Caspase expression in oral squamous cell carcinoma
Background Apoptosis is a genetically programmed form of cell death, of which caspases are the central components. Methods By tissue microarray of 229 cases of oral squamous cell carcinoma (OSCC), we analyzed the immunoexpression of caspases 3, 6, 7, 8, 9, and 10. Results All proteins that we examin...
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| Veröffentlicht in: | Head & neck 2011-08, Vol.33 (8), p.1191-1198 |
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| creator | Coutinho-Camillo, Cláudia Malheiros Lourenço, Silvia Vanessa Nishimoto, Ines Nobuko Kowalski, Luiz Paulo Soares, Fernando Augusto |
| description | Background
Apoptosis is a genetically programmed form of cell death, of which caspases are the central components.
Methods
By tissue microarray of 229 cases of oral squamous cell carcinoma (OSCC), we analyzed the immunoexpression of caspases 3, 6, 7, 8, 9, and 10.
Results
All proteins that we examined were expressed in primary OSCC samples. Caspases 8 and 9 were prominently expressed, and caspases 3, 6, 7, and 10 were occasionally expressed. Disease‐free survival differed significantly between caspase 7 high‐expressing and low‐expressing patients, and our multivariate analysis suggested that expression of caspase 7 is an independent prognostic factor for patients with OSCC.
Conclusion
This study suggests that caspases regulate the tumorigenesis of OSCC and that caspase 7 expression is a predictor of locoregional recurrence of OSCC. © 2010 Wiley Periodicals, Inc. Head Neck, 2011 |
| doi_str_mv | 10.1002/hed.21602 |
| format | Article |
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Apoptosis is a genetically programmed form of cell death, of which caspases are the central components.
Methods
By tissue microarray of 229 cases of oral squamous cell carcinoma (OSCC), we analyzed the immunoexpression of caspases 3, 6, 7, 8, 9, and 10.
Results
All proteins that we examined were expressed in primary OSCC samples. Caspases 8 and 9 were prominently expressed, and caspases 3, 6, 7, and 10 were occasionally expressed. Disease‐free survival differed significantly between caspase 7 high‐expressing and low‐expressing patients, and our multivariate analysis suggested that expression of caspase 7 is an independent prognostic factor for patients with OSCC.
Conclusion
This study suggests that caspases regulate the tumorigenesis of OSCC and that caspase 7 expression is a predictor of locoregional recurrence of OSCC. © 2010 Wiley Periodicals, Inc. Head Neck, 2011</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.21602</identifier><identifier>PMID: 21755562</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; apoptosis ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Biopsy, Needle ; Carcinoma, Squamous Cell - enzymology ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Case-Control Studies ; caspases ; Caspases - genetics ; Caspases - metabolism ; Disease Progression ; Disease-Free Survival ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; Medical sciences ; Microarray Analysis - methods ; Middle Aged ; Mouth Neoplasms - enzymology ; Mouth Neoplasms - genetics ; Mouth Neoplasms - mortality ; Mouth Neoplasms - pathology ; Neoplasm Staging ; oral squamous cell carcinoma ; Otorhinolaryngology. Stomatology ; Predictive Value of Tests ; Prognosis ; Proportional Hazards Models ; Reference Values ; Survival Analysis ; Tissue Embedding ; tissue microarray ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Head & neck, 2011-08, Vol.33 (8), p.1191-1198</ispartof><rights>Copyright © 2010 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4582-3cae933d40c0e76f57f6932e1ca15c6f26ac53107a0f64dd5d4d5788f4bf3b563</citedby><cites>FETCH-LOGICAL-c4582-3cae933d40c0e76f57f6932e1ca15c6f26ac53107a0f64dd5d4d5788f4bf3b563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.21602$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.21602$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24384647$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21755562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coutinho-Camillo, Cláudia Malheiros</creatorcontrib><creatorcontrib>Lourenço, Silvia Vanessa</creatorcontrib><creatorcontrib>Nishimoto, Ines Nobuko</creatorcontrib><creatorcontrib>Kowalski, Luiz Paulo</creatorcontrib><creatorcontrib>Soares, Fernando Augusto</creatorcontrib><title>Caspase expression in oral squamous cell carcinoma</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Apoptosis is a genetically programmed form of cell death, of which caspases are the central components.
Methods
By tissue microarray of 229 cases of oral squamous cell carcinoma (OSCC), we analyzed the immunoexpression of caspases 3, 6, 7, 8, 9, and 10.
Results
All proteins that we examined were expressed in primary OSCC samples. Caspases 8 and 9 were prominently expressed, and caspases 3, 6, 7, and 10 were occasionally expressed. Disease‐free survival differed significantly between caspase 7 high‐expressing and low‐expressing patients, and our multivariate analysis suggested that expression of caspase 7 is an independent prognostic factor for patients with OSCC.
