The pH-dependent association with cancer cells of tunable functionalized lipid vesicles with encapsulated doxorubicin for high cell-kill selectivity

Abstract To enable selective cell-kill, we designed functionalized lipid vesicles with pH-triggered heterogeneous membranes and encapsulated doxorubicin that exhibit tunable surface topography. These vesicles “hide” (mask) the targeting ligands from their surface during circulation in the blood, and...

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Veröffentlicht in:	Biomaterials 2010-05, Vol.31 (15), p.4409-4416
Hauptverfasser:	Karve, Shrirang, Bandekar, Amey, Ali, Md. R, Sofou, Stavroula
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - pharmacology Calorimetry, Differential Scanning Cell Line, Tumor - drug effects Chemotherapy Dentistry Doxorubicin - administration & dosage Doxorubicin - chemistry Doxorubicin - pharmacology Drug Delivery Systems - methods Drug Screening Assays, Antitumor Humans Hydrogen-Ion Concentration Lipids - chemistry Liposomes Materials Testing Models, Molecular Targeted liposomal chemotherapy
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