Immunoglobulin class switch recombination deficiencies

Abstract Maturation of the secondary antibody repertoire is generated by means of class switch recombination and somatic hypermutation. The molecular mechanisms underlying these important processes have long remained obscure. Inherited defects in class switch recombination variably associated to def...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2010-05, Vol.135 (2), p.193-203
Hauptverfasser:	Kracker, S, Gardes, P, Mazerolles, F, Durandy, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation-induced cytidine deaminase Allergy and Immunology Animals CD40 CD40 ligand Class switch recombination Humans Immunoglobulin Class Switching Immunologic Deficiency Syndromes - genetics Immunologic Deficiency Syndromes - immunology Inherited immunodeficiencies NF-kB essential modulator Post-meiotic segregation 2 Somatic Hypermutation, Immunoglobulin Somatic hypermutations Uracil- N-glycosylase
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