Alcohol Consumption, New Onset of Diabetes After Transplantation, and All-Cause Mortality in Renal Transplant Recipients
Renal transplant recipients (RTR) are often advised to refrain from alcohol because of possible interaction with their immunosuppressive medication. Although moderate alcohol consumption is associated with reduced risk of diabetes and mortality in the general population, this is unknown for RTR. The...
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| Veröffentlicht in: | Transplantation 2011-07, Vol.92 (2), p.203-209 |
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| creator | ZELLE, Dorien M AGARWAL, Pramod K PINTO RAMIREZ, Jessica L VAN DER HEIDE, Jaap J. Homan CORPELEIJN, Eva GANS, Reinold O. B NAVIS, Gerjan BAKKER, Stephan J. L |
| description | Renal transplant recipients (RTR) are often advised to refrain from alcohol because of possible interaction with their immunosuppressive medication. Although moderate alcohol consumption is associated with reduced risk of diabetes and mortality in the general population, this is unknown for RTR. Therefore, we investigated the association of alcohol consumption with new onset of diabetes after transplantation (NODAT), mortality, and graft failure in RTR.
RTR were investigated between 2001 and 2003. Alcohol consumption was assessed by self-report. Mortality and graft failure was recorded until May 2009.
Six hundred RTR were studied (age 51 ± 12 years, 55% men). Of these RTR, 48% were abstainers, 38% had light alcohol intake, 13% had moderate intake, and 1% were heavy consumers. Moderate alcohol consumption was associated with a lower risk of developing NODAT over the follow-up period than was abstention (OR = 0.36 [0.2-0.6], P = |
| doi_str_mv | 10.1097/TP.0b013e318222ca10 |
| format | Article |
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RTR were investigated between 2001 and 2003. Alcohol consumption was assessed by self-report. Mortality and graft failure was recorded until May 2009.
Six hundred RTR were studied (age 51 ± 12 years, 55% men). Of these RTR, 48% were abstainers, 38% had light alcohol intake, 13% had moderate intake, and 1% were heavy consumers. Moderate alcohol consumption was associated with a lower risk of developing NODAT over the follow-up period than was abstention (OR = 0.36 [0.2-0.6], P = <0.001). During follow-up for 7.0 years [6.2-7.5 years], 133 recipients died. In Cox regression analyses, moderate alcohol consumption was associated with lower mortality period than was abstention (hazard ratio = 0.40 [0.2-0.8], P = 0.009). Adjustment for confounders, including age and smoking, did not materially change this association. No association was found between alcohol consumption and graft failure.
Moderate alcohol consumption is associated with low prevalence of NODAT and reduced risk for mortality in RTR, in line with findings in the general population. These findings refute the common advice to refrain from alcohol in RTR.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/TP.0b013e318222ca10</identifier><identifier>PMID: 21685828</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Age ; Alcohol Drinking - adverse effects ; Alcoholic beverages ; Biological and medical sciences ; Consumers ; Diabetes mellitus ; Diabetes Mellitus - epidemiology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Ethanol ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Graft Rejection - epidemiology ; Grafts ; Humans ; Kaplan-Meier Estimate ; Kidney Transplantation - mortality ; Male ; Medical sciences ; Middle Aged ; Mortality ; Prevalence ; Regression Analysis ; Rejection ; Retrospective Studies ; Risk factors ; Smoking ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue, organ and graft immunology ; Transplantation - mortality</subject><ispartof>Transplantation, 2011-07, Vol.92 (2), p.203-209</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-efd83b6981ef11a28e8d8559270e275dc37e3863a00117110d0845dbbf292d7c3</citedby><cites>FETCH-LOGICAL-c462t-efd83b6981ef11a28e8d8559270e275dc37e3863a00117110d0845dbbf292d7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24365683$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21685828$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZELLE, Dorien M</creatorcontrib><creatorcontrib>AGARWAL, Pramod K</creatorcontrib><creatorcontrib>PINTO RAMIREZ, Jessica L</creatorcontrib><creatorcontrib>VAN DER HEIDE, Jaap J. Homan</creatorcontrib><creatorcontrib>CORPELEIJN, Eva</creatorcontrib><creatorcontrib>GANS, Reinold O. B</creatorcontrib><creatorcontrib>NAVIS, Gerjan</creatorcontrib><creatorcontrib>BAKKER, Stephan J. L</creatorcontrib><title>Alcohol Consumption, New Onset of Diabetes After Transplantation, and All-Cause Mortality in Renal Transplant Recipients</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Renal transplant recipients (RTR) are often advised to refrain from alcohol because of possible interaction with their immunosuppressive medication. Although moderate alcohol consumption is associated with reduced risk of diabetes and mortality in the general population, this is unknown for RTR. Therefore, we investigated the association of alcohol consumption with new onset of diabetes after transplantation (NODAT), mortality, and graft failure in RTR.
