Changes in lower extremity muscle function after 56 days of bed rest

Preservation of muscle function, known to decline in microgravity and simulation (bed rest), is important for successful spaceflight missions. Hence, there is great interest in developing interventions to prevent muscle-function loss. In this study, 20 males underwent 56 days of bed rest. Ten volunt...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of applied physiology (1985) 2011-07, Vol.111 (1), p.87-94
Hauptverfasser: BUEHRING, B, BELAVY, D. L, MICHAELIS, I, GAST, U, FELSENBERG, D, RITTWEGER, J
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 94
container_issue 1
container_start_page 87
container_title Journal of applied physiology (1985)
container_volume 111
creator BUEHRING, B
BELAVY, D. L
MICHAELIS, I
GAST, U
FELSENBERG, D
RITTWEGER, J
description Preservation of muscle function, known to decline in microgravity and simulation (bed rest), is important for successful spaceflight missions. Hence, there is great interest in developing interventions to prevent muscle-function loss. In this study, 20 males underwent 56 days of bed rest. Ten volunteers were randomized to do resistive vibration exercise (RVE). The other 10 served as controls. RVE consisted of muscle contractions against resistance and concurrent whole-body vibration. Main outcome parameters were maximal isometric plantar-flexion force (IPFF), electromyography (EMG)/force ratio, as well as jumping power and height. Measurements were obtained before and after bed rest, including a morning and evening assessment on the first day of recovery from bed rest. IPFF (-17.1%), jumping peak power (-24.1%), and height (-28.5%) declined (P < 0.05) in the control group. There was a trend to EMG/force ratio decrease (-20%; P = 0.051). RVE preserved IPFF and mitigated the decline of countermovement jump performance (peak power -12.2%; height -14.2%). In both groups, IPFF was reduced between the two measurements of the first day of reambulation. This study indicates that bed rest and countermeasure exercises differentially affect the various functions of skeletal muscle. Moreover, the time course during recovery needs to be considered more thoroughly in future studies, as IPFF declined not only with bed rest but also within the first day of reambulation. RVE was effective in maintaining IPFF but only mitigated the decline in jumping performance. More research is needed to develop countermeasures that maintain muscle strength as well as other muscle functions including power.
doi_str_mv 10.1152/japplphysiol.01294.2010
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_876243595</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2401763241</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-2e6d630fa67cd09f3504eadbf1c3aa4849adcc2af0e377b8c50bfd407b703a853</originalsourceid><addsrcrecordid>eNpdkEtP3DAURi3UCqbAX2itSlVXGa7fyRJNW6iE1E1ZRzeODRklcbATtfPv64Hhoa7u4jv3dQj5xGDNmOIXW5ymfrrfpS70a2C8kmsODI7IKqe8YBrYO7IqjYLCqNKckA8pbQGYlIodkxOeKaO1XJFvm3sc71yi3Uj78MdF6v7O0Q3dvKPDkmzvqF9GO3dhpOjnnCtNW9wlGjxtXEujS_MZee-xT-78UE_J7Y_vvzfXxc2vq5-by5vCSlbOBXe61QI8amNbqLxQIB22jWdWIMpSVthay9GDE8Y0pVXQ-FaCaQwILJU4JV-f5k4xPCx5cT10ybq-x9GFJdWl0VwKVe3Jz_-R27DEMR-XIVNWzADLkHmCbAwpRefrKXYDxl3NoN5rrt9qrh8113vNufPjYfzSDK596Xv2moEvBwCTxd5HHG2XXjkp8vNai3-g5Ikd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>877891701</pqid></control><display><type>article</type><title>Changes in lower extremity muscle function after 56 days of bed rest</title><source>MEDLINE</source><source>American Physiological Society</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>BUEHRING, B ; BELAVY, D. L ; MICHAELIS, I ; GAST, U ; FELSENBERG, D ; RITTWEGER, J</creator><creatorcontrib>BUEHRING, B ; BELAVY, D. L ; MICHAELIS, I ; GAST, U ; FELSENBERG, D ; RITTWEGER, J</creatorcontrib><description>Preservation of muscle function, known to decline in microgravity and simulation (bed rest), is important for successful spaceflight missions. Hence, there is great interest in developing interventions to prevent muscle-function loss. In this study, 20 males underwent 56 days of bed rest. Ten volunteers were randomized to do resistive vibration