Functional and neurochemical changes of the gastrointestinal tract in a rodent model of Parkinson's disease
Patients with Parkinson's disease develop motor disturbances often accompanied by peripheral autonomic dysfunctions, including gastrointestinal disorders, such as dysphagia, gastric stasis and constipation. While the mechanisms subserving enteric autonomic dysfunctions are not clearly understoo...
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| Veröffentlicht in: | Neuroscience letters 2009-12, Vol.467 (3), p.203-207 |
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| creator | Blandini, F. Balestra, B. Levandis, G. Cervio, M. Greco, R. Tassorelli, C. Colucci, M. Faniglione, M. Bazzini, E. Nappi, G. Clavenzani, P. Vigneri, S. De Giorgio, R. Tonini, M. |
| description | Patients with Parkinson's disease develop motor disturbances often accompanied by peripheral autonomic dysfunctions, including gastrointestinal disorders, such as dysphagia, gastric stasis and constipation. While the mechanisms subserving enteric autonomic dysfunctions are not clearly understood, they may involve the enteric dopaminergic and/or nitrergic systems. In the present study, we demonstrate that rats with unilateral 6-hydroxydopamine lesion of nigrostriatal dopaminergic neurons develop a marked inhibition of propulsive activity compared to sham-operated controls, as indicated by a 60% reduction of daily fecal output at the 4th week of observation. Immunohistochemical data revealed that 6-hydroxydopamine treatment did not affect the total number of HuC/D-positive myenteric neurons in both the proximal and distal segments of ileum and colon. Conversely, in the distal ileum and proximal colon the number of nitrergic neurons was significantly reduced. These results suggest that a disturbed distal gut transit, reminiscent of constipation in the clinical setting, may occur as a consequence of a reduced propulsive motility, likely due to an impairment of a nitric oxide-mediated descending inhibition during peristalsis. |
| doi_str_mv | 10.1016/j.neulet.2009.10.035 |
| format | Article |
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While the mechanisms subserving enteric autonomic dysfunctions are not clearly understood, they may involve the enteric dopaminergic and/or nitrergic systems. In the present study, we demonstrate that rats with unilateral 6-hydroxydopamine lesion of nigrostriatal dopaminergic neurons develop a marked inhibition of propulsive activity compared to sham-operated controls, as indicated by a 60% reduction of daily fecal output at the 4th week of observation. Immunohistochemical data revealed that 6-hydroxydopamine treatment did not affect the total number of HuC/D-positive myenteric neurons in both the proximal and distal segments of ileum and colon. Conversely, in the distal ileum and proximal colon the number of nitrergic neurons was significantly reduced. These results suggest that a disturbed distal gut transit, reminiscent of constipation in the clinical setting, may occur as a consequence of a reduced propulsive motility, likely due to an impairment of a nitric oxide-mediated descending inhibition during peristalsis.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2009.10.035</identifier><identifier>PMID: 19835930</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Colon - innervation ; Colon - physiopathology ; Constipation ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disease Models, Animal ; Enteric Nervous System - metabolism ; Enteric Nervous System - pathology ; Enteric Nervous System - physiopathology ; Enteric neurons ; Fundamental and applied biological sciences. Psychology ; Gastrointestinal Diseases - etiology ; Gastrointestinal Diseases - metabolism ; Gastrointestinal Diseases - physiopathology ; Gastrointestinal Motility - physiology ; Gut dysfunction ; Ileum - innervation ; Ileum - physiopathology ; Immunohistochemistry ; Male ; Medical sciences ; Neurology ; Neuronal Plasticity - physiology ; Neuroplasticity ; Nitrergic Neurons - metabolism ; Nitrergic Neurons - pathology ; Nitric oxide ; Nitric Oxide - metabolism ; Oxidopamine ; Parkinson Disease - complications ; Parkinsonian Disorders - complications ; Rats ; Rats, Sprague-Dawley ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2009-12, Vol.467 (3), p.203-207</ispartof><rights>2009 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-1066d737eab801a2c934a3fd9b0468ee9cc33b13f18bf956cfea8ece1c9534463</citedby><cites>FETCH-LOGICAL-c566t-1066d737eab801a2c934a3fd9b0468ee9cc33b13f18bf956cfea8ece1c9534463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030439400901355X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22155005$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19835930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blandini, F.</creatorcontrib><creatorcontrib>Balestra, B.