Conclusion
This study suggests that caspases regulate the tumorigenesis of OSCC and that caspase 7 expression is a predictor of locoregional recurrence of OSCC. © 2010 Wiley Periodicals, Inc. Head Neck, 2011</description><subject>Adult</subject><subject>Aged</subject><subject>apoptosis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biopsy, Needle</subject><subject>Carcinoma, Squamous Cell - enzymology</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Case-Control Studies</subject><subject>caspases</subject><subject>Caspases - genetics</subject><subject>Caspases - metabolism</subject><subject>Disease Progression</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microarray Analysis - methods</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - enzymology</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mouth Neoplasms - mortality</subject><subject>Mouth Neoplasms - pathology</subject><subject>Neoplasm Staging</subject><subject>oral squamous cell carcinoma</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Reference Values</subject><subject>Survival Analysis</subject><subject>Tissue Embedding</subject><subject>tissue microarray</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MlOIzEQBmALgVgCB14A9QUhDg1lu2x3jqMEwojtAoKbVXHboqGXYBMBbz-dSTJz4uSS9dWin7FDDmccQJy_-PJMcA1ig-1yGJocJJrNRY0yl2Bwh-2l9AoAUqPYZjuCG6WUFrtMjCjNKPnMf82iT6nq2qxqsy5SnaX3OTXdPGXO13XmKLqq7RraZ1uB6uQPVu-APV5ePIyu8pv7ye_Rr5vcoSpELh35oZQlggNvdFAm6KEUnjviyukgNDklORiCoLEsVYmlMkURcBrkVGk5YCfLubPYvc99-rBNlRanUOv7q2xhDAIiQi9Pl9LFLqXog53FqqH4bTnYRUK2T8j-Tai3R6up82nT_67lOpIeHK8AJUd1iNS6Kv13KAvUaHp3vnSfVe2_f95ory7G69X5sqNKH_7rXwfFN6uNNMo-3U0sjsfj5-sHtLfyD9x_ilI</recordid><startdate>201108</startdate><enddate>201108</enddate><creator>Coutinho-Camillo, Cláudia Malheiros</creator><creator>Lourenço, Silvia Vanessa</creator><creator>Nishimoto, Ines Nobuko</creator><creator>Kowalski, Luiz Paulo</creator><creator>Soares, Fernando Augusto</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201108</creationdate><title>Caspase expression in oral squamous cell carcinoma</title><author>Coutinho-Camillo, Cláudia Malheiros ; Lourenço, Silvia Vanessa ; Nishimoto, Ines Nobuko ; Kowalski, Luiz Paulo ; Soares, Fernando Augusto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4582-3cae933d40c0e76f57f6932e1ca15c6f26ac53107a0f64dd5d4d5788f4bf3b563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>apoptosis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biopsy, Needle</topic><topic>Carcinoma, Squamous Cell - enzymology</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Case-Control Studies</topic><topic>caspases</topic><topic>Caspases - genetics</topic><topic>Caspases - metabolism</topic><topic>Disease Progression</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microarray Analysis - methods</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - enzymology</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mouth Neoplasms - mortality</topic><topic>Mouth Neoplasms - pathology</topic><topic>Neoplasm Staging</topic><topic>oral squamous cell carcinoma</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Reference Values</topic><topic>Survival Analysis</topic><topic>Tissue Embedding</topic><topic>tissue microarray</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coutinho-Camillo, Cláudia Malheiros</creatorcontrib><creatorcontrib>Lourenço, Silvia Vanessa</creatorcontrib><creatorcontrib>Nishimoto, Ines Nobuko</creatorcontrib><creatorcontrib>Kowalski, Luiz Paulo</creatorcontrib><creatorcontrib>Soares, Fernando Augusto</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coutinho-Camillo, Cláudia Malheiros</au><au>Lourenço, Silvia Vanessa</au><au>Nishimoto, Ines Nobuko</au><au>Kowalski, Luiz Paulo</au><au>Soares, Fernando Augusto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Caspase expression in oral squamous cell carcinoma</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2011-08</date><risdate>2011</risdate><volume>33</volume><issue>8</issue><spage>1191</spage><epage>1198</epage><pages>1191-1198</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Apoptosis is a genetically programmed form of cell death, of which caspases are the central components.
Methods
By tissue microarray of 229 cases of oral squamous cell carcinoma (OSCC), we analyzed the immunoexpression of caspases 3, 6, 7, 8, 9, and 10.
Results
All proteins that we examined were expressed in primary OSCC samples. Caspases 8 and 9 were prominently expressed, and caspases 3, 6, 7, and 10 were occasionally expressed. Disease‐free survival differed significantly between caspase 7 high‐expressing and low‐expressing patients, and our multivariate analysis suggested that expression of caspase 7 is an independent prognostic factor for patients with OSCC.
Conclusion
This study suggests that caspases regulate the tumorigenesis of OSCC and that caspase 7 expression is a predictor of locoregional recurrence of OSCC. © 2010 Wiley Periodicals, Inc. Head Neck, 2011</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21755562</pmid><doi>10.1002/hed.21602</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged apoptosis Biological and medical sciences Biomarkers, Tumor - analysis Biopsy, Needle Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Case-Control Studies caspases Caspases - genetics Caspases - metabolism Disease Progression Disease-Free Survival Female Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Kaplan-Meier Estimate Male Medical sciences Microarray Analysis - methods Middle Aged Mouth Neoplasms - enzymology Mouth Neoplasms - genetics Mouth Neoplasms - mortality Mouth Neoplasms - pathology Neoplasm Staging oral squamous cell carcinoma Otorhinolaryngology. Stomatology Predictive Value of Tests Prognosis Proportional Hazards Models Reference Values Survival Analysis Tissue Embedding tissue microarray Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Caspase expression in oral squamous cell carcinoma |
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