exercise (RVE). The other 10 served as controls. RVE consisted of muscle contractions against resistance and concurrent whole-body vibration. Main outcome parameters were maximal isometric plantar-flexion force (IPFF), electromyography (EMG)/force ratio, as well as jumping power and height. Measurements were obtained before and after bed rest, including a morning and evening assessment on the first day of recovery from bed rest. IPFF (-17.1%), jumping peak power (-24.1%), and height (-28.5%) declined (P &lt; 0.05) in the control group. There was a trend to EMG/force ratio decrease (-20%; P = 0.051). RVE preserved IPFF and mitigated the decline of countermovement jump performance (peak power -12.2%; height -14.2%). In both groups, IPFF was reduced between the two measurements of the first day of reambulation. This study indicates that bed rest and countermeasure exercises differentially affect the various functions of skeletal muscle. Moreover, the time course during recovery needs to be considered more thoroughly in future studies, as IPFF declined not only with bed rest but also within the first day of reambulation. RVE was effective in maintaining IPFF but only mitigated the decline in jumping performance. More research is needed to develop countermeasures that maintain muscle strength as well as other muscle functions including power.</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.01294.2010</identifier><identifier>PMID: 21527664</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: American Physiological Society</publisher><subject>Adult ; Analysis of Variance ; Bed Rest - adverse effects ; Biological and medical sciences ; Biomechanical Phenomena ; Electromyography ; Exercise ; Fundamental and applied biological sciences. Psychology ; Germany ; Human performance ; Humans ; Isometric Contraction ; Linear Models ; Lower Extremity ; Male ; Muscle Strength ; Muscle Weakness - etiology ; Muscle Weakness - physiopathology ; Muscle Weakness - prevention &amp; control ; Muscle, Skeletal - physiopathology ; Musculoskeletal system ; Physiology ; Recovery of Function ; Time Factors ; Treatment Outcome ; Vibration - therapeutic use ; Weightlessness Countermeasures ; Weightlessness Simulation - adverse effects</subject><ispartof>Journal of applied physiology (1985), 2011-07, Vol.111 (1), p.87-94</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright American Physiological Society Jul 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-2e6d630fa67cd09f3504eadbf1c3aa4849adcc2af0e377b8c50bfd407b703a853</citedby><cites>FETCH-LOGICAL-c418t-2e6d630fa67cd09f3504eadbf1c3aa4849adcc2af0e377b8c50bfd407b703a853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=24335066$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21527664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BUEHRING, B</creatorcontrib><creatorcontrib>BELAVY, D. L</creatorcontrib><creatorcontrib>MICHAELIS, I</creatorcontrib><creatorcontrib>GAST, U</creatorcontrib><creatorcontrib>FELSENBERG, D</creatorcontrib><creatorcontrib>RITTWEGER, J</creatorcontrib><title>Changes in lower extremity muscle function after 56 days of bed rest</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Preservation of muscle function, known to decline in microgravity and simulation (bed rest), is important for successful spaceflight missions. Hence, there is great interest in developing interventions to prevent muscle-function loss. In this study, 20 males underwent 56 days of bed rest. Ten volunteers were randomized to do resistive vibration exercise (RVE). The other 10 served as controls. RVE consisted of muscle contractions against resistance and concurrent whole-body vibration. Main outcome parameters were maximal isometric plantar-flexion force (IPFF), electromyography (EMG)/force ratio, as well as jumping power and height. Measurements were obtained before and after bed rest, including a morning and evening assessment on the first day of recovery from bed rest. IPFF (-17.1%), jumping peak power (-24.1%), and height (-28.5%) declined (P &lt; 0.05) in the control group. There was a trend to EMG/force ratio decrease (-20%; P = 0.051). RVE preserved IPFF and mitigated the decline