</creatorcontrib><creatorcontrib>Levandis, G.</creatorcontrib><creatorcontrib>Cervio, M.</creatorcontrib><creatorcontrib>Greco, R.</creatorcontrib><creatorcontrib>Tassorelli, C.</creatorcontrib><creatorcontrib>Colucci, M.</creatorcontrib><creatorcontrib>Faniglione, M.</creatorcontrib><creatorcontrib>Bazzini, E.</creatorcontrib><creatorcontrib>Nappi, G.</creatorcontrib><creatorcontrib>Clavenzani, P.</creatorcontrib><creatorcontrib>Vigneri, S.</creatorcontrib><creatorcontrib>De Giorgio, R.</creatorcontrib><creatorcontrib>Tonini, M.</creatorcontrib><title>Functional and neurochemical changes of the gastrointestinal tract in a rodent model of Parkinson's disease</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Patients with Parkinson's disease develop motor disturbances often accompanied by peripheral autonomic dysfunctions, including gastrointestinal disorders, such as dysphagia, gastric stasis and constipation. While the mechanisms subserving enteric autonomic dysfunctions are not clearly understood, they may involve the enteric dopaminergic and/or nitrergic systems. In the present study, we demonstrate that rats with unilateral 6-hydroxydopamine lesion of nigrostriatal dopaminergic neurons develop a marked inhibition of propulsive activity compared to sham-operated controls, as indicated by a 60% reduction of daily fecal output at the 4th week of observation. Immunohistochemical data revealed that 6-hydroxydopamine treatment did not affect the total number of HuC/D-positive myenteric neurons in both the proximal and distal segments of ileum and colon. Conversely, in the distal ileum and proximal colon the number of nitrergic neurons was significantly reduced. These results suggest that a disturbed distal gut transit, reminiscent of constipation in the clinical setting, may occur as a consequence of a reduced propulsive motility, likely due to an impairment of a nitric oxide-mediated descending inhibition during peristalsis.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Colon - innervation</subject><subject>Colon - physiopathology</subject><subject>Constipation</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Disease Models, Animal</subject><subject>Enteric Nervous System - metabolism</subject><subject>Enteric Nervous System - pathology</subject><subject>Enteric Nervous System - physiopathology</subject><subject>Enteric neurons</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastrointestinal Diseases - etiology</subject><subject>Gastrointestinal Diseases - metabolism</subject><subject>Gastrointestinal Diseases - physiopathology</subject><subject>Gastrointestinal Motility - physiology</subject><subject>Gut dysfunction</subject><subject>Ileum - innervation</subject><subject>Ileum - physiopathology</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Neuronal Plasticity - physiology</subject><subject>Neuroplasticity</subject><subject>Nitrergic Neurons - metabolism</subject><subject>Nitrergic Neurons - pathology</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Oxidopamine</subject><subject>Parkinson Disease - complications</subject><subject>Parkinsonian Disorders - complications</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFq3DAQhkVpaTZp36AUXZqcvB1Zkm1dCiE0aSGQHNqzkOVxVhtbSiW5kLevzC7tLT0NDN__M8xHyAcGWwas-bzfelwmzNsaQJXVFrh8RTasa-uqVW39mmyAg6i4EnBCTlPaA4BkUrwlJ0x1XCoOG_J4vXibXfBmosYPtHTGYHc4O1s2dmf8AyYaRpp3SB9MyjE4nzFltyZyNDZT56mhMQzoM53LmFb-3sRH51PwF4kOLqFJ-I68Gc2U8P1xnpGf119_XH2rbu9uvl9d3lZWNk2uGDTN0PIWTd8BM7VVXBg-DqoH0XSIylrOe8ZH1vWjko0d0XRokVkluRANPyMXh96nGH4t5VY9u2RxmozHsCTdta3sOIP2v2TLBRM1KFbI8xfJmrFOQiMKKA6gjSGliKN-im428Vkz0Ks4vdcHcXoVt26LuBL7eOxf-hmHf6GjqQJ8OgImFTVjNN669JerayZl8Vu4LwcOy4d_O4w6WYfe4uAi2qyH4F6-5A-PerlN</recordid><startdate>20091231</startdate><enddate>20091231</enddate><creator>Blandini, F.</creator><creator>Balestra, B.</creator><creator>Levandis, G.</creator><creator>Cervio, M.</creator><creator>Greco, R.</creator><creator>Tassorelli, C.</creator><creator>Colucci, M.</creator><creator>Faniglione, M.</creator><creator>Bazzini, E.</creator><creator>Nappi, G.</creator><creator>Clavenzani, P.</creator><creator>Vigneri, S.</creator><creator>De Giorgio, R.</creator><creator>Tonini, M.