In vivo evidence of global and focal brain alterations in anorexia nervosa
Abstract Brain alterations are known to be associated with anorexia nervosa (AN) and tend to be distributed across brain structures, with only a few reports describing focal damage. Magnetic resonance images of 21 anorexic patients with different disease duration and 27 control subjects were acquire...
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| Veröffentlicht in: | Psychiatry research. Neuroimaging 2011-06, Vol.192 (3), p.154-159 |
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| creator | Boghi, Andrea Sterpone, Sara Sales, Stefano D'Agata, Federico Bradac, Gianni Boris Zullo, Giuseppina Munno, Donato |
| description | Abstract Brain alterations are known to be associated with anorexia nervosa (AN) and tend to be distributed across brain structures, with only a few reports describing focal damage. Magnetic resonance images of 21 anorexic patients with different disease duration and 27 control subjects were acquired and compared using voxel-based morphometry (VBM). Patients had a significant reduction of total white matter (WM) volume and focal gray matter (GM) atrophy in cerebellum, hypothalamus, caudate nucleus and frontal, parietal and temporal areas. The cerebellum was more affected in patients with longer disease duration, whereas the hypothalamic alterations were more pronounced in patients with shorter food restriction. A correlation with body mass index (BMI) and GM was found in the hypothalamus. Our data demonstrate a diffuse reduction of WM together with focal areas of GM atrophy in AN. The finding of a hypothalamic focal atrophy points to hormonal dysfunction and opens the possibility for a central dysregulation of homeostasis. The involvement of temporoparietal areas could account for body image distortion. Finally, the cerebellar GM atrophy confirms previous findings and seems to be a late consequence of AN that could play a role in the chronic phase of the disease. |
| doi_str_mv | 10.1016/j.pscychresns.2010.12.008 |
| format | Article |
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Magnetic resonance images of 21 anorexic patients with different disease duration and 27 control subjects were acquired and compared using voxel-based morphometry (VBM). Patients had a significant reduction of total white matter (WM) volume and focal gray matter (GM) atrophy in cerebellum, hypothalamus, caudate nucleus and frontal, parietal and temporal areas. The cerebellum was more affected in patients with longer disease duration, whereas the hypothalamic alterations were more pronounced in patients with shorter food restriction. A correlation with body mass index (BMI) and GM was found in the hypothalamus. Our data demonstrate a diffuse reduction of WM together with focal areas of GM atrophy in AN. The finding of a hypothalamic focal atrophy points to hormonal dysfunction and opens the possibility for a central dysregulation of homeostasis. The involvement of temporoparietal areas could account for body image distortion. Finally, the cerebellar GM atrophy confirms previous findings and seems to be a late consequence of AN that could play a role in the chronic phase of the disease.</description><identifier>ISSN: 0925-4927</identifier><identifier>EISSN: 1872-7506</identifier><identifier>DOI: 10.1016/j.pscychresns.2010.12.008</identifier><identifier>PMID: 21546219</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Adult and adolescent clinical studies ; Anorexia nervosa ; Anorexia Nervosa - pathology ; Biological and medical sciences ; Brain - pathology ; Brain - physiopathology ; Brain Mapping ; Caudate nucleus ; Cerebellum ; Eating behavior disorders ; Eating disorder ; Female ; Humans ; Hypothalamus ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Medical sciences ; Middle Aged ; Neuroimaging ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c559t-5bc5f2a54fb6004ae047456f241062ffc94bdacb81bb3ba55c74d07929663ca3</citedby><cites>FETCH-LOGICAL-c559t-5bc5f2a54fb6004ae047456f241062ffc94bdacb81bb3ba55c74d07929663ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0925492710004300$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24211652$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21546219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boghi, Andrea</creatorcontrib><creatorcontrib>Sterpone, Sara</creatorcontrib><creatorcontrib>Sales, Stefano</creatorcontrib><creatorcontrib>D'Agata, Federico</creatorcontrib><creatorcontrib>Bradac, Gianni Boris</creatorcontrib><creatorcontrib>Zullo, Giuseppina</creatorcontrib><creatorcontrib>Munno, Donato</creatorcontrib><title>In vivo evidence of global and focal brain alterations in