Prevalence and Impact of Coronary Artery Disease in Patients With Pulmonary Arterial Hypertension
The occurrence and impact of coronary artery disease (CAD) among patients with pulmonary arterial hypertension (PAH) are unknown. We aimed to determine the prevalence, clinical correlates, and effect of CAD in patients with PAH. We reviewed the medical records of consecutive patients diagnosed with...
Gespeichert in:
| Veröffentlicht in: | The American journal of cardiology 2011-08, Vol.108 (3), p.460-464 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 464 |
|---|---|
| container_issue | 3 |
| container_start_page | 460 |
| container_title | The American journal of cardiology |
| container_volume | 108 |
| creator | Shimony, Avi, MD Eisenberg, Mark Jeffrey, MD, MPH Rudski, Lawrence Glenn, MD Schlesinger, Robert, MD Afilalo, Jonathan, MD, MSc Joyal, Dominique, MD Dragatakis, Leonidas, MD Hirsch, Andrew, MD Boutet, Kim, MD Fox, Benjamin Daniel, MD Langleben, David, MD |
| description | The occurrence and impact of coronary artery disease (CAD) among patients with pulmonary arterial hypertension (PAH) are unknown. We aimed to determine the prevalence, clinical correlates, and effect of CAD in patients with PAH. We reviewed the medical records of consecutive patients diagnosed with PAH at a university-based referral center for pulmonary vascular disease from January 1990 to May 2010. The patients systematically underwent right heart catheterization and coronary angiography as a part of their evaluation. The patients with PAH with CAD (defined as ≥50% stenosis in ≥1 major epicardial coronary artery) were compared to patients without CAD. Among the 162 patients with PAH, the prevalence of CAD was 28.4%. The presence of CAD was associated with older age (66.6 ± 11.5 vs 49.2 ± 14.0 years, p |
| doi_str_mv | 10.1016/j.amjcard.2011.03.066 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_877415288</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0002914911013610</els_id><sourcerecordid>877415288</sourcerecordid><originalsourceid>FETCH-LOGICAL-c476t-150bbd2942c6f1f3bfed725d2e276f2e26f18386b1ab702a4abee71e33b1ef633</originalsourceid><addsrcrecordid>eNqFklGL1DAQx4Mo3nr6EZQgiE-tmaRN2hflWO-8gwMXVHwMaTrF1DZdk_Zgv70pu55yL75kkvCbf2bmH0JeAsuBgXzX52bsrQltzhlAzkTOpHxENlCpOoMaxGOyYYzxrIaiPiPPYuzTEaCUT8kZB8lYKcSGmF3AOzOgt0iNb-nNuDd2plNHt1OYvAkHehFmTOGji2giUufpzswO_Rzpdzf_oLtlGP8hnRno9WGPae-jm_xz8qQzQ8QXp3hOvl1dft1eZ7efP91sL24zWyg5Z1Cypml5XXArO-hE02GreNly5Ep2aU23lahkA6ZRjJvCNIgKUIgGsJNCnJO3R919mH4tGGc9umhxGIzHaYm6UqqAkldVIl8_IPtpCT4Vp6uK1WUtq1WuPEI2TDEG7PQ-uDF1qYHp1QHd65MDenVAM6GTAynv1Ul8aUZs77P-jDwBb06AidYMXTDeuviXKwpeKFi5D0cO09DuHAYdrVt9al1AO-t2cv8t5f0DBTs479KjP_GA8b5p0JFrpr-s32X9LZA0hQQmfgPohrt_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>880959683</pqid></control><display><type>article</type><title>Prevalence and Impact of Coronary Artery Disease in Patients With Pulmonary Arterial Hypertension</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Shimony, Avi, MD ; Eisenberg, Mark Jeffrey, MD, MPH ; Rudski, Lawrence Glenn, MD ; Schlesinger, Robert, MD ; Afilalo, Jonathan, MD, MSc ; Joyal, Dominique, MD ; Dragatakis, Leonidas, MD ; Hirsch, Andrew, MD ; Boutet, Kim, MD ; Fox, Benjamin Daniel, MD ; Langleben, David, MD</creator><creatorcontrib>Shimony, Avi, MD ; Eisenberg, Mark Jeffrey, MD, MPH ; Rudski, Lawrence Glenn, MD ; Schlesinger, Robert, MD ; Afilalo, Jonathan, MD, MSc ; Joyal, Dominique, MD ; Dragatakis, Leonidas, MD ; Hirsch, Andrew, MD ; Boutet, Kim, MD ; Fox, Benjamin Daniel, MD ; Langleben, David, MD</creatorcontrib><description>The occurrence and impact of coronary artery disease (CAD) among patients with pulmonary arterial hypertension (PAH) are unknown. We aimed to determine the prevalence, clinical correlates, and effect of CAD in patients with PAH. We reviewed the medical records of consecutive patients diagnosed with PAH at a university-based referral center for pulmonary vascular disease from January 1990 to May 2010. The patients systematically underwent right heart catheterization and coronary angiography as a part of their evaluation. The patients with PAH with CAD (defined as ≥50% stenosis in ≥1 major epicardial coronary