CB-1 receptors modulate the effect of the selective serotonin reuptake inhibitor, citalopram on extracellular serotonin levels in the rat prefrontal cortex
► CB-1 receptor modulates the effect of citalopram. ► CB-1 stimulation blocks the effect of citalopram on increasing rat prefrontal cortex 5-HT levels. ► CB-1 blockade potentiates the effect of citalopram on increasing rat prefrontal cortex 5-HT levels. A large percentage of depressed individuals us...
Gespeichert in:
| Veröffentlicht in: | Neuroscience research 2011-07, Vol.70 (3), p.334-337 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 337 |
|---|---|
| container_issue | 3 |
| container_start_page | 334 |
| container_title | Neuroscience research |
| container_volume | 70 |
| creator | Kleijn, Jelle Cremers, Thomas I.F.H. Hofland, Corry M. Westerink, Ben H.C. |
| description | ► CB-1 receptor modulates the effect of citalopram. ► CB-1 stimulation blocks the effect of citalopram on increasing rat prefrontal cortex 5-HT levels. ► CB-1 blockade potentiates the effect of citalopram on increasing rat prefrontal cortex 5-HT levels.
A large percentage of depressed individuals use drugs of abuse, like cannabis. This study investigates the impact of cannabis on the pharmacological effects of the antidepressant citalopram. Using microdialysis in the prefrontal cortex of rats we monitored serotonin levels before and after cannabinoid (WIN55,212-2 or rimonabant) and citalopram administration. Stimulating CB-1 decreased the effect of citalopram on increasing serotonin levels in the prefrontal cortex. Blocking CB-1 augmented this effect of citalopram. Although repeating these experiments in a chronical setting is recommended the present results might have implication for the clinical effects of citalopram. |
| doi_str_mv | 10.1016/j.neures.2011.03.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_876248636</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0168010211000587</els_id><sourcerecordid>876248636</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-4bcde0fb48d7e17b6dfdea679ed278fa79450c19402dbf1b0e4bdba8b6f6b2ba3</originalsourceid><addsrcrecordid>eNp9kctu1DAUhi0EokPLG1TIOzYkHDsml02ldsRNqsSGri1fjlVPkzi1nVF5Fl4WT6egrljZlv7vP0f-CDlnUDNg7cddPeMaMdUcGKuhqQHEC7JhfcernjH2kmxKrK-AAT8hb1LaAUAziOY1OeFMcBBi2JDf26uK0YgGlxxiolOw66gy0nyLFJ1Dk2lwj6-EY3n5_eEWQw6znwu4LlndIfXzrde-VHygxmc1hiWqiYaZ4kOOyuA4ltr4jBxxj2Mq3GN3VJkuEV0Mc4GpCTHjwxl55dSY8O3TeUpuvnz-uf1WXf_4-n17eV0ZwbpcCW0sgtOitx2yTrfWWVRtN6DlXe9UN4hPYNgggFvtmAYU2mrV69a1mmvVnJL3x94lhvsVU5aTT4eV1YxhTbLvWi76tmlLUhyTJoaUyr5yiX5S8ZdkIA9W5E4erciDFQmNLFYK9u5pwKontP-gvxpK4OIYKF-Ce49RJuNxNmh9UZOlDf7_E_4AUjildw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>876248636</pqid></control><display><type>article</type><title>CB-1 receptors modulate the effect of the selective serotonin reuptake inhibitor, citalopram on extracellular serotonin levels in the rat prefrontal cortex</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Kleijn, Jelle ; Cremers, Thomas I.F.H. ; Hofland, Corry M. ; Westerink, Ben H.C.</creator><creatorcontrib>Kleijn, Jelle ; Cremers, Thomas I.F.H. ; Hofland, Corry M. ; Westerink, Ben H.C.</creatorcontrib><description>► CB-1 receptor modulates the effect of citalopram. ► CB-1 stimulation blocks the effect of citalopram on increasing rat prefrontal cortex 5-HT levels. ► CB-1 blockade potentiates the effect of citalopram on increasing rat prefrontal cortex 5-HT levels.
