Evaluation of Krebs cycle enzymes in the brain of rats after chronic administration of antidepressants

Abstract Several works report brain impairment of metabolism as a mechanism underlying depression. Citrate synthase and succinate dehydrogenase are enzymes localized within cells in the mitochondrial matrix and are important steps of Krebs cycle. In addition, citrate synthase has been used as a quan...

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Veröffentlicht in:	Brain research bulletin 2010-05, Vol.82 (3), p.224-227
Hauptverfasser:	Scaini, Giselli, Santos, Patricia M, Benedet, Joana, Rochi, Natália, Gomes, Lara M, Borges, Lislaine S, Rezin, Gislaine T, Pezente, Daiana P, Quevedo, João, Streck, Emilio L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - administration & dosage Antidepressive Agents - pharmacology Brain Brain - anatomy & histology Brain - drug effects Brain - enzymology Citrate (si)-Synthase - metabolism Citrate synthase Citric Acid Cycle - drug effects Citric Acid Cycle - physiology Cyclohexanols - administration & dosage Cyclohexanols - pharmacology Male Neurology Nortriptiline Nortriptyline - administration & dosage Nortriptyline - pharmacology Paroxetine Paroxetine - administration & dosage Paroxetine - pharmacology Rats Rats, Wistar Succinate dehydrogenase Succinate Dehydrogenase - metabolism Venlafaxine Venlafaxine Hydrochloride
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