A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting: In vitro evaluation
In this study, a novel pH-responsive nanogel composed of glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups (denoted as GCS- g-DEAP hereafter) was fabricated. The GCS- g-DEAP was designed to have a self-assembled arrangement consisting of hydrophilic block (GCS) and hyd...
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| Veröffentlicht in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2010-06, Vol.78 (1), p.120-126 |
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| container_title | Colloids and surfaces, B, Biointerfaces |
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| creator | Oh, Nam Muk Oh, Kyung Taek Baik, Hye Jung Lee, Bo Reum Lee, A. Hyeong Youn, Yu Seok Lee, Eun Seong |
| description | In this study, a novel pH-responsive nanogel composed of glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups (denoted as GCS-
g-DEAP hereafter) was fabricated. The GCS-
g-DEAP was designed to have a self-assembled arrangement consisting of hydrophilic block (GCS) and hydrophobic block (DEAP) at physiological pH. As the pH decreased to tumor extracellular pH (pH
e), the nanogel was destabilized due to the protonation of DEAP. The pH-responsive property of the nanogel at tumor extracellular pH (pH
e) was characterized in drug-release kinetic studies. The release of doxorubicin (DOX) from DOX-loaded nanogels was significantly accelerated at lower pH values, which allowed for increased DOX uptake by non-small lung carcinoma A546 cells under a slightly acidic pH condition, as in tumor pH
e. |
| doi_str_mv | 10.1016/j.colsurfb.2010.02.023 |
| format | Article |
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g-DEAP hereafter) was fabricated. The GCS-
g-DEAP was designed to have a self-assembled arrangement consisting of hydrophilic block (GCS) and hydrophobic block (DEAP) at physiological pH. As the pH decreased to tumor extracellular pH (pH
e), the nanogel was destabilized due to the protonation of DEAP. The pH-responsive property of the nanogel at tumor extracellular pH (pH
e) was characterized in drug-release kinetic studies. The release of doxorubicin (DOX) from DOX-loaded nanogels was significantly accelerated at lower pH values, which allowed for increased DOX uptake by non-small lung carcinoma A546 cells under a slightly acidic pH condition, as in tumor pH
e.</description><identifier>ISSN: 0927-7765</identifier><identifier>EISSN: 1873-4367</identifier><identifier>DOI: 10.1016/j.colsurfb.2010.02.023</identifier><identifier>PMID: 20299192</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>3-Diethylaminopropyl ; Amines - chemistry ; Cell Line, Tumor ; Chitosan - analogs & derivatives ; Chitosan - chemistry ; Doxorubicin - pharmacology ; Drug Delivery Systems - methods ; Glycol chitosan ; Humans ; Hydrogen-Ion Concentration - drug effects ; Microscopy, Electron, Scanning ; Neoplasms - metabolism ; Particle Size ; pH-responsive nanogel ; Polyethylene Glycols - chemistry ; Polyethyleneimine - chemistry ; Solutions ; Tumor extracellular pH</subject><ispartof>Colloids and surfaces, B, Biointerfaces, 2010-06, Vol.78 (1), p.120-126</ispartof><rights>2010 Elsevier B.V.</rights><rights>Copyright 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-739db9f61d6ba75a299388986c4b000593984b0ec4764187f3270454e747999f3</citedby><cites>FETCH-LOGICAL-c399t-739db9f61d6ba75a299388986c4b000593984b0ec4764187f3270454e747999f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.colsurfb.2010.02.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20299192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oh, Nam Muk</creatorcontrib><creatorcontrib>Oh, Kyung Taek</creatorcontrib><creatorcontrib>Baik, Hye Jung</creatorcontrib><creatorcontrib>Lee, Bo Reum</creatorcontrib><creatorcontrib>Lee, A. Hyeong</creatorcontrib><creatorcontrib>Youn, Yu Seok</creatorcontrib><creatorcontrib>Lee, Eun Seong</creatorcontrib><title>A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting: In vitro evaluation</title><title>Colloids and surfaces, B, Biointerfaces</title><addtitle>Colloids Surf B Biointerfaces</addtitle><description>In this study, a novel pH-responsive nanogel composed of glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups (denoted as GCS-
g-DEAP hereafter) was fabricated. The GCS-
g-DEAP was designed to have a self-assembled arrangement consisting of hydrophilic block (GCS) and hydrophobic block (DEAP) at physiological pH. As the pH decreased to tumor extracellular pH (pH
e), the nanogel was destabilized due to the protonation of DEAP. The pH-responsive property of the nanogel at tumor extracellular pH (pH