A large percentage of depressed individuals use drugs of abuse, like cannabis. This study investigates the impact of cannabis on the pharmacological effects of the antidepressant citalopram. Using microdialysis in the prefrontal cortex of rats we monitored serotonin levels before and after cannabinoid (WIN55,212-2 or rimonabant) and citalopram administration. Stimulating CB-1 decreased the effect of citalopram on increasing serotonin levels in the prefrontal cortex. Blocking CB-1 augmented this effect of citalopram. Although repeating these experiments in a chronical setting is recommended the present results might have implication for the clinical effects of citalopram.</description><identifier>ISSN: 0168-0102</identifier><identifier>EISSN: 1872-8111</identifier><identifier>DOI: 10.1016/j.neures.2011.03.004</identifier><identifier>PMID: 21420449</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Benzoxazines - pharmacology ; Cannabinoid Receptor Modulators - pharmacology ; Cannabinoids - pharmacology ; Cannabis ; CB-1 receptor ; Citalopram - pharmacology ; Drug Interactions - physiology ; Extracellular Fluid - drug effects ; Extracellular Fluid - metabolism ; In vivo microdialysis ; Male ; Morpholines - pharmacology ; Naphthalenes - pharmacology ; Piperidines - pharmacology ; Prefrontal cortex ; Prefrontal Cortex - drug effects ; Prefrontal Cortex - metabolism ; Pyrazoles - pharmacology ; Rat ; Rats ; Rats, Wistar ; Receptor, Cannabinoid, CB1 - agonists ; Receptor, Cannabinoid, CB1 - antagonists & inhibitors ; Receptor, Cannabinoid, CB1 - physiology ; Rimonabant ; Serotonin ; Serotonin - metabolism ; Serotonin Uptake Inhibitors - metabolism ; Serotonin Uptake Inhibitors - pharmacology ; SSRI</subject><ispartof>Neuroscience research, 2011-07, Vol.70 (3), p.334-337</ispartof><rights>2011 Elsevier Ireland Ltd and the Japan Neuroscience Society</rights><rights>Copyright © 2011 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-4bcde0fb48d7e17b6dfdea679ed278fa79450c19402dbf1b0e4bdba8b6f6b2ba3</citedby><cites>FETCH-LOGICAL-c417t-4bcde0fb48d7e17b6dfdea679ed278fa79450c19402dbf1b0e4bdba8b6f6b2ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neures.2011.03.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21420449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kleijn, Jelle</creatorcontrib><creatorcontrib>Cremers, Thomas I.F.H.</creatorcontrib><creatorcontrib>Hofland, Corry M.</creatorcontrib><creatorcontrib>Westerink, Ben H.C.</creatorcontrib><title>CB-1 receptors modulate the effect of the selective serotonin reuptake inhibitor, citalopram on extracellular serotonin levels in the rat prefrontal cortex</title><title>Neuroscience research</title><addtitle>Neurosci Res</addtitle><description>► CB-1 receptor modulates the effect of citalopram. ► CB-1 stimulation blocks the effect of citalopram on increasing rat prefrontal cortex 5-HT levels. ► CB-1 blockade potentiates the effect of citalopram on increasing rat prefrontal cortex 5-HT levels.
