Co-delivery of siRNA and paclitaxel into cancer cells by biodegradable cationic micelles based on PDMAEMA–PCL–PDMAEMA triblock copolymers

Abstract Biodegradable cationic micelles were prepared from PDMAEMA–PCL–PDMAEMA triblock copolymers and applied for the delivery of siRNA and paclitaxel into cancer cells. PDMAEMA–PCL–PDMAEMA copolymers were readily obtained by reversible addition-fragmentation chain transfer (RAFT) polymerization o...

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Veröffentlicht in:	Biomaterials 2010-03, Vol.31 (8), p.2408-2416
Hauptverfasser:	Zhu, Caihong, Jung, Sooyeon, Luo, Sibin, Meng, Fenghua, Zhu, Xiulin, Park, Tae Gwan, Zhong, Zhiyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Antineoplastic Agents, Phytogenic - metabolism Antineoplastic Agents, Phytogenic - pharmacology Cations - chemistry Cell Line, Tumor - drug effects Dentistry Drug Carriers - chemistry Drug delivery Drug Delivery Systems Gene delivery Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humans Materials Testing Methacrylates - chemistry Micelles Molecular Structure Molecular Weight Nylons - chemistry Paclitaxel Paclitaxel - metabolism Paclitaxel - pharmacology Particle Size RNA, Small Interfering - genetics RNA, Small Interfering - metabolism siRNA Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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