Preliminary evidence of association between EFHC2, a gene implicated in fear recognition, and harm avoidance
Genetic variation at the EF-hand domain containing 2 gene ( EFHC2) locus has been associated with fear recognition in Turner syndrome. The aim of this study was to examine whether EFHC2 variants are associated with non-syndromic anxiety-related traits [harm avoidance (HA) and behavioral inhibition (...
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| Veröffentlicht in: | Neuroscience letters 2009-03, Vol.452 (1), p.84-86 |
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| creator | Blaya, Carolina Moorjani, Priya Salum, Giovanni Abrahão Gonçalves, Leonardo Weiss, Lauren A. Leistner-Segal, Sandra Manfro, Gisele G. Smoller, Jordan W. |
| description | Genetic variation at the EF-hand domain containing 2 gene (
EFHC2) locus has been associated with fear recognition in Turner syndrome. The aim of this study was to examine whether
EFHC2 variants are associated with non-syndromic anxiety-related traits [harm avoidance (HA) and behavioral inhibition (BI)] and with panic disorder (PD). Our sample comprised 127 PD patients and 132 controls without psychiatric disorder. We genotyped nine SNPs within the
EFHC2 locus and used PLINK to perform association analyses. An intronic SNP (rs1562875) was associated with HA (permuted
p
=
0.031) accounting alone for over 3% of variance in this trait. This same SNP was nominally, but not empirically, associated with BI (
r
2
=
0.022; nominal
p
=
0.022) and PD (OR
=
2.64; nominal
p
=
0.009). The same association was found in a subsample of only females. In sum, we observed evidence of association between a variant in
EFHC2, a gene previously associated with the processing of fear and social threat, and HA. Larger studies are warranted to confirm this association. |
| doi_str_mv | 10.1016/j.neulet.2009.01.036 |
| format | Article |
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EFHC2) locus has been associated with fear recognition in Turner syndrome. The aim of this study was to examine whether
EFHC2 variants are associated with non-syndromic anxiety-related traits [harm avoidance (HA) and behavioral inhibition (BI)] and with panic disorder (PD). Our sample comprised 127 PD patients and 132 controls without psychiatric disorder. We genotyped nine SNPs within the
EFHC2 locus and used PLINK to perform association analyses. An intronic SNP (rs1562875) was associated with HA (permuted
p
=
0.031) accounting alone for over 3% of variance in this trait. This same SNP was nominally, but not empirically, associated with BI (
r
2
=
0.022; nominal
p
=
0.022) and PD (OR
=
2.64; nominal
p
=
0.009). The same association was found in a subsample of only females. In sum, we observed evidence of association between a variant in
EFHC2, a gene previously associated with the processing of fear and social threat, and HA. Larger studies are warranted to confirm this association.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2009.01.036</identifier><identifier>PMID: 19429002</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Anxiety ; Biological and medical sciences ; Calcium-Binding Proteins - genetics ; EFHC2 ; Fear - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Harm Reduction - physiology ; Harm-avoidance ; Humans ; Inhibition, Psychological ; Male ; Middle Aged ; Panic ; Polymorphism, Single Nucleotide - genetics ; Recognition, Psychology - physiology ; Somatoform Disorders - genetics ; Somatoform Disorders - physiopathology ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2009-03, Vol.452 (1), p.84-86</ispartof><rights>2009 Elsevier Ireland Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-4977a41730407473a2c018e8ffc1c4bc8635dd403df2e716e6ff9d59135a980f3</citedby><cites>FETCH-LOGICAL-c488t-4977a41730407473a2c018e8ffc1c4bc8635dd403df2e716e6ff9d59135a980f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2009.01.036$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21278517$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19429002$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blaya, Carolina</creatorcontrib><creatorcontrib>Moorjani, Priya</creatorcontrib><creatorcontrib>Salum, Giovanni Abrahão</creatorcontrib><creatorcontrib>Gonçalves, Leonardo</creatorcontrib><creatorcontrib>Weiss, Lauren A.</creatorcontrib><creatorcontrib>Leistner-Segal, Sandra</creatorcontrib><creatorcontrib>Manfro, Gisele G.</creatorcontrib><creatorcontrib>Smoller, Jordan W.</creatorcontrib><title>Preliminary evidence of association between EFHC2, a gene implicated in fear recognition, and harm avoidance</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Genetic variation at the EF-hand domain containing 2 gene (
EFHC2) locus has been associated with fear recognition in Turner syndrome. The aim of this study was to examine whether
EFHC2 variants are associated with non-syndromic anxiety-related traits [harm avoidance (HA) and behavioral inhibition (BI)] and with panic disorder (PD). Our sample comprised 127 PD patients and 132 controls without psychiatric disorder. We genotyped nine SNPs within the
EFHC2 locus and used PLINK to perform association analyses. An intronic SNP (rs1562875) was associated with HA (permuted
p
=
0.031) accounting alone for over 3% of variance in this trait. This same SNP was nominally, but not empirically, associated with BI (
r
2
=
0.022; nominal
p
=
0.022) and PD (OR
=
2.64; nominal
p
=
0.009). The same association was found in a subsample of only females. In sum, we observed evidence of association between a variant in