anorexia nervosa</title><title>Psychiatry research. Neuroimaging</title><addtitle>Psychiatry Res</addtitle><description>Abstract Brain alterations are known to be associated with anorexia nervosa (AN) and tend to be distributed across brain structures, with only a few reports describing focal damage. Magnetic resonance images of 21 anorexic patients with different disease duration and 27 control subjects were acquired and compared using voxel-based morphometry (VBM). Patients had a significant reduction of total white matter (WM) volume and focal gray matter (GM) atrophy in cerebellum, hypothalamus, caudate nucleus and frontal, parietal and temporal areas. The cerebellum was more affected in patients with longer disease duration, whereas the hypothalamic alterations were more pronounced in patients with shorter food restriction. A correlation with body mass index (BMI) and GM was found in the hypothalamus. Our data demonstrate a diffuse reduction of WM together with focal areas of GM atrophy in AN. The finding of a hypothalamic focal atrophy points to hormonal dysfunction and opens the possibility for a central dysregulation of homeostasis. The involvement of temporoparietal areas could account for body image distortion. Finally, the cerebellar GM atrophy confirms previous findings and seems to be a late consequence of AN that could play a role in the chronic phase of the disease.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Anorexia nervosa</subject><subject>Anorexia Nervosa - pathology</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Brain Mapping</subject><subject>Caudate nucleus</subject><subject>Cerebellum</subject><subject>Eating behavior disorders</subject><subject>Eating disorder</subject><subject>Female</subject><subject>Humans</subject><subject>Hypothalamus</subject><subject>Image Processing, Computer-Assisted</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuroimaging</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. 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Psychiatry</subject><subject>Radiology</subject><subject>Voxel-based morphometry</subject><subject>Young Adult</subject><issn>0925-4927</issn><issn>1872-7506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkuP0zAQgC0EYsvCX0DhgDiljB0_kgsSqngsWokDe7dsZwwuqV3sNqL_HkctD3GBkx_6Zsb-Zgh5RmFNgcqX2_W-uJP7krHEsmaw3LM1QH-PrGivWKsEyPtkBQMTLR-YuiKPStkCsK6X3UNyxajgktFhRT7cxGYOc2pwDiNGh03yzecpWTM1Jo6NT67ubDYhNmY6YDaHkGJplmNMGb8H00TMcyrmMXngzVTwyWW9Jndv39xt3re3H9_dbF7ftk6I4dAK64RnRnBvJQA3CFxxIT3jFCTz3g3cjsbZnlrbWSOEU3wENbBBys6Z7pq8OKfd5_TtiOWgd6E4nCYTMR2L7pVkXKn60X-SUikmhIJKDmfS5VRKRq_3OexMPmkKelGut_oP5XpRrinTVXmNfXqpcrQ7HH9F_nRcgecXwJQq02cTXSi_Oc4olYJVbnPmsMqbA2ZdXFhaMoaM7qDHFP7rOa_-yuKmEEMt_BVPWLbpmGPtjqa61AD9aZmRZUQo1GZ0AN0PggS5_A</recordid><startdate>20110630</startdate><enddate>20110630</enddate><creator>Boghi, Andrea</creator><creator>Sterpone, Sara</creator><creator>Sales, Stefano</creator><creator>D'Agata, Federico</creator><creator>Bradac, Gianni Boris</creator><creator>Zullo, Giuseppina</creator><creator>Munno, Donato</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20110630</creationdate><title>In vivo evidence of global and focal brain alterations in anorexia nervosa</title><author>Boghi, Andrea ; Sterpone, Sara ; Sales, Stefano ; D'Agata, Federico ; Bradac, Gianni Boris ; Zullo, Giuseppina ; Munno, Donato</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c559t-5bc5f2a54fb6004ae047456f241062ffc94bdacb81bb3ba55c74d07929663ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Anorexia nervosa</topic><topic>Anorexia Nervosa - pathology</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Brain Mapping</topic><topic>Caudate nucleus</topic><topic>Cerebellum</topic><topic>Eating behavior disorders</topic><topic>Eating disorder</topic><topic>Female</topic><topic>Humans</topic><topic>Hypothalamus</topic><topic>Image Processing, Computer-Assisted</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuroimaging</topic><topic>Psychiatry</topic><topic>Psychology. 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| subjects | Adult Adult and adolescent clinical studies Anorexia nervosa Anorexia Nervosa - pathology Biological and medical sciences Brain - pathology Brain - physiopathology Brain Mapping Caudate nucleus Cerebellum Eating behavior disorders Eating disorder Female Humans Hypothalamus Image Processing, Computer-Assisted Magnetic Resonance Imaging Medical sciences Middle Aged Neuroimaging Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radiology Voxel-based morphometry Young Adult |
| title | In vivo evidence of global and focal brain alterations in anorexia nervosa |
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