Medicinal plants and antioxidants: What do we learn from cell culture and Caenorhabditis elegans studies?
Traditional medicinal plants have a long history of therapeutic use. The beneficial health effects of medicinal plants rich in polyphenols are often attributed to their potent antioxidant activities, as established in vitro, since diets rich in polyphenols are epidemiologically associated with a dec...
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Veröffentlicht in: | Biochemical and biophysical research communications 2010-03, Vol.394 (1), p.1-5 |
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description | Traditional medicinal plants have a long history of therapeutic use. The beneficial health effects of medicinal plants rich in polyphenols are often attributed to their potent antioxidant activities, as established in vitro, since diets rich in polyphenols are epidemiologically associated with a decreased incidence of age-related diseases in humans. However, medicinal plants may also exert pro-oxidant effects that up-regulate endogenous protective enzymes. Care is needed when studying the biological effects of medicinal plants in cell culture because some polyphenols oxidize readily in culture media. This review summarizes the data we have obtained from in vitro and in vivo (Caenorhabditis elegans) studies examining the diverse effects of traditional medicinal plants and their modes of action. |
doi_str_mv | 10.1016/j.bbrc.2010.02.137 |
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The beneficial health effects of medicinal plants rich in polyphenols are often attributed to their potent antioxidant activities, as established in vitro, since diets rich in polyphenols are epidemiologically associated with a decreased incidence of age-related diseases in humans. However, medicinal plants may also exert pro-oxidant effects that up-regulate endogenous protective enzymes. Care is needed when studying the biological effects of medicinal plants in cell culture because some polyphenols oxidize readily in culture media. 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This review summarizes the data we have obtained from in vitro and in vivo (Caenorhabditis elegans) studies examining the diverse effects of traditional medicinal plants and their modes of action.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>Caenorhabditis elegans</subject><subject>Caenorhabditis elegans - cytology</subject><subject>Caenorhabditis elegans - drug effects</subject><subject>Cell culture</subject><subject>Cell Culture Techniques</subject><subject>Drug Evaluation, Preclinical</subject><subject>Oxidative Stress</subject><subject>Plants, Medicinal - chemistry</subject><subject>Polyphenols</subject><subject>Traditional medicinal plants</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1q3DAURkVpaCaTvEAXQbuuPLmSbMsqhVKG5gdSsmlJdkKWrhMNHnsqyU3z9pU7aZbpQggu5_sk7iHkPYMVA1afbVZtG-yKQx4AXzEh35AFAwUFZ1C-JQsAqAuu2N0hOYpxA8BYWat35DBHmgZkuSD-Gzpv_WB6uuvNkCI1g8sn-fG3d_PgI719MIm6kT4i7dGEgXZh3FKLfU_t1Kcp4N_Q2uAwhgfTOp98pNjjvRkijWlyHuPnY3LQmT7iyfO9JD_Ov35fXxbXNxdX6y_XhS0rkYquVqUSlW2lBCeNAwFWSYW1NFirunUlbztrZdd0jeXCWOQdE7YBJfPLhokl-bDv3YXx54Qx6a2P82fNgOMUdSNlJSuo1H9JKUQjlJQyk3xP2jDGGLDTu-C3JjxpBnp2oTd6dqFnFxq4zi5y6PS5fmq36F4i_5afgU97APM6fnkMOlqPg81GAtqk3ehf6_8Dqhab0g</recordid><startdate>20100326</startdate><enddate>20100326</enddate><creator>Tang, Soon Yew</creator><creator>Halliwell, Barry</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20100326</creationdate><title>Medicinal plants and antioxidants: What do we learn from cell culture and Caenorhabditis elegans studies?</title><author>Tang, Soon Yew ; Halliwell, Barry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-f694935cb770d7ad030c979e67ae696bd42bfcc7f8f8c23ace2f13c8097abda13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - pharmacology</topic><topic>Caenorhabditis elegans</topic><topic>Caenorhabditis elegans - cytology</topic><topic>Caenorhabditis elegans - drug effects</topic><topic>Cell culture</topic><topic>Cell Culture Techniques</topic><topic>Drug Evaluation, Preclinical</topic><topic>Oxidative Stress</topic><topic>Plants, Medicinal - chemistry</topic><topic>Polyphenols</topic><topic>Traditional medicinal plants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, Soon Yew</creatorcontrib><creatorcontrib>Halliwell, Barry</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Soon Yew</au><au>Halliwell, Barry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Medicinal plants and antioxidants: What do we learn from cell culture and Caenorhabditis elegans studies?</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2010-03-26</date><risdate>2010</risdate><volume>394</volume><issue>1</issue><spage>1</spage><epage>5</epage><pages>1-5</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Traditional medicinal plants have a long history of therapeutic use. 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subjects | Animals Antioxidants Antioxidants - chemistry Antioxidants - pharmacology Caenorhabditis elegans Caenorhabditis elegans - cytology Caenorhabditis elegans - drug effects Cell culture Cell Culture Techniques Drug Evaluation, Preclinical Oxidative Stress Plants, Medicinal - chemistry Polyphenols Traditional medicinal plants |
title | Medicinal plants and antioxidants: What do we learn from cell culture and Caenorhabditis elegans studies? |
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