Use of hydrophobins in formulation of water insoluble drugs for oral administration

The poor water solubility of many drugs requires a specific formulation to achieve a sufficient bioavailability after oral administration. Suspensions of small drug particles can be used to improve the bioavailability. We here show that the fungal hydrophobin SC3 can be used to make suspensions of w...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2010-02, Vol.75 (2), p.526-531
Hauptverfasser:	Haas Jimoh Akanbi, Marijke, Post, Eduard, Meter-Arkema, Anita, Rink, Rick, Robillard, George T., Wang, Xiaoqin, Wösten, Han A.B., Scholtmeijer, Karin
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Bioavailability Biological Availability Cyclosporine Cyclosporine - blood Drug Compounding Drug delivery Hydrophobic and Hydrophilic Interactions Hydrophobin Male Nifedipine Nifedipine - administration & dosage Particle Size Pharmaceutical Preparations - administration & dosage Rats Rats, Wistar Self-assembly Solubility Solutions Water - chemistry
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