Bone Marrow–Derived Mesenchymal Stem Cells Transduced With Scleraxis Improve Rotator Cuff Healing in a Rat Model

Background: Rotator cuffs heal through a scar tissue interface after repair that makes them prone to failure. Scleraxis (Scx) is a basic helix-loop-helix transcription factor that is thought to direct tendon development during embryogenesis. The purpose of this study was to determine if the applicat...

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Veröffentlicht in:	The American journal of sports medicine 2011-06, Vol.39 (6), p.1282-1289
Hauptverfasser:	Gulotta, Lawrence V., Kovacevic, David, Packer, Jonathan D., Deng, Xiang Hua, Rodeo, Scott A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Animals Basic Helix-Loop-Helix Transcription Factors - genetics Biological and medical sciences Biomechanical Phenomena Bone marrow Bone Marrow Transplantation Diseases of the osteoarticular system Gene Transfer Techniques Genetic Therapy Medical sciences Mesenchymal Stem Cell Transplantation Rats Rats, Inbred Lew Rotator cuff Rotator Cuff - pathology Rotator Cuff Injuries Shoulder Skin & tissue grafts Sports medicine Stem cells Tendon Injuries - pathology Tendon Injuries - therapy
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