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20091231</creationdate><title>Functional and neurochemical changes of the gastrointestinal tract in a rodent model of Parkinson's disease</title><author>Blandini, F. ; Balestra, B. ; Levandis, G. ; Cervio, M. ; Greco, R. ; Tassorelli, C. ; Colucci, M. ; Faniglione, M. ; Bazzini, E. ; Nappi, G. ; Clavenzani, P. ; Vigneri, S. ; De Giorgio, R. ; Tonini, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c566t-1066d737eab801a2c934a3fd9b0468ee9cc33b13f18bf956cfea8ece1c9534463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Colon - innervation</topic><topic>Colon - physiopathology</topic><topic>Constipation</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Disease Models, Animal</topic><topic>Enteric Nervous System - metabolism</topic><topic>Enteric Nervous System - pathology</topic><topic>Enteric Nervous System - physiopathology</topic><topic>Enteric neurons</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastrointestinal Diseases - etiology</topic><topic>Gastrointestinal Diseases - metabolism</topic><topic>Gastrointestinal Diseases - physiopathology</topic><topic>Gastrointestinal Motility - physiology</topic><topic>Gut dysfunction</topic><topic>Ileum - innervation</topic><topic>Ileum - physiopathology</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Neuronal Plasticity - physiology</topic><topic>Neuroplasticity</topic><topic>Nitrergic Neurons - metabolism</topic><topic>Nitrergic Neurons - pathology</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Oxidopamine</topic><topic>Parkinson Disease - complications</topic><topic>Parkinsonian Disorders - complications</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blandini, F.</creatorcontrib><creatorcontrib>Balestra, B.</creatorcontrib><creatorcontrib>Levandis, G.</creatorcontrib><creatorcontrib>Cervio, M.</creatorcontrib><creatorcontrib>Greco, R.</creatorcontrib><creatorcontrib>Tassorelli, C.</creatorcontrib><creatorcontrib>Colucci, M.</creatorcontrib><creatorcontrib>Faniglione, M.</creatorcontrib><creatorcontrib>Bazzini, E.</creatorcontrib><creatorcontrib>Nappi, G.</creatorcontrib><creatorcontrib>Clavenzani, P.</creatorcontrib><creatorcontrib>Vigneri, S.</creatorcontrib><creatorcontrib>De Giorgio, R.</creatorcontrib><creatorcontrib>Tonini, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blandini, F.</au><au>Balestra, B.</au><au>Levandis, G.</au><au>Cervio, M.</au><au>Greco, R.</au><au>Tassorelli, C.</au><au>Colucci, M.</au><au>Faniglione, M.</au><au>Bazzini, E.</au><au>Nappi, G.</au><au>Clavenzani, P.</au><au>Vigneri, S.</au><au>De Giorgio, R.</au><au>Tonini, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional and neurochemical changes of the gastrointestinal tract in a rodent model of Parkinson's disease</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2009-12-31</date><risdate>2009</risdate><volume>467</volume><issue>3</issue><spage>203</spage><epage>207</epage><pages>203-207</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Patients with Parkinson's disease develop motor disturbances often accompanied by peripheral autonomic dysfunctions, including gastrointestinal disorders, such as dysphagia, gastric stasis and constipation. While the mechanisms subserving enteric autonomic dysfunctions are not clearly understood, they may involve the enteric dopaminergic and/or nitrergic systems. In the present study, we demonstrate that rats with unilateral 6-hydroxydopamine lesion of nigrostriatal dopaminergic neurons develop a marked inhibition of propulsive activity compared to sham-operated controls, as indicated by a 60% reduction of daily fecal output at the 4th week of observation. Immunohistochemical data revealed that 6-hydroxydopamine treatment did not affect the total number of HuC/D-positive myenteric neurons in both the proximal and distal segments of ileum and colon. Conversely, in the distal ileum and proximal colon the number of nitrergic neurons was significantly reduced. These results suggest that a disturbed distal gut transit, reminiscent of constipation in the clinical setting, may occur as a consequence of a reduced propulsive motility, likely due to an impairment of a nitric oxide-mediated descending inhibition during peristalsis.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19835930</pmid><doi>10.1016/j.neulet.2009.10.035</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neuroscience letters, 2009-12, Vol.467 (3), p.203-207 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Colon - innervation Colon - physiopathology Constipation Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Enteric Nervous System - metabolism Enteric Nervous System - pathology Enteric Nervous System - physiopathology Enteric neurons Fundamental and applied biological sciences. Psychology Gastrointestinal Diseases - etiology Gastrointestinal Diseases - metabolism Gastrointestinal Diseases - physiopathology Gastrointestinal Motility - physiology Gut dysfunction Ileum - innervation Ileum - physiopathology Immunohistochemistry Male Medical sciences Neurology Neuronal Plasticity - physiology Neuroplasticity Nitrergic Neurons - metabolism Nitrergic Neurons - pathology Nitric oxide Nitric Oxide - metabolism Oxidopamine Parkinson Disease - complications Parkinsonian Disorders - complications Rats Rats, Sprague-Dawley Vertebrates: nervous system and sense organs |
| title | Functional and neurochemical changes of the gastrointestinal tract in a rodent model of Parkinson's disease |
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