Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-β cytostatic program and blocks the antiproliferative effect of TGF-β

The antiproliferative activity of transforming growth factor-β (TGF-β) is essential for maintaining normal tissue homeostasis and is lost in many types of tumors. Gene responses that are central to the TGF-β cytostatic program include activation of the cyclin-dependent kinase inhibitors, p15 Ink4B a...

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Veröffentlicht in:	Oncogene 2011-06, Vol.30 (24), p.2718-2729
Hauptverfasser:	Trinh, B Q, Barengo, N, Naora, H
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/68 631/45/127/1219 Apoptosis Biological and medical sciences Bone Morphogenetic Proteins - physiology Breast c-Myc protein Cell Biology Cell Line, Tumor Cell physiology Cell proliferation Cell Proliferation - drug effects Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cyclin-dependent kinase Cyclin-Dependent Kinase Inhibitor p15 - genetics Cyclin-dependent kinase inhibitor p21 Cyclin-dependent kinases Fundamental and applied biological sciences. Psychology Genetic transcription Homeobox Homeodomain Proteins - physiology Homeostasis Human Genetics Humans Internal Medicine Kinases Medicine Medicine & Public Health Molecular and cellular biology Molecular genetics Myc protein Oncology original-article Ovarian cancer Physiological aspects Promoter Regions, Genetic Prostate Smad protein Smad Proteins, Receptor-Regulated - metabolism Smad2 protein Smad3 protein Smad4 protein Smad4 Protein - physiology Sp1 protein Sp1 Transcription Factor - metabolism Transcription factors Transcription Factors - physiology Transcription, Genetic Transcription. Transcription factor. Splicing. Rna processing Transforming Growth Factor beta - antagonists & inhibitors Transforming Growth Factor beta - metabolism Transforming growth factor-b Transforming growth factors Tumors
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