Presynaptic nitric oxide/cGMP facilitates glutamate release via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus

In hippocampal neurons, synaptic transmission is affected by a variety of modulators, including nitric oxide (NO), which was proposed as a retrograde messenger as long as two decades ago. NO signals via two NO‐sensitive guanylyl cyclases (NO‐GCs) (NO‐GC1 and NO‐GC2) and the subsequent increase in cG...

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Veröffentlicht in:	The European journal of neuroscience 2011-05, Vol.33 (9), p.1611-1621
Hauptverfasser:	Neitz, Angela, Mergia, Evanthia, Eysel, Ulf T., Koesling, Doris, Mittmann, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	acute hippocampal slices Animals Benzazepines - metabolism Cyclic GMP Cyclic GMP - analogs & derivatives Cyclic GMP - metabolism Cyclic Nucleotide-Gated Cation Channels - antagonists & inhibitors Cyclic Nucleotide-Gated Cation Channels - genetics Cyclic Nucleotide-Gated Cation Channels - metabolism Glutamatergic transmission Glutamic acid Glutamic Acid - metabolism Guanylate cyclase Guanylate Cyclase - genetics Guanylate Cyclase - metabolism guanylyl cyclase Hippocampus Hippocampus - cytology Hippocampus - metabolism Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels ion channels (cyclic nucleotide-gated) knockout mice Long-term potentiation Mice Mice, Inbred C57BL Mice, Knockout Nervous system Neuromodulation Neurons Nitric oxide Nitric Oxide - metabolism Nitric-oxide synthase NO synthase Potassium Channels - genetics Potassium Channels - metabolism Presynaptic Terminals - metabolism Protein Isoforms - genetics Protein Isoforms - metabolism Pyrimidines - metabolism Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Signal transduction Signal Transduction - physiology Soluble Guanylyl Cyclase Synaptic transmission Synaptic Transmission - physiology
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