A large percentage of depressed individuals use drugs of abuse, like cannabis. This study investigates the impact of cannabis on the pharmacological effects of the antidepressant citalopram. Using microdialysis in the prefrontal cortex of rats we monitored serotonin levels before and after cannabinoid (WIN55,212-2 or rimonabant) and citalopram administration. Stimulating CB-1 decreased the effect of citalopram on increasing serotonin levels in the prefrontal cortex. Blocking CB-1 augmented this effect of citalopram. Although repeating these experiments in a chronical setting is recommended the present results might have implication for the clinical effects of citalopram.</description><subject>Animals</subject><subject>Benzoxazines - pharmacology</subject><subject>Cannabinoid Receptor Modulators - pharmacology</subject><subject>Cannabinoids - pharmacology</subject><subject>Cannabis</subject><subject>CB-1 receptor</subject><subject>Citalopram - pharmacology</subject><subject>Drug Interactions - physiology</subject><subject>Extracellular Fluid - drug effects</subject><subject>Extracellular Fluid - metabolism</subject><subject>In vivo microdialysis</subject><subject>Male</subject><subject>Morpholines - pharmacology</subject><subject>Naphthalenes - pharmacology</subject><subject>Piperidines - pharmacology</subject><subject>Prefrontal cortex</subject><subject>Prefrontal Cortex - drug effects</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Pyrazoles - pharmacology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptor, Cannabinoid, CB1 - agonists</subject><subject>Receptor, Cannabinoid, CB1 - antagonists & inhibitors</subject><subject>Receptor, Cannabinoid, CB1 - physiology</subject><subject>Rimonabant</subject><subject>Serotonin</subject><subject>Serotonin - metabolism</subject><subject>Serotonin Uptake Inhibitors - metabolism</subject><subject>Serotonin Uptake Inhibitors - pharmacology</subject><subject>SSRI</subject><issn>0168-0102</issn><issn>1872-8111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1DAUhi0EokPLG1TIOzYkHDsml02ldsRNqsSGri1fjlVPkzi1nVF5Fl4WT6egrljZlv7vP0f-CDlnUDNg7cddPeMaMdUcGKuhqQHEC7JhfcernjH2kmxKrK-AAT8hb1LaAUAziOY1OeFMcBBi2JDf26uK0YgGlxxiolOw66gy0nyLFJ1Dk2lwj6-EY3n5_eEWQw6znwu4LlndIfXzrde-VHygxmc1hiWqiYaZ4kOOyuA4ltr4jBxxj2Mq3GN3VJkuEV0Mc4GpCTHjwxl55dSY8O3TeUpuvnz-uf1WXf_4-n17eV0ZwbpcCW0sgtOitx2yTrfWWVRtN6DlXe9UN4hPYNgggFvtmAYU2mrV69a1mmvVnJL3x94lhvsVU5aTT4eV1YxhTbLvWi76tmlLUhyTJoaUyr5yiX5S8ZdkIA9W5E4erciDFQmNLFYK9u5pwKontP-gvxpK4OIYKF-Ce49RJuNxNmh9UZOlDf7_E_4AUjildw</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Kleijn, Jelle</creator><creator>Cremers, Thomas I.F.H.</creator><creator>Hofland, Corry M.</creator><creator>Westerink, Ben H.C.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20110701</creationdate><title>CB-1 receptors modulate the effect of the selective serotonin reuptake inhibitor, citalopram on extracellular serotonin levels in the rat prefrontal cortex</title><author>Kleijn, Jelle ; Cremers, Thomas I.F.H. ; Hofland, Corry M. ; Westerink, Ben H.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-4bcde0fb48d7e17b6dfdea679ed278fa79450c19402dbf1b0e4bdba8b6f6b2ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Benzoxazines - pharmacology</topic><topic>Cannabinoid Receptor Modulators - pharmacology</topic><topic>Cannabinoids - pharmacology</topic><topic>Cannabis</topic><topic>CB-1 receptor</topic><topic>Citalopram - pharmacology</topic><topic>Drug Interactions - physiology</topic><topic>Extracellular Fluid - drug effects</topic><topic>Extracellular Fluid - metabolism</topic><topic>In vivo microdialysis</topic><topic>Male</topic><topic>Morpholines - pharmacology</topic><topic>Naphthalenes - pharmacology</topic><topic>Piperidines - pharmacology</topic><topic>Prefrontal cortex</topic><topic>Prefrontal Cortex - drug effects</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Pyrazoles - pharmacology</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptor, Cannabinoid, CB1 - agonists</topic><topic>Receptor, Cannabinoid, CB1 - antagonists & inhibitors</topic><topic>Receptor, Cannabinoid, CB1 - physiology</topic><topic>Rimonabant</topic><topic>Serotonin</topic><topic>Serotonin - metabolism</topic><topic>Serotonin Uptake Inhibitors - metabolism</topic><topic>Serotonin Uptake Inhibitors - pharmacology</topic><topic>SSRI</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kleijn, Jelle</creatorcontrib><creatorcontrib>Cremers, Thomas I.F.H.