Studies on the structural stability of rabbit prion probed by molecular dynamics simulations of its wild-type and mutants

Prion diseases are invariably fatal and highly infectious neurodegenerative diseases that affect humans and animals. Rabbits are the only mammalian species reported to be resistant to infection from prion diseases isolated from other species ( Vorberg et al., 2003). Fortunately, the NMR structure of...

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Veröffentlicht in:	Journal of theoretical biology 2010-05, Vol.264 (1), p.119-122
1. Verfasser:	Zhang, Jiapu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Hydrogen Bonding Hydrogen-Ion Concentration Immunity Molecular dynamics Molecular Dynamics Simulation Nuclear Magnetic Resonance, Biomolecular Prion diseases Prions - chemistry Protein Conformation Protein Stability Protein Structure, Secondary Rabbit prion Rabbits
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