SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

The sirtuin gene family ( SIRT) is hypothesized to regulate the aging process and play a role in cellular repair. This work demonstrates that SIRT3 −/− mouse embryonic fibroblasts (MEFs) exhibit abnormal mitochondrial physiology as well as increases in stress-induced superoxide levels and genomic in...

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Veröffentlicht in:	Cancer cell 2010-01, Vol.17 (1), p.41-52
Hauptverfasser:	Kim, Hyun-Seok, Patel, Krish, Muldoon-Jacobs, Kristi, Bisht, Kheem S., Aykin-Burns, Nukhet, Pennington, J. Daniel, van der Meer, Riet, Nguyen, Phuongmai, Savage, Jason, Owens, Kjerstin M., Vassilopoulos, Athanassios, Ozden, Ozkan, Park, Seong-Hoon, Singh, Keshav K., Abdulkadir, Sarki A., Spitz, Douglas R., Deng, Chu-Xia, Gius, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell Transformation, Neoplastic - genetics CELLCYCLE Female Fibroblasts - metabolism Genes, Tumor Suppressor Humans Immunohistochemistry Mice Mice, Knockout Mitochondria - metabolism Oxidative Stress - physiology PROTEINS Sirtuin 3 - genetics Sirtuin 3 - metabolism Stress, Physiological - physiology Superoxides - metabolism
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