Trp-Trp pairs as β-hairpin stabilisers: hydrogen-bonded versus non-hydrogen-bonded sites
Trp-Trp pairs have emerged as a successful strategy for β-hairpin stabilization. Using loop 3 of Vammin as a template, we experimentally demonstrate that the contribution of Trp-Trp pairs to β-hairpin stability depends on β-sheet periodicity, that is, they are stabilising at non-hydrogen-bonded site...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2011-08, Vol.9 (15), p.5487-5492 |
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| container_end_page | 5492 |
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| container_issue | 15 |
| container_start_page | 5487 |
| container_title | Organic & biomolecular chemistry |
| container_volume | 9 |
| creator | Santiveri, Clara M Pérez de Vega, María Jesús González-Muñiz, Rosario Jiménez, M Angeles |
| description | Trp-Trp pairs have emerged as a successful strategy for β-hairpin stabilization. Using loop 3 of Vammin as a template, we experimentally demonstrate that the contribution of Trp-Trp pairs to β-hairpin stability depends on β-sheet periodicity, that is, they are stabilising at non-hydrogen-bonded sites, but not at hydrogen-bonded positions. |
| doi_str_mv | 10.1039/c1ob05353a |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Organic & biomolecular chemistry, 2011-08, Vol.9 (15), p.5487-5492 |
| issn | 1477-0520 1477-0539 |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Binding Sites Hydrogen - chemistry Hydrogen Bonding Models, Molecular Protein Folding Protein Structure, Secondary Tryptophan - chemistry |
| title | Trp-Trp pairs as β-hairpin stabilisers: hydrogen-bonded versus non-hydrogen-bonded sites |
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