RTR were investigated between 2001 and 2003. Alcohol consumption was assessed by self-report. Mortality and graft failure was recorded until May 2009.
Six hundred RTR were studied (age 51 ± 12 years, 55% men). Of these RTR, 48% were abstainers, 38% had light alcohol intake, 13% had moderate intake, and 1% were heavy consumers. Moderate alcohol consumption was associated with a lower risk of developing NODAT over the follow-up period than was abstention (OR = 0.36 [0.2-0.6], P = <0.001). During follow-up for 7.0 years [6.2-7.5 years], 133 recipients died. In Cox regression analyses, moderate alcohol consumption was associated with lower mortality period than was abstention (hazard ratio = 0.40 [0.2-0.8], P = 0.009). Adjustment for confounders, including age and smoking, did not materially change this association. No association was found between alcohol consumption and graft failure.
Moderate alcohol consumption is associated with low prevalence of NODAT and reduced risk for mortality in RTR, in line with findings in the general population. These findings refute the common advice to refrain from alcohol in RTR.</description><subject>Adult</subject><subject>Age</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Alcoholic beverages</subject><subject>Biological and medical sciences</subject><subject>Consumers</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Ethanol</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Graft Rejection - epidemiology</subject><subject>Grafts</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Kidney Transplantation - mortality</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Prevalence</subject><subject>Regression Analysis</subject><subject>Rejection</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Smoking</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue, organ and graft immunology</subject><subject>Transplantation - mortality</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U1v1DAQBmALgei28AuQkC-oPZAythN79rhaPqVCK7ScI8eZCCOvE2JHtP8eo12g4sDJkvW89mhexp4JuBSwNq92N5fQgVCkBEopnRXwgK1Eo-pKA8JDtgKoRSWUMifsNKVvANAoYx6zEyk0NihxxW43wY1fx8C3Y0zLfsp-jC_5J_rBr2OizMeBv_a2o0yJb4ZMM9_NNqYp2JjtAdvY800I1dYuifjHcc42-HzHfeSfKdpwL1EunJ88xZyesEeDDYmeHs8z9uXtm932fXV1_e7DdnNVuVrLXNHQo-r0GgUNQliJhD02zVoaIGma3ilDCrWyAEIYIaAHrJu-6wa5lr1x6oydH96d5vH7Qim3e58chTIOjUtq0WhZo0JT5MV_pQBALEPpulB1oG4eU5ppaKfZ7-18V1D7q5x2d9P-W05JPT9-sHR76v9kfrdRwIsjsMnZMJS9OZ_-ulrpRqNSPwFlApgX</recordid><startdate>20110727</startdate><enddate>20110727</enddate><creator>ZELLE, Dorien M</creator><creator>AGARWAL, Pramod K</creator><creator>PINTO RAMIREZ, Jessica L</creator><creator>VAN DER HEIDE, Jaap J. Homan</creator><creator>CORPELEIJN, Eva</creator><creator>GANS, Reinold O. B</creator><creator>NAVIS, Gerjan</creator><creator>BAKKER, Stephan J. L</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20110727</creationdate><title>Alcohol Consumption, New Onset of Diabetes After Transplantation, and All-Cause Mortality in Renal Transplant Recipients</title><author>ZELLE, Dorien M ; AGARWAL, Pramod K ; PINTO RAMIREZ, Jessica L ; VAN DER HEIDE, Jaap J. Homan ; CORPELEIJN, Eva ; GANS, Reinold O. B ; NAVIS, Gerjan ; BAKKER, Stephan J. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-efd83b6981ef11a28e8d8559270e275dc37e3863a00117110d0845dbbf292d7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Age</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Alcoholic beverages</topic><topic>Biological and medical sciences</topic><topic>Consumers</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Ethanol</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Graft Rejection - epidemiology</topic><topic>Grafts</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Kidney Transplantation - mortality</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Prevalence</topic><topic>Regression