artery) were compared to patients without CAD. Among the 162 patients with PAH, the prevalence of CAD was 28.4%. The presence of CAD was associated with older age (66.6 ± 11.5 vs 49.2 ± 14.0 years, p <0.001), systemic hypertension, and dyslipidemia. The patients with PAH and CAD had a lower mean pulmonary arterial pressure (44.6 ± 11.1 vs 49.2 ± 14.0 mm Hg; p = 0.02) than patients without CAD. During a median follow-up of 36 months, 73 patients died. The presence of CAD was a predictor of all-cause mortality on univariate analysis (hazard ratio 1.97, 95% confidence interval 1.21 to 3.20) but not on multivariate analysis, which identified older age (hazard ratio 1.03, 95% confidence interval 1.01 to 1.05) and right atrial pressure (hazard ratio 1.08, 95% confidence interval 1.03 to 1.14) as the only independent predictors. In conclusion, our study has demonstrated that CAD is common among patients with PAH. CAD prevalence increases with age, dyslipidemia, and hypertension, but we did not detect an independent prognostic effect of CAD on mortality.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2011.03.066</identifier><identifier>PMID: 21600533</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Age Factors ; Aged ; Biological and medical sciences ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Cohort Studies ; Comorbidity ; Coronary Angiography ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - etiology ; Coronary Artery Disease - mortality ; Coronary heart disease ; Cross-Sectional Studies ; Female ; Heart ; Humans ; Hypertension, Pulmonary - diagnosis ; Hypertension, Pulmonary - etiology ; Hypertension, Pulmonary - mortality ; Intubation ; Kaplan-Meier Estimate ; Male ; Medical sciences ; Middle Aged ; Multivariate analysis ; Patients ; Pneumology ; Prognosis ; Proportional Hazards Models ; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases ; Registries ; Risk Factors ; Survival Rate</subject><ispartof>The American journal of cardiology, 2011-08, Vol.108 (3), p.460-464</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Sequoia S.A. Aug 1, 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-150bbd2942c6f1f3bfed725d2e276f2e26f18386b1ab702a4abee71e33b1ef633</citedby><cites>FETCH-LOGICAL-c476t-150bbd2942c6f1f3bfed725d2e276f2e26f18386b1ab702a4abee71e33b1ef633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002914911013610$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24424713$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21600533$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimony, Avi, MD</creatorcontrib><creatorcontrib>Eisenberg, Mark Jeffrey, MD, MPH</creatorcontrib><creatorcontrib>Rudski, Lawrence Glenn, MD</creatorcontrib><creatorcontrib>Schlesinger, Robert, MD</creatorcontrib><creatorcontrib>Afilalo, Jonathan, MD, MSc</creatorcontrib><creatorcontrib>Joyal, Dominique, MD</creatorcontrib><creatorcontrib>Dragatakis, Leonidas, MD</creatorcontrib><creatorcontrib>Hirsch, Andrew, MD</creatorcontrib><creatorcontrib>Boutet, Kim, MD</creatorcontrib><creatorcontrib>Fox, Benjamin Daniel, MD</creatorcontrib><creatorcontrib>Langleben, David, MD</creatorcontrib><title>Prevalence and Impact of Coronary Artery Disease in Patients With Pulmonary Arterial Hypertension</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>The occurrence and impact of coronary artery disease (CAD) among patients with pulmonary arterial hypertension (PAH) are unknown. We aimed to determine the prevalence, clinical correlates, and effect of CAD in patients with PAH. We reviewed the medical records of consecutive patients diagnosed with PAH at a university-based referral center for pulmonary vascular disease from January 1990 to May 2010. The patients systematically underwent right heart catheterization and coronary angiography as a part of their evaluation. The patients with PAH with CAD (defined as ≥50% stenosis in ≥1 major epicardial coronary artery) were compared to patients without CAD. Among the 162 patients with PAH, the prevalence of CAD was 28.4%. The presence of CAD was associated with older age (66.6 ± 11.5 vs 49.2 ± 14.0 years, p <0.001), systemic hypertension, and dyslipidemia. The patients with PAH and CAD had a lower mean