Knockdown of Cav2.1 calcium channels is sufficient to induce neurological disorders observed in natural occurring Cacna1a mutants in mice

The CACNA1A gene encodes the poreforming, voltage-sensitive subunit of the voltage-dependent Ca(v)2.1 calcium channel. Mutations in this gene have been linked to several human disorders, including familial hemiplegic migraine type 1, episodic ataxia type 2, and spinocerebellar ataxia type 6. In mice...

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Veröffentlicht in:	Biochemical and biophysical research communications 2009-12, Vol.390 (3), p.1029-1033
Hauptverfasser:	Saito, Hiromitsu, Okada, Motohiro, Miki, Takafumi, Wakamori, Minoru, Futatsugi, Akira, Mori, Yasuo, Mikoshiba, Katsuhiko, Suzuki, Noboru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Channels, N-Type - genetics Calcium Channels, P-Type - genetics Calcium Channels, Q-Type - genetics Cerebellar Ataxia - genetics Cerebellar Ataxia - pathology Cerebellar Ataxia - physiopathology Disease Models, Animal Electrophysiological Phenomena Gene Knockdown Techniques Humans Male Mice Mice, Mutant Strains
Online-Zugang:	Volltext
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