Onconase mediated NFKβ downregulation in malignant pleural mesothelioma

Treatment of malignant pleural mesothelioma (MPM) with Ranpirnase (Onconase) results in disruption of protein translation and cell apoptosis. We hypothesize that Onconase exerts an effect via downregulation of nuclear factor kappa B (NFKβ) by specific microRNAs (miRNAs) and that interference of this...

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Veröffentlicht in:	Oncogene 2011-06, Vol.30 (24), p.2767-2777
Hauptverfasser:	Goparaju, C M, Blasberg, J D, Volinia, S, Palatini, J, Ivanov, S, Donington, J S, Croce, C, Carbone, M, Yang, H, Pass, H I
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/200 631/337/384/331 631/67/1059 692/699/67/1641 Antineoplastic Agents - pharmacology Antitumor activity Apoptosis ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Bcl-x protein Biological and medical sciences Cell Biology Cell growth Cell Line, Tumor Cell lines Cell physiology Cell proliferation Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chemotherapy Development and progression Down-Regulation Drug resistance Fundamental and applied biological sciences. Psychology Gene expression Genetic aspects Human Genetics Humans Internal Medicine Medical sciences Medicine Medicine & Public Health Mesothelioma Mesothelioma - drug therapy Mesothelioma - enzymology MicroRNA MicroRNAs MicroRNAs - analysis MicroRNAs - physiology miRNA Molecular and cellular biology NF-kappa B - antagonists & inhibitors NF-kappa B - genetics NF-kappa B - physiology Oncology original-article Physiological aspects Pleural Neoplasms - drug therapy Pleural Neoplasms - enzymology Pneumology Reverse transcription Ribonucleases - pharmacology Transfection Tumors of the respiratory system and mediastinum Western blotting
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