e) was characterized in drug-release kinetic studies. The release of doxorubicin (DOX) from DOX-loaded nanogels was significantly accelerated at lower pH values, which allowed for increased DOX uptake by non-small lung carcinoma A546 cells under a slightly acidic pH condition, as in tumor pH
e.</description><subject>3-Diethylaminopropyl</subject><subject>Amines - chemistry</subject><subject>Cell Line, Tumor</subject><subject>Chitosan - analogs & derivatives</subject><subject>Chitosan - chemistry</subject><subject>Doxorubicin - pharmacology</subject><subject>Drug Delivery Systems - methods</subject><subject>Glycol chitosan</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration - drug effects</subject><subject>Microscopy, Electron, Scanning</subject><subject>Neoplasms - metabolism</subject><subject>Particle Size</subject><subject>pH-responsive nanogel</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyethyleneimine - chemistry</subject><subject>Solutions</subject><subject>Tumor extracellular pH</subject><issn>0927-7765</issn><issn>1873-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u3CAUhVHVqJkmeYWIXVee8mOD6apR1DaRInXTrBHG1w4jDFPAo06fvkSTdBvpChD6zr0cDkLXlGwpoeLzbmujz2uahi0j9ZKwWvwd2tBe8qblQr5HG6KYbKQU3Tn6mPOOEMJaKj-gc0aYUlSxDfpzgzP4qYlpNsH9hRHzZnRQno7eLC7EfYr7o28GMMmFGc_-WOdi--RKzCbgYEKcweMpJlzWpa7GutFZvL_DxaQZSlV9wfcBH1xJEcPB-NUUF8MlOpuMz3D1sl-gx-_fft3eNQ8_f9zf3jw0litVGsnVOKhJ0FEMRnamvpv3veqFbYfqp1Nc9fUEtpWird4nziRpuxZkK5VSE79An059q5PfK-SiF5cteG8CxDXrXsquKqh6k5Scd4JXtpLiRNoUc04w6X1yi0lHTYl-jkfv9Gs8-jkeTVgtXoXXLyPWYYHxv-w1jwp8PQFQv-TgIOlsHQQLo0tgix6je2vGPwp4pPA</recordid><startdate>20100615</startdate><enddate>20100615</enddate><creator>Oh, Nam Muk</creator><creator>Oh, Kyung Taek</creator><creator>Baik, Hye Jung</creator><creator>Lee, Bo Reum</creator><creator>Lee, A. 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Hyeong ; Youn, Yu Seok ; Lee, Eun Seong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-739db9f61d6ba75a299388986c4b000593984b0ec4764187f3270454e747999f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>3-Diethylaminopropyl</topic><topic>Amines - chemistry</topic><topic>Cell Line, Tumor</topic><topic>Chitosan - analogs & derivatives</topic><topic>Chitosan - chemistry</topic><topic>Doxorubicin - pharmacology</topic><topic>Drug Delivery Systems - methods</topic><topic>Glycol chitosan</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration - drug effects</topic><topic>Microscopy, Electron, Scanning</topic><topic>Neoplasms - metabolism</topic><topic>Particle Size</topic><topic>pH-responsive nanogel</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polyethyleneimine - chemistry</topic><topic>Solutions</topic><topic>Tumor extracellular pH</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oh, Nam Muk</creatorcontrib><creatorcontrib>Oh, Kyung Taek</creatorcontrib><creatorcontrib>Baik, Hye Jung</creatorcontrib><creatorcontrib>Lee, Bo Reum</creatorcontrib><creatorcontrib>Lee, A. 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g-DEAP hereafter) was fabricated. The GCS-
g-DEAP was designed to have a self-assembled arrangement consisting of hydrophilic block (GCS) and hydrophobic block (DEAP) at physiological pH. As the pH decreased to tumor extracellular pH (pH
e), the nanogel was destabilized due to the protonation of DEAP. The pH-responsive property of the nanogel at tumor extracellular pH (pH
e) was characterized in drug-release kinetic studies. The release of doxorubicin (DOX) from DOX-loaded nanogels was significantly accelerated at lower pH values, which allowed for increased DOX uptake by non-small lung carcinoma A546 cells under a slightly acidic pH condition, as in tumor pH
e.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>20299192</pmid><doi>10.1016/j.colsurfb.2010.02.023</doi><tpages>7</tpages></addata></record> |
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| ispartof | Colloids and surfaces, B, Biointerfaces, 2010-06, Vol.78 (1), p.120-126 |
| issn | 0927-7765 1873-4367 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | 3-Diethylaminopropyl Amines - chemistry Cell Line, Tumor Chitosan - analogs & derivatives Chitosan - chemistry Doxorubicin - pharmacology Drug Delivery Systems - methods Glycol chitosan Humans Hydrogen-Ion Concentration - drug effects Microscopy, Electron, Scanning Neoplasms - metabolism Particle Size pH-responsive nanogel Polyethylene Glycols - chemistry Polyethyleneimine - chemistry Solutions Tumor extracellular pH |
| title | A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting: In vitro evaluation |
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