pulmonary arterial pressure (44.6 ± 11.1 vs 49.2 ± 14.0 mm Hg; p = 0.02) than patients without CAD. During a median follow-up of 36 months, 73 patients died. The presence of CAD was a predictor of all-cause mortality on univariate analysis (hazard ratio 1.97, 95% confidence interval 1.21 to 3.20) but not on multivariate analysis, which identified older age (hazard ratio 1.03, 95% confidence interval 1.01 to 1.05) and right atrial pressure (hazard ratio 1.08, 95% confidence interval 1.03 to 1.14) as the only independent predictors. In conclusion, our study has demonstrated that CAD is common among patients with PAH. CAD prevalence increases with age, dyslipidemia, and hypertension, but we did not detect an independent prognostic effect of CAD on mortality.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Coronary Angiography</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - etiology</subject><subject>Coronary Artery Disease - mortality</subject><subject>Coronary heart disease</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - diagnosis</subject><subject>Hypertension, Pulmonary - etiology</subject><subject>Hypertension, Pulmonary - mortality</subject><subject>Intubation</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Patients</subject><subject>Pneumology</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>Survival Rate</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFklGL1DAQx4Mo3nr6EZQgiE-tmaRN2hflWO-8gwMXVHwMaTrF1DZdk_Zgv70pu55yL75kkvCbf2bmH0JeAsuBgXzX52bsrQltzhlAzkTOpHxENlCpOoMaxGOyYYzxrIaiPiPPYuzTEaCUT8kZB8lYKcSGmF3AOzOgt0iNb-nNuDd2plNHt1OYvAkHehFmTOGji2giUufpzswO_Rzpdzf_oLtlGP8hnRno9WGPae-jm_xz8qQzQ8QXp3hOvl1dft1eZ7efP91sL24zWyg5Z1Cypml5XXArO-hE02GreNly5Ep2aU23lahkA6ZRjJvCNIgKUIgGsJNCnJO3R919mH4tGGc9umhxGIzHaYm6UqqAkldVIl8_IPtpCT4Vp6uK1WUtq1WuPEI2TDEG7PQ-uDF1qYHp1QHd65MDenVAM6GTAynv1Ul8aUZs77P-jDwBb06AidYMXTDeuviXKwpeKFi5D0cO09DuHAYdrVt9al1AO-t2cv8t5f0DBTs479KjP_GA8b5p0JFrpr-s32X9LZA0hQQmfgPohrt_</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Shimony, Avi, MD</creator><creator>Eisenberg, Mark Jeffrey, MD, MPH</creator><creator>Rudski, Lawrence Glenn, MD</creator><creator>Schlesinger, Robert, MD</creator><creator>Afilalo, Jonathan, MD, MSc</creator><creator>Joyal, Dominique, MD</creator><creator>Dragatakis, Leonidas, MD</creator><creator>Hirsch, Andrew, MD</creator><creator>Boutet, Kim, MD</creator><creator>Fox, Benjamin Daniel, MD</creator><creator>Langleben, David, MD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20110801</creationdate><title>Prevalence and Impact of Coronary Artery Disease in Patients With Pulmonary Arterial Hypertension</title><author>Shimony, Avi, MD ; Eisenberg, Mark Jeffrey, MD, MPH ; Rudski, Lawrence Glenn, MD ; Schlesinger, Robert, MD ; Afilalo, Jonathan, MD, MSc ; Joyal, Dominique, MD ; Dragatakis, Leonidas, MD ; Hirsch, Andrew, MD ; Boutet, Kim, MD ; Fox, Benjamin Daniel, MD ; Langleben, David, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-150bbd2942c6f1f3bfed725d2e276f2e26f18386b1ab702a4abee71e33b1ef633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Coronary Angiography</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Artery Disease - etiology</topic><topic>Coronary Artery Disease - mortality</topic><topic>Coronary heart disease</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - diagnosis</topic><topic>Hypertension, Pulmonary - etiology</topic><topic>Hypertension, Pulmonary - mortality</topic><topic>Intubation</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Patients</topic><topic>Pneumology</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimony, Avi, MD</creatorcontrib><creatorcontrib>Eisenberg, Mark Jeffrey, MD, MPH</creatorcontrib><creatorcontrib>Rudski, Lawrence Glenn, MD</creatorcontrib><creatorcontrib>Schlesinger, Robert, MD</creatorcontrib><creatorcontrib>Afilalo, Jonathan, MD, MSc</creatorcontrib><creatorcontrib>Joyal, Dominique, MD</creatorcontrib><creatorcontrib>Dragatakis, Leonidas, MD</creatorcontrib><creatorcontrib>Hirsch, Andrew, MD</creatorcontrib><creatorcontrib>Boutet, Kim, MD</creatorcontrib><creatorcontrib>Fox, Benjamin Daniel, MD</creatorcontrib><creatorcontrib>Langleben, David, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimony, Avi, MD</au><au>Eisenberg, Mark