Chronic brain inflammation impairs two forms of long-term potentiation in the rat hippocampal CA1 area

Neuroinflammation plays an important role in the progression of Alzheimer's disease (AD) and is characterized by the presence of activated microglia. We investigated whether chronic neuroinflammation affects the induction of N-methyl- d-aspartate receptor (NMDAR)-dependent long-term potentiatio...

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Veröffentlicht in:	Neuroscience letters 2009-05, Vol.456 (1), p.20-24
Hauptverfasser:	Min, Sun Seek, Quan, Hui Yan, Ma, Jinhua, Han, Jung-Soo, Jeon, Byeong Hwa, Seol, Geun Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Biological and medical sciences Calcium Channels - drug effects Calcium Channels - metabolism Chronic Disease Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - physiopathology Inflammation - chemically induced Inflammation - physiopathology Lipopolysaccharides - toxicity Long-term potentiation Long-Term Potentiation - physiology Male Maze Learning - drug effects Memory Neuroinflammation NMDA-dependent LTP Rats Rats, Inbred F344 Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - metabolism VDCC-dependent LTP Vertebrates: nervous system and sense organs
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