Central nervous system‐specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction

Cap’n’Collar (CNC) proteins heterodimerize with small Maf proteins and regulate the transcription of various genes. Small Maf‐deficient mice develop severe neurodegeneration, and it remains unclear whether CNC proteins are involved in this process. In this study, we examined the contribution of Nrf1...

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Veröffentlicht in:	Genes to cells : devoted to molecular & cellular mechanisms 2011-06, Vol.16 (6), p.692-703
Hauptverfasser:	Kobayashi, Akira, Tsukide, Takako, Miyasaka, Tomohiro, Morita, Tomoko, Mizoroki, Tatsuya, Saito, Yoshiro, Ihara, Yasuo, Takashima, Akihiko, Noguchi, Noriko, Fukamizu, Akiyoshi, Hirotsu, Yosuke, Ohtsuji, Makiko, Katsuoka, Fumiki, Yamamoto, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxia Ataxia - genetics Central nervous system Central Nervous System - metabolism Central Nervous System - physiopathology Embryos Gene Deletion Gene Expression Regulation - genetics Hippocampus Homeostasis Maf protein Mice Mice, Knockout Motor Neurons - metabolism Motor Neurons - pathology Nerve Degeneration - genetics Nerve Degeneration - pathology Neurodegeneration NRF1 gene Nuclear Respiratory Factor 1 - genetics Nuclear Respiratory Factor 1 - metabolism Oxidative stress Oxidative Stress - genetics Phenotype Spinal cord Transcription factors Ubiquitinated Proteins - metabolism
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