Azathioprine-associated severe myelosuppression: indication of routine determination of thiopurine S-methyltransferase variant?

Myelotoxicity is a well-known adverse effect of azathioprine, leading mainly to leukopenia. Other azathioprine associated hematological adverse effects are uncommon. We report a 49-year-old woman with rheumatoid arthritis and acquired hemophilia, who presented a severe myelosuppression occurring 3 w...

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Veröffentlicht in:	La revue de medecine interne 2011-06, Vol.32 (6), p.373-376
Hauptverfasser:	Ngo, S, Sauvetre, G, Vittecoq, O, Lévesque, H, Marie, I
Format:	Artikel
Sprache:	fre
Schlagworte:	Antirheumatic Agents - adverse effects Azathioprine - adverse effects Female Humans Methyltransferases - blood Methyltransferases - genetics Middle Aged Mutation Pancytopenia - chemically induced
Online-Zugang:	Volltext
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