Analysis</topic><topic>Rejection</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Smoking</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue, organ and graft immunology</topic><topic>Transplantation - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZELLE, Dorien M</creatorcontrib><creatorcontrib>AGARWAL, Pramod K</creatorcontrib><creatorcontrib>PINTO RAMIREZ, Jessica L</creatorcontrib><creatorcontrib>VAN DER HEIDE, Jaap J. Homan</creatorcontrib><creatorcontrib>CORPELEIJN, Eva</creatorcontrib><creatorcontrib>GANS, Reinold O. B</creatorcontrib><creatorcontrib>NAVIS, Gerjan</creatorcontrib><creatorcontrib>BAKKER, Stephan J. L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZELLE, Dorien M</au><au>AGARWAL, Pramod K</au><au>PINTO RAMIREZ, Jessica L</au><au>VAN DER HEIDE, Jaap J. Homan</au><au>CORPELEIJN, Eva</au><au>GANS, Reinold O. B</au><au>NAVIS, Gerjan</au><au>BAKKER, Stephan J. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alcohol Consumption, New Onset of Diabetes After Transplantation, and All-Cause Mortality in Renal Transplant Recipients</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2011-07-27</date><risdate>2011</risdate><volume>92</volume><issue>2</issue><spage>203</spage><epage>209</epage><pages>203-209</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Renal transplant recipients (RTR) are often advised to refrain from alcohol because of possible interaction with their immunosuppressive medication. Although moderate alcohol consumption is associated with reduced risk of diabetes and mortality in the general population, this is unknown for RTR. Therefore, we investigated the association of alcohol consumption with new onset of diabetes after transplantation (NODAT), mortality, and graft failure in RTR.
RTR were investigated between 2001 and 2003. Alcohol consumption was assessed by self-report. Mortality and graft failure was recorded until May 2009.
Six hundred RTR were studied (age 51 ± 12 years, 55% men). Of these RTR, 48% were abstainers, 38% had light alcohol intake, 13% had moderate intake, and 1% were heavy consumers. Moderate alcohol consumption was associated with a lower risk of developing NODAT over the follow-up period than was abstention (OR = 0.36 [0.2-0.6], P = <0.001). During follow-up for 7.0 years [6.2-7.5 years], 133 recipients died. In Cox regression analyses, moderate alcohol consumption was associated with lower mortality period than was abstention (hazard ratio = 0.40 [0.2-0.8], P = 0.009). Adjustment for confounders, including age and smoking, did not materially change this association. No association was found between alcohol consumption and graft failure.
Moderate alcohol consumption is associated with low prevalence of NODAT and reduced risk for mortality in RTR, in line with findings in the general population. These findings refute the common advice to refrain from alcohol in RTR.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>21685828</pmid><doi>10.1097/TP.0b013e318222ca10</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Alcohol Drinking - adverse effects Alcoholic beverages Biological and medical sciences Consumers Diabetes mellitus Diabetes Mellitus - epidemiology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Ethanol Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Rejection - epidemiology Grafts Humans Kaplan-Meier Estimate Kidney Transplantation - mortality Male Medical sciences Middle Aged Mortality Prevalence Regression Analysis Rejection Retrospective Studies Risk factors Smoking Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology Transplantation - mortality |
| title | Alcohol Consumption, New Onset of Diabetes After Transplantation, and All-Cause Mortality in Renal Transplant Recipients |
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