The Nodal Inhibitor Coco Is a Critical Target of Leftward Flow in Xenopus

Vertebrate laterality, which is manifested by asymmetrically placed organs [ 1], depends on asymmetric activation of the Nodal signaling cascade in the left lateral plate mesoderm [ 2]. In fish, amphibians, and mammals, a cilia-driven leftward flow of extracellular fluid acts upstream of the Nodal c...

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Veröffentlicht in:	Current biology 2010-04, Vol.20 (8), p.738-743
Hauptverfasser:	Schweickert, Axel, Vick, Philipp, Getwan, Maike, Weber, Thomas, Schneider, Isabelle, Eberhardt, Melanie, Beyer, Tina, Pachur, Anke, Blum, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DEVBIO Embryo, Nonmammalian - cytology Embryo, Nonmammalian - physiology Embryonic Induction Morphogenesis - physiology Nodal Protein - antagonists & inhibitors Nodal Protein - metabolism Signal Transduction - physiology SIGNALING Xenopus Xenopus laevis - anatomy & histology Xenopus laevis - embryology Xenopus Proteins - genetics Xenopus Proteins - metabolism
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