Targeting of the prostacyclin specific IP1 receptor in lungs with molecular conjugates comprising prostaglandin I2 analogues

Abstract Molecular conjugates comprising targeting ligands hold great promise for site-specific gene delivery to distant tumors and individual organs including the lung. Here we show that prostaglandin I2 analogues can be used to improve gene transfer efficiency of polyethylenimine (PEI) gene vector...

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Veröffentlicht in:	Biomaterials 2010-04, Vol.31 (10), p.2903-2911
Hauptverfasser:	Geiger, Johannes, Aneja, Manish K, Hasenpusch, Günther, Yüksekdag, Gülnihal, Kummerlöwe, Grit, Luy, Burkhard, Romer, Tina, Rothbauer, Ulrich, Rudolph, Carsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Blotting, Western Cattle Cell Line Dentistry Epithelial Cells - drug effects Epithelial Cells - metabolism Epoprostenol - analogs & derivatives Epoprostenol - pharmacology Female Fluorescein - metabolism Genetic Vectors - genetics Humans Iloprost - metabolism Iloprost - pharmacology Ligands Lung - metabolism Mice Mice, Inbred BALB C Organ Specificity - drug effects Polyethyleneimine - metabolism Receptors, Epoprostenol - metabolism Reproducibility of Results Serum Albumin, Bovine - metabolism Transfection
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