Efficient prediction methods for selecting effective siRNA sequences

Abstract Although short interfering RNA (siRNA) has been widely used for studying gene functions in mammalian cells, its gene silencing efficacy varies markedly and there are only a few consistencies among the recently reported design rules/guidelines for selecting siRNA sequences effective for mamm...

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Veröffentlicht in:	Computers in biology and medicine 2010-02, Vol.40 (2), p.149-158
1. Verfasser:	Takasaki, Shigeru
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Artificial Intelligence Base Sequence Candidates Computational Biology - methods Computer-Aided Design Data mining Databases, Nucleic Acid Decision Trees Design Estimation of gene silencing Gene Silencing Humans Internal Medicine Mathematical programming Methods Neural Networks (Computer) Other Probability RBF network Ribonucleic acid RNA RNA Interference RNA, Small Interfering - genetics RNA, Small Interfering - metabolism ROC Curve siRNA design Studies
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