CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9

We previously reported the strong immunostimulatory effects of a CpG oligodeoxynucleotide (ODN), designated MsST, from the lacZ gene of Streptococcus (S.) thermophilus ATCC19258. Here we show that 24h of stimulation with MsST in mouse splenocytes and peritoneal macrophages strongly induces expressio...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-03, Vol.394 (1), p.81-86
Hauptverfasser:	Shimosato, Takeshi, Fujimoto, Megumi, Tohno, Masanori, Sato, Takashi, Tateo, Mariko, Otani, Hajime, Kitazawa, Haruki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Galactosidase - genetics CpG Islands - immunology CpG-ODN IL-1 superfamily IL-33 Immunologic Factors - pharmacology Immunomodulation Interleukin-33 Interleukins - biosynthesis Lac Operon - immunology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Male Mice Mice, Inbred C57BL Oligodeoxyribonucleotides - immunology Oligodeoxyribonucleotides - pharmacology Streptococcus Streptococcus thermophilus Streptococcus thermophilus - genetics Streptococcus thermophilus - immunology TLR9 Toll-Like Receptor 9 - metabolism Up-Regulation
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