Jeffrey, MD, MPH</au><au>Rudski, Lawrence Glenn, MD</au><au>Schlesinger, Robert, MD</au><au>Afilalo, Jonathan, MD, MSc</au><au>Joyal, Dominique, MD</au><au>Dragatakis, Leonidas, MD</au><au>Hirsch, Andrew, MD</au><au>Boutet, Kim, MD</au><au>Fox, Benjamin Daniel, MD</au><au>Langleben, David, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and Impact of Coronary Artery Disease in Patients With Pulmonary Arterial Hypertension</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>108</volume><issue>3</issue><spage>460</spage><epage>464</epage><pages>460-464</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>The occurrence and impact of coronary artery disease (CAD) among patients with pulmonary arterial hypertension (PAH) are unknown. We aimed to determine the prevalence, clinical correlates, and effect of CAD in patients with PAH. We reviewed the medical records of consecutive patients diagnosed with PAH at a university-based referral center for pulmonary vascular disease from January 1990 to May 2010. The patients systematically underwent right heart catheterization and coronary angiography as a part of their evaluation. The patients with PAH with CAD (defined as ≥50% stenosis in ≥1 major epicardial coronary artery) were compared to patients without CAD. Among the 162 patients with PAH, the prevalence of CAD was 28.4%. The presence of CAD was associated with older age (66.6 ± 11.5 vs 49.2 ± 14.0 years, p <0.001), systemic hypertension, and dyslipidemia. The patients with PAH and CAD had a lower mean pulmonary arterial pressure (44.6 ± 11.1 vs 49.2 ± 14.0 mm Hg; p = 0.02) than patients without CAD. During a median follow-up of 36 months, 73 patients died. The presence of CAD was a predictor of all-cause mortality on univariate analysis (hazard ratio 1.97, 95% confidence interval 1.21 to 3.20) but not on multivariate analysis, which identified older age (hazard ratio 1.03, 95% confidence interval 1.01 to 1.05) and right atrial pressure (hazard ratio 1.08, 95% confidence interval 1.03 to 1.14) as the only independent predictors. In conclusion, our study has demonstrated that CAD is common among patients with PAH. CAD prevalence increases with age, dyslipidemia, and hypertension, but we did not detect an independent prognostic effect of CAD on mortality.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21600533</pmid><doi>10.1016/j.amjcard.2011.03.066</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9149 |
| ispartof | The American journal of cardiology, 2011-08, Vol.108 (3), p.460-464 |
| issn | 0002-9149 1879-1913 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_877415288 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Age Factors Aged Biological and medical sciences Cardiology Cardiology. Vascular system Cardiovascular Cardiovascular disease Cohort Studies Comorbidity Coronary Angiography Coronary Artery Disease - diagnosis Coronary Artery Disease - etiology Coronary Artery Disease - mortality Coronary heart disease Cross-Sectional Studies Female Heart Humans Hypertension, Pulmonary - diagnosis Hypertension, Pulmonary - etiology Hypertension, Pulmonary - mortality Intubation Kaplan-Meier Estimate Male Medical sciences Middle Aged Multivariate analysis Patients Pneumology Prognosis Proportional Hazards Models Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Registries Risk Factors Survival Rate |
| title | Prevalence and Impact of Coronary Artery Disease in Patients With Pulmonary Arterial Hypertension |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T22%3A56%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence%20and%20Impact%20of%20Coronary%20Artery%20Disease%20in%20Patients%20With%20Pulmonary%20Arterial%20Hypertension&rft.jtitle=The%20American%20journal%20of%20cardiology&rft.au=Shimony,%20Avi,%20MD&rft.date=2011-08-01&rft.volume=108&rft.issue=3&rft.spage=460&rft.epage=464&rft.pages=460-464&rft.issn=0002-9149&rft.eissn=1879-1913&rft.coden=AJCDAG&rft_id=info:doi/10.1016/j.amjcard.2011.03.066&rft_dat=%3Cproquest_cross%3E877415288%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=880959683&rft_id=info:pmid/21600533&rft_els_id=1_s2_0_S0002914911013610&rfr_iscdi=true |