Interleukin-18 promoter polymorphisms and risk of ischemic stroke
Abstract Ischemic stroke (IS) is a major cause of morbidity and mortality around the world. Interleukin-18 (IL-18) plays an important role in the pathogenesis of IS and IL-18 promoter polymorphisms have been shown to be associated with levels of expression of IL-18. We investigated the association o...
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| Veröffentlicht in: | Brain research bulletin 2010-04, Vol.81 (6), p.590-594 |
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| creator | Zhang, Na Yu, Jin-Tai Yu, Nan-Nan Lu, Rui-Chun Ma, Teng Wang, Nai-Dong Miao, Dan Song, Jing-Hui Tan, Lan |
| description | Abstract Ischemic stroke (IS) is a major cause of morbidity and mortality around the world. Interleukin-18 (IL-18) plays an important role in the pathogenesis of IS and IL-18 promoter polymorphisms have been shown to be associated with levels of expression of IL-18. We investigated the association of two functional polymorphisms in IL-18 promoter, −607C/A (rs1946518) and −137G/C (rs187238), with the risk of ischemic stroke in a Han Chinese population of 423 patients and 384 healthy controls matched for sex and age. The results revealed that the −607C allele was associated with an increased risk of IS with an odds ratios (OR) of 1.358 ( P = 0.002, power = 100%) and the presence of the −137G allele was correlated with increased the risk of IS in the subtype of patients with large artery atherosclerosis (LAA) (OR = 1.583, P = 0.02, power = 94%). Patients with the −607C/−137G haplotype also had significantly increased risk of IS compared to controls (OR = 1.341, P = 0.005, power = 100%). Our findings suggest that these functional polymorphisms in the IL-18 promoter are involved in development of IS in the Han Chinese population. |
| doi_str_mv | 10.1016/j.brainresbull.2010.01.008 |
| format | Article |
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Interleukin-18 (IL-18) plays an important role in the pathogenesis of IS and IL-18 promoter polymorphisms have been shown to be associated with levels of expression of IL-18. We investigated the association of two functional polymorphisms in IL-18 promoter, −607C/A (rs1946518) and −137G/C (rs187238), with the risk of ischemic stroke in a Han Chinese population of 423 patients and 384 healthy controls matched for sex and age. The results revealed that the −607C allele was associated with an increased risk of IS with an odds ratios (OR) of 1.358 ( P = 0.002, power = 100%) and the presence of the −137G allele was correlated with increased the risk of IS in the subtype of patients with large artery atherosclerosis (LAA) (OR = 1.583, P = 0.02, power = 94%). Patients with the −607C/−137G haplotype also had significantly increased risk of IS compared to controls (OR = 1.341, P = 0.005, power = 100%). Our findings suggest that these functional polymorphisms in the IL-18 promoter are involved in development of IS in the Han Chinese population.</description><identifier>ISSN: 0361-9230</identifier><identifier>EISSN: 1873-2747</identifier><identifier>DOI: 10.1016/j.brainresbull.2010.01.008</identifier><identifier>PMID: 20097272</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Alleles ; Asian Continental Ancestry Group - genetics ; Atherosclerosis - genetics ; Brain Ischemia - genetics ; China ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Inflammation ; Interleukin-18 ; Interleukin-18 - genetics ; Ischemic stroke ; Male ; Neurology ; Point Mutation ; Polymorphism, Genetic ; Polymorphisms ; Promoter Regions, Genetic ; Risk ; Stroke - genetics</subject><ispartof>Brain research bulletin, 2010-04, Vol.81 (6), p.590-594</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><rights>Copyright 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-41d9067e60354ca9cfe98ca9ec51a7e444105cd320fca93be973fba834e8d2683</citedby><cites>FETCH-LOGICAL-c466t-41d9067e60354ca9cfe98ca9ec51a7e444105cd320fca93be973fba834e8d2683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.brainresbull.2010.01.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20097272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Na</creatorcontrib><creatorcontrib>Yu, Jin-Tai</creatorcontrib><creatorcontrib>Yu, Nan-Nan</creatorcontrib><creatorcontrib>Lu, Rui-Chun</creatorcontrib><creatorcontrib>Ma, Teng</creatorcontrib><creatorcontrib>Wang, Nai-Dong</creatorcontrib><creatorcontrib>Miao, Dan</creatorcontrib><creatorcontrib>Song, Jing-Hui</creatorcontrib><creatorcontrib>Tan, Lan</creatorcontrib><title>Interleukin-18 promoter polymorphisms and risk of ischemic stroke</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>Abstract Ischemic stroke (IS) is a major cause of morbidity and mortality around the world. Interleukin-18 (IL-18) plays an important role in the pathogenesis of IS and IL-18 promoter polymorphisms have been shown to be associated with levels of expression of IL-18. We investigated the association of two functional polymorphisms in IL-18 promoter, −607C/A (rs1946518) and −137G/C (rs187238), with the risk of ischemic stroke in a Han Chinese population of 423 patients and 384 healthy controls matched for sex and age. The results revealed that the −607C allele was associated with an increased risk of IS with an odds ratios (OR) of 1.358 ( P = 0.002, power = 100%) and the presence of the −137G allele was correlated with increased the risk of IS in the subtype of patients with large artery atherosclerosis (LAA) (OR = 1.583, P = 0.02, power = 94%). Patients with the −607C/−137G haplotype also had significantly increased risk of IS compared to controls (OR = 1.341, P = 0.005, power = 100%). Our findings suggest that these functional polymorphisms in the IL-18 promoter are involved in development of IS in the Han Chinese population.