9nJVxlTnOOlkI95xjFXYarWt9v16oxshFpvV_JLNQaHL8mz3g4ZX13iNfnx4f33zad6-_Xj583ttnZN28y1BxRSOKk9p0r3DFxnPYrOKdVoq8tjHVDedSCo1FSJVjDPFGW-5bSnlF-TN-e5-xR_HzDPZgzZ4TDYCeMhm1YpoVkrHydV02quG94UUp5Jl2LOCXuzT2G06WgomJMXZmcevDAnLwxIU7wojTeXFYduRP-37UH8Ary-ADY7O_TJTi7kfxynUgBXhXt35rBIdx8wmewCTg59SOhm42N4_C9v_xvhhjCFsvUXHjHv4iFNxRhDTWYGzLfT5ZwOh0LRWxa9_gBtar3l</recordid><startdate>20100819</startdate><enddate>20100819</enddate><creator>Yochum, Carrie L</creator><creator>Medvecky, Christopher M</creator><creator>Cheh, Michelle A</creator><creator>Bhattacharya, Prianka</creator><creator>Wagner, George C</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20100819</creationdate><title>Differential development of central dopaminergic and serotonergic systems in BALB/c and C57BL/6J mice</title><author>Yochum, Carrie L ; Medvecky, Christopher M ; Cheh, Michelle A ; Bhattacharya, Prianka ; Wagner, George C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-d0e565c69d3179f20cbade5bc7749a99992b013bb05169175852d2712d831f113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Autism</topic><topic>Biological and medical sciences</topic><topic>Brain - growth &amp; development</topic><topic>Brain - metabolism</topic><topic>Brain Chemistry - physiology</topic><topic>Child clinical studies</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Developmental disorders</topic><topic>Dopamine</topic><topic>Dopamine - metabolism</topic><topic>Electrochemistry - methods</topic><topic>Female</topic><topic>Infantile autism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Neurology</topic><topic>Psychology. 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subjects Analysis of Variance
Animals
Animals, Newborn
Autism
Biological and medical sciences
Brain - growth & development
Brain - metabolism
Brain Chemistry - physiology
Child clinical studies
Chromatography, High Pressure Liquid - methods
Developmental disorders
Dopamine
Dopamine - metabolism
Electrochemistry - methods
Female
Infantile autism
Male
Medical sciences
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Neurology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Serotonin
Serotonin - metabolism
Species Specificity
Strain difference
title Differential development of central dopaminergic and serotonergic systems in BALB/c and C57BL/6J mice
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