</creatorcontrib><creatorcontrib>Hofland, Corry M.</creatorcontrib><creatorcontrib>Westerink, Ben H.C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kleijn, Jelle</au><au>Cremers, Thomas I.F.H.</au><au>Hofland, Corry M.</au><au>Westerink, Ben H.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CB-1 receptors modulate the effect of the selective serotonin reuptake inhibitor, citalopram on extracellular serotonin levels in the rat prefrontal cortex</atitle><jtitle>Neuroscience research</jtitle><addtitle>Neurosci Res</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>70</volume><issue>3</issue><spage>334</spage><epage>337</epage><pages>334-337</pages><issn>0168-0102</issn><eissn>1872-8111</eissn><abstract>► CB-1 receptor modulates the effect of citalopram. ► CB-1 stimulation blocks the effect of citalopram on increasing rat prefrontal cortex 5-HT levels. ► CB-1 blockade potentiates the effect of citalopram on increasing rat prefrontal cortex 5-HT levels.
A large percentage of depressed individuals use drugs of abuse, like cannabis. This study investigates the impact of cannabis on the pharmacological effects of the antidepressant citalopram. Using microdialysis in the prefrontal cortex of rats we monitored serotonin levels before and after cannabinoid (WIN55,212-2 or rimonabant) and citalopram administration. Stimulating CB-1 decreased the effect of citalopram on increasing serotonin levels in the prefrontal cortex. Blocking CB-1 augmented this effect of citalopram. Although repeating these experiments in a chronical setting is recommended the present results might have implication for the clinical effects of citalopram.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>21420449</pmid><doi>10.1016/j.neures.2011.03.004</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-0102 |
| ispartof | Neuroscience research, 2011-07, Vol.70 (3), p.334-337 |
| issn | 0168-0102 1872-8111 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_876248636 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Benzoxazines - pharmacology Cannabinoid Receptor Modulators - pharmacology Cannabinoids - pharmacology Cannabis CB-1 receptor Citalopram - pharmacology Drug Interactions - physiology Extracellular Fluid - drug effects Extracellular Fluid - metabolism In vivo microdialysis Male Morpholines - pharmacology Naphthalenes - pharmacology Piperidines - pharmacology Prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Pyrazoles - pharmacology Rat Rats Rats, Wistar Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - antagonists & inhibitors Receptor, Cannabinoid, CB1 - physiology Rimonabant Serotonin Serotonin - metabolism Serotonin Uptake Inhibitors - metabolism Serotonin Uptake Inhibitors - pharmacology SSRI |
| title | CB-1 receptors modulate the effect of the selective serotonin reuptake inhibitor, citalopram on extracellular serotonin levels in the rat prefrontal cortex |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T04%3A14%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=CB-1%20receptors%20modulate%20the%20effect%20of%20the%20selective%20serotonin%20reuptake%20inhibitor,%20citalopram%20on%20extracellular%20serotonin%20levels%20in%20the%20rat%20prefrontal%20cortex&rft.jtitle=Neuroscience%20research&rft.au=Kleijn,%20Jelle&rft.date=2011-07-01&rft.volume=70&rft.issue=3&rft.spage=334&rft.epage=337&rft.pages=334-337&rft.issn=0168-0102&rft.eissn=1872-8111&rft_id=info:doi/10.1016/j.neures.2011.03.004&rft_dat=%3Cproquest_cross%3E876248636%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=876248636&rft_id=info:pmid/21420449&rft_els_id=S0168010211000587&rfr_iscdi=true |