</description><subject>Aged</subject><subject>Alleles</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Atherosclerosis - genetics</subject><subject>Brain Ischemia - genetics</subject><subject>China</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin-18</subject><subject>Interleukin-18 - genetics</subject><subject>Ischemic stroke</subject><subject>Male</subject><subject>Neurology</subject><subject>Point Mutation</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphisms</subject><subject>Promoter Regions, Genetic</subject><subject>Risk</subject><subject>Stroke - genetics</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQhi0EotvCX6iiXjhlO_6I7XBAqgq0lSpxAM6W40xU7zrxYieV9t_j1ZYK9QKnkcbvfD2vCbmgsKZA5eVm3SXrp4S5W0JYMygPQNcA-hVZUa14zZRQr8kKuKR1yzickNOcNwAgdSPfkhMG0Cqm2Ipc3U0zpoDL1k811dUuxTGWTLWLYT_GtHvwecyVnfoq-byt4lD57B5w9K7Kc4pbfEfeDDZkfP8Uz8jPr19-XN_W999u7q6v7msnpJxrQfsWpEIJvBHOtm7AVpeIrqFWoRCCQuN6zmAoWd5hq_jQWc0F6p5Jzc_Ih2PfsuKvBfNsxrIJhmAnjEs2WqlGtqKc-y-l4pxSCaCK8uNR6VLMOeFgdsmPNu0NBXNgbTbmb9bmwNoANYV1KT5_GrN0I_bPpX_gFsHnowALlkePyWTncXLY-4RuNn30_zfn04s2LvjJOxu2uMe8iUuaCnhDTWYGzPeD6wfTafEbyk_gvwE-dquk</recordid><startdate>20100405</startdate><enddate>20100405</enddate><creator>Zhang, Na</creator><creator>Yu, Jin-Tai</creator><creator>Yu, Nan-Nan</creator><creator>Lu, Rui-Chun</creator><creator>Ma, Teng</creator><creator>Wang, Nai-Dong</creator><creator>Miao, Dan</creator><creator>Song, Jing-Hui</creator><creator>Tan, Lan</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope></search><sort><creationdate>20100405</creationdate><title>Interleukin-18 promoter polymorphisms and risk of ischemic stroke</title><author>Zhang, Na ; Yu, Jin-Tai ; Yu, Nan-Nan ; Lu, Rui-Chun ; Ma, Teng ; Wang, Nai-Dong ; Miao, Dan ; Song, Jing-Hui ; Tan, Lan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-41d9067e60354ca9cfe98ca9ec51a7e444105cd320fca93be973fba834e8d2683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Alleles</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Atherosclerosis - genetics</topic><topic>Brain Ischemia - genetics</topic><topic>China</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Interleukin-18</topic><topic>Interleukin-18 - genetics</topic><topic>Ischemic stroke</topic><topic>Male</topic><topic>Neurology</topic><topic>Point Mutation</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphisms</topic><topic>Promoter Regions, Genetic</topic><topic>Risk</topic><topic>Stroke - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Na</creatorcontrib><creatorcontrib>Yu, Jin-Tai</creatorcontrib><creatorcontrib>Yu, Nan-Nan</creatorcontrib><creatorcontrib>Lu, Rui-Chun</creatorcontrib><creatorcontrib>Ma, Teng</creatorcontrib><creatorcontrib>Wang, Nai-Dong</creatorcontrib><creatorcontrib>Miao, Dan</creatorcontrib><creatorcontrib>Song, Jing-Hui</creatorcontrib><creatorcontrib>Tan, Lan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Na</au><au>Yu, Jin-Tai</au><au>Yu, Nan-Nan</au><au>Lu, Rui-Chun</au><au>Ma, Teng</au><au>Wang, Nai-Dong</au><au>Miao, Dan</au><au>Song, Jing-Hui</au><au>Tan, Lan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-18 promoter polymorphisms and risk of ischemic stroke</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>2010-04-05</date><risdate>2010</risdate><volume>81</volume><issue>6</issue><spage>590</spage><epage>594</epage><pages>590-594</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><abstract>Abstract Ischemic stroke (IS) is a major cause of morbidity and mortality around the world. Interleukin-18 (IL-18) plays an important role in the pathogenesis of IS and IL-18 promoter polymorphisms have been shown to be associated with levels of expression of IL-18. We investigated the association of two functional polymorphisms in IL-18 promoter, −607C/A (rs1946518) and −137G/C (rs187238), with the risk of ischemic stroke in a Han Chinese population of 423 patients and 384 healthy controls matched for sex and age. The results revealed that the −607C allele was associated with an increased risk of IS with an odds ratios (OR) of 1.358 ( P = 0.002, power = 100%) and the presence of the −137G allele was correlated with increased the risk of IS in the subtype of patients with large artery atherosclerosis (LAA) (OR = 1.583, P = 0.02, power = 94%). Patients with the −607C/−137G haplotype also had significantly increased risk of IS compared to controls (OR = 1.341, P = 0.005, power = 100%). Our findings suggest that these functional polymorphisms in the IL-18 promoter are involved in development of IS in the Han Chinese population.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20097272</pmid><doi>10.1016/j.brainresbull.2010.01.008</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Alleles Asian Continental Ancestry Group - genetics Atherosclerosis - genetics Brain Ischemia - genetics China Female Genetic Predisposition to Disease Genotype Humans Inflammation Interleukin-18 Interleukin-18 - genetics Ischemic stroke Male Neurology Point Mutation Polymorphism, Genetic Polymorphisms Promoter Regions, Genetic Risk Stroke - genetics |
| title | Interleukin-18 promoter polymorphisms and risk of ischemic stroke |
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