Vacuolar H+-ATPase c protects glial cell death induced by sodium nitroprusside under glutathione-depleted condition

We examined the role of the c subunit (ATP6L) of vacuolar H+‐ATPase and its molecular mechanisms in glial cell death induced by sodium nitroprusside (SNP). ATP6L siRNA‐transfected cells treated with SNP showed a significant increase in cytotoxicity under glutathione (GSH)‐depleted conditions after p...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of cellular biochemistry 2011-08, Vol.112 (8), p.1985-1996
Hauptverfasser:	Byun, Yu Jeong, Lee, Seong-Beom, Lee, Hwa Ok, Son, Min Jeong, Kim, Ho-Shik, Kwon, Oh-Joo, Jeong, Seong-Whan
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP6L Autophagy Autophagy - drug effects Autophagy - genetics Buthionine Sulfoximine - pharmacology Cell Line, Tumor Enzyme Activation - drug effects Enzyme Activation - genetics GLIA Glutathione Humans Hydrogen-Ion Concentration Lysosomes - enzymology Lysosomes - ultrastructure MAPK Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism Neuroglia - enzymology Neuroglia - ultrastructure Nitric Oxide Donors - pharmacology Nitroprusside - pharmacology Oxidation-Reduction - drug effects Protein Kinase Inhibitors - pharmacology Reactive Oxygen Species - metabolism RNA, Small Interfering - genetics Sodium nitroprusside Vacuolar Proton-Translocating ATPases - antagonists & inhibitors Vacuolar Proton-Translocating ATPases - genetics Vacuolar Proton-Translocating ATPases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!