The effect of calcitriol, paricalcitol, and a calcimimetic on extraosseous calcifications in uremic rats

Vitamin D derivatives and calcimimetics are used to treat secondary hyperparathyroidism in patients with chronic renal failure. We investigated the effect of calcitriol, paricalcitol, and the calcimimetic AMG 641 on soft-tissue calcification in uremic rats with secondary hyperparathyroidism. Control...

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Veröffentlicht in:	Kidney international 2008-02, Vol.73 (3), p.300-307
Hauptverfasser:	Lopez, I., Mendoza, F.J., Aguilera-Tejero, E., Perez, J., Guerrero, F., Martin, D., Rodriguez, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - metabolism Biological and medical sciences calcimimetic Calcinosis - complications Calcinosis - drug therapy Calcinosis - metabolism calcitriol Calcitriol - therapeutic use Calcium - metabolism Calcium Channel Agonists - therapeutic use Endocrinopathies Ergocalciferols - therapeutic use hyperparathyroidism Hyperparathyroidism, Secondary - complications Hyperparathyroidism, Secondary - drug therapy Hyperparathyroidism, Secondary - metabolism Male Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Non tumoral diseases. Target tissue resistance. Benign neoplasms Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases) paricalcitol Phosphorus - metabolism Rats Rats, Wistar Renal failure Uremia - complications Uremia - metabolism vascular calcification
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