Sulforaphane protects against cisplatin-induced nephrotoxicity

Cisplatin (cis-diamminedichloroplatinum II, CDDP) is a chemotherapeutic agent that induces nephrotoxicity associated with oxidative/nitrosative stress. Sulforaphane (SFN) is an isothiocyanate produced by the enzymatic action of myrosinase on glucorophanin, a glucosinolate contained in cruciferous ve...

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Veröffentlicht in:	Toxicology letters 2010-02, Vol.192 (3), p.278-285
Hauptverfasser:	Guerrero-Beltrán, Carlos Enrique, Calderón-Oliver, Mariel, Tapia, Edilia, Medina-Campos, Omar N., Sánchez-González, Dolores Javier, Martínez-Martínez, Claudia María, Ortiz-Vega, Karla Mariana, Franco, Martha, Pedraza-Chaverri, José
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Animals Anticarcinogenic Agents - pharmacology Antineoplastic Agents - adverse effects Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cell Death - drug effects Cell Nucleus - metabolism Cell Survival - drug effects Chemical agents Cisplatin Cisplatin - adverse effects Dose-Response Relationship, Drug Isothiocyanates Kidney - cytology Kidney - drug effects LLC-PK1 Cells Male Medical sciences Nephrotoxicity NF-E2-Related Factor 2 - drug effects NF-E2-Related Factor 2 - metabolism Nrf2 Oxidative Stress - drug effects Oxidative/nitrosative stress Rats Rats, Wistar Renoprotection Sulforaphane Swine Thiocyanates - pharmacology Toxicology Tumors
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