Kinetic Analysis of [ C]MP4A Using a High-Radioactivity Brain Region That Represents an Integrated Input Function for Measurement of Cerebral Acetylcholinesterase Activity Without Arterial Blood Sampling

N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) is an acetylcholine analog. It has been used successfully for the quantitative measurement of acetylcholinesterase (AChE) activity in the human brain with positron emission tomography (PET). [11C]MP4A is specifically hydrolyzed by AChE in the brain to...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2001-11, Vol.21 (11), p.1354-1366
Hauptverfasser:	Nagatsuka, Shin-Ichiro, Fukushi, Kiyoshi, Shinotoh, Hitoshi, Namba, Hiroki, Iyo, Masaomi, Tanaka, Noriko, Aotsuka, Akiyo, Ota, Tsuneyoshi, Tanada, Shuji, Irie, Toshiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates Acetylcholinesterase - metabolism Adult Aged Alzheimer Disease - diagnostic imaging Alzheimer Disease - metabolism Biological and medical sciences Blood Specimen Collection Brain - diagnostic imaging Brain - enzymology Carbon Radioisotopes Computer Simulation Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Humans Kinetics Least-Squares Analysis Medical sciences Middle Aged Models, Biological Neurology Piperidines Tomography, Emission-Computed - methods
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