HIV-1 non-B subtypes: High transmitted NNRTI-resistance in Spain and impaired genotypic resistance interpretation due to variability

Genotypic resistance algorithms interpret drug-resistance mutations, but are mainly developed for HIV-1 subtype B, meanwhile non-B subtypes cause 90% of worldwide infections. They include clade-specific amino acid at drug-resistance positions different than subtype B. This study explores: (i) the va...

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Veröffentlicht in:	Antiviral research 2010-02, Vol.85 (2), p.409-417
Hauptverfasser:	Yebra, G., de Mulder, M., del Romero, J., Rodríguez, C., Holguín, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Drug Resistance, Viral Drug-resistance mutations Genotype Genotypic resistance algorithms HIV Infections - transmission HIV Infections - virology HIV-1 - classification HIV-1 - drug effects HIV-1 - genetics HIV-1 - isolation & purification HIV-1 subtypes Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Medical sciences Molecular Sequence Data Pharmacology. Drug treatments Phylogeny Polymorphism, Genetic Prevalence Sequence Analysis, DNA Spain Subtyping tools Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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