EFHC2, a gene previously associated with the processing of fear and social threat, and HA. Larger studies are warranted to confirm this association.</description><subject>Adult</subject><subject>Anxiety</subject><subject>Biological and medical sciences</subject><subject>Calcium-Binding Proteins - genetics</subject><subject>EFHC2</subject><subject>Fear - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Harm Reduction - physiology</subject><subject>Harm-avoidance</subject><subject>Humans</subject><subject>Inhibition, Psychological</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Panic</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Recognition, Psychology - physiology</subject><subject>Somatoform Disorders - genetics</subject><subject>Somatoform Disorders - physiopathology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcGO0zAURS0EYkrhDxDyBtiQ8Ow4sb0ZCVUzDNJIsIC15drPg6vEKXZaxN_jqhXsZvU251493UPIawYtAzZ83LUJDyMuLQfQLbAWuuEJWTEleSO15E_JCjoQTacFXJEXpewAoGe9eE6umBZcA_AVGb9lHOMUk81_KB6jx-SQzoHaUmYX7RLnRLe4_EZM9Ob2bsM_UEsfMCGN036Mzi7oaUw0oM00o5sfUjyFKpY8_WnzRO1xjt7W3pfkWbBjwVeXuyY_bm--b-6a-6-fv2w-3TdOKLU0QktpBZP1e5BCdpY7YApVCI45sXVq6HrvBXQ-cJRswCEE7XvNut5qBaFbk_fn3n2efx2wLGaKxeE42oTzoRglZS8HrfpKvnuUHCSvQw0nUJxBl-dSMgazz3GqoxkG5uTD7MzZhzn5MMBM9VFjby79h-2E_n_oIqACby-ALc6OIdedYvnHccal6usUa3J95rDudoyYTXHx5MrHOvpi_Bwf_-QvuyKqKw</recordid><startdate>20090306</startdate><enddate>20090306</enddate><creator>Blaya, Carolina</creator><creator>Moorjani, Priya</creator><creator>Salum, Giovanni Abrahão</creator><creator>Gonçalves, Leonardo</creator><creator>Weiss, Lauren A.</creator><creator>Leistner-Segal, Sandra</creator><creator>Manfro, Gisele G.</creator><creator>Smoller, Jordan W.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20090306</creationdate><title>Preliminary evidence of association between EFHC2, a gene implicated in fear recognition, and harm avoidance</title><author>Blaya, Carolina ; Moorjani, Priya ; Salum, Giovanni Abrahão ; Gonçalves, Leonardo ; Weiss, Lauren A. ; Leistner-Segal, Sandra ; Manfro, Gisele G. ; Smoller, Jordan W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-4977a41730407473a2c018e8ffc1c4bc8635dd403df2e716e6ff9d59135a980f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Anxiety</topic><topic>Biological and medical sciences</topic><topic>Calcium-Binding Proteins - genetics</topic><topic>EFHC2</topic><topic>Fear - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Harm Reduction - physiology</topic><topic>Harm-avoidance</topic><topic>Humans</topic><topic>Inhibition, Psychological</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Panic</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Recognition, Psychology - physiology</topic><topic>Somatoform Disorders - genetics</topic><topic>Somatoform Disorders - physiopathology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blaya, Carolina</creatorcontrib><creatorcontrib>Moorjani, Priya</creatorcontrib><creatorcontrib>Salum, Giovanni Abrahão</creatorcontrib><creatorcontrib>Gonçalves, Leonardo</creatorcontrib><creatorcontrib>Weiss, Lauren A.</creatorcontrib><creatorcontrib>Leistner-Segal, Sandra</creatorcontrib><creatorcontrib>Manfro, Gisele G.</creatorcontrib><creatorcontrib>Smoller, Jordan W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blaya, Carolina</au><au>Moorjani, Priya</au><au>Salum, Giovanni Abrahão</au><au>Gonçalves, Leonardo</au><au>Weiss, Lauren A.</au><au>Leistner-Segal, Sandra</au><au>Manfro, Gisele G.</au><au>Smoller, Jordan W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preliminary evidence of association between EFHC2, a gene implicated in fear recognition, and harm avoidance</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2009-03-06</date><risdate>2009</risdate><volume>452</volume><issue>1</issue><spage>84</spage><epage>86</epage><pages>84-86</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Genetic variation at the EF-hand domain containing 2 gene (
EFHC2) locus has been associated with fear recognition in Turner syndrome. The aim of this study was to examine whether
EFHC2 variants are associated with non-syndromic anxiety-related traits [harm avoidance (HA) and behavioral inhibition (BI)] and with panic disorder (PD). Our sample comprised 127 PD patients and 132 controls without psychiatric disorder. We genotyped nine SNPs within the
EFHC2 locus and used PLINK to perform association analyses. An intronic SNP (rs1562875) was associated with HA (permuted
p
=
0.031) accounting alone for over 3% of variance in this trait. This same SNP was nominally, but not empirically, associated with BI (
r
2
=
0.022; nominal
p
=
0.022) and PD (OR
=
2.64; nominal
p
=
0.009). The same association was found in a subsample of only females. In sum, we observed evidence of association between a variant in
EFHC2, a gene previously associated with the processing of fear and social threat, and HA. Larger studies are warranted to confirm this association.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19429002</pmid><doi>10.1016/j.neulet.2009.01.036</doi><tpages>3</tpages></addata></record> |
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| ispartof | Neuroscience letters, 2009-03, Vol.452 (1), p.84-86 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Anxiety Biological and medical sciences Calcium-Binding Proteins - genetics EFHC2 Fear - physiology Female Fundamental and applied biological sciences. Psychology Gene Frequency Genetic Predisposition to Disease Genotype Harm Reduction - physiology Harm-avoidance Humans Inhibition, Psychological Male Middle Aged Panic Polymorphism, Single Nucleotide - genetics Recognition, Psychology - physiology Somatoform Disorders - genetics Somatoform Disorders - physiopathology Vertebrates: nervous system and sense organs |
| title | Preliminary evidence of association between EFHC2, a gene implicated in fear recognition, and harm avoidance |
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