of countermovement jump performance (peak power -12.2%; height -14.2%). In both groups, IPFF was reduced between the two measurements of the first day of reambulation. This study indicates that bed rest and countermeasure exercises differentially affect the various functions of skeletal muscle. Moreover, the time course during recovery needs to be considered more thoroughly in future studies, as IPFF declined not only with bed rest but also within the first day of reambulation. RVE was effective in maintaining IPFF but only mitigated the decline in jumping performance. More research is needed to develop countermeasures that maintain muscle strength as well as other muscle functions including power.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Bed Rest - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Biomechanical Phenomena</subject><subject>Electromyography</subject><subject>Exercise</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Germany</subject><subject>Human performance</subject><subject>Humans</subject><subject>Isometric Contraction</subject><subject>Linear Models</subject><subject>Lower Extremity</subject><subject>Male</subject><subject>Muscle Strength</subject><subject>Muscle Weakness - etiology</subject><subject>Muscle Weakness - physiopathology</subject><subject>Muscle Weakness - prevention &amp; control</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Musculoskeletal system</subject><subject>Physiology</subject><subject>Recovery of Function</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Vibration - therapeutic use</subject><subject>Weightlessness Countermeasures</subject><subject>Weightlessness Simulation - adverse effects</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtP3DAURi3UCqbAX2itSlVXGa7fyRJNW6iE1E1ZRzeODRklcbATtfPv64Hhoa7u4jv3dQj5xGDNmOIXW5ymfrrfpS70a2C8kmsODI7IKqe8YBrYO7IqjYLCqNKckA8pbQGYlIodkxOeKaO1XJFvm3sc71yi3Uj78MdF6v7O0Q3dvKPDkmzvqF9GO3dhpOjnnCtNW9wlGjxtXEujS_MZee-xT-78UE_J7Y_vvzfXxc2vq5-by5vCSlbOBXe61QI8amNbqLxQIB22jWdWIMpSVthay9GDE8Y0pVXQ-FaCaQwILJU4JV-f5k4xPCx5cT10ybq-x9GFJdWl0VwKVe3Jz_-R27DEMR-XIVNWzADLkHmCbAwpRefrKXYDxl3NoN5rrt9qrh8113vNufPjYfzSDK596Xv2moEvBwCTxd5HHG2XXjkp8vNai3-g5Ikd</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>BUEHRING, B</creator><creator>BELAVY, D. L</creator><creator>MICHAELIS, I</creator><creator>GAST, U</creator><creator>FELSENBERG, D</creator><creator>RITTWEGER, J</creator><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20110701</creationdate><title>Changes in lower extremity muscle function after 56 days of bed rest</title><author>BUEHRING, B ; BELAVY, D. L ; MICHAELIS, I ; GAST, U ; FELSENBERG, D ; RITTWEGER, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-2e6d630fa67cd09f3504eadbf1c3aa4849adcc2af0e377b8c50bfd407b703a853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Bed Rest - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Biomechanical Phenomena</topic><topic>Electromyography</topic><topic>Exercise</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Germany</topic><topic>Human performance</topic><topic>Humans</topic><topic>Isometric Contraction</topic><topic>Linear Models</topic><topic>Lower Extremity</topic><topic>Male</topic><topic>Muscle Strength</topic><topic>Muscle Weakness - etiology</topic><topic>Muscle Weakness - physiopathology</topic><topic>Muscle Weakness - prevention &amp; control</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Musculoskeletal system</topic><topic>Physiology</topic><topic>Recovery of Function</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Vibration - therapeutic use</topic><topic>Weightlessness Countermeasures</topic><topic>Weightlessness Simulation - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BUEHRING, B</creatorcontrib><creatorcontrib>BELAVY, D. L</creatorcontrib><creatorcontrib>MICHAELIS, I</creatorcontrib><creatorcontrib>GAST, U</creatorcontrib><creatorcontrib>FELSENBERG, D</creatorcontrib><creatorcontrib>RITTWEGER, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BUEHRING, B</au><au>BELAVY, D. L</au><au>MICHAELIS, I</au><au>GAST, U</au><au>FELSENBERG, D</au><au>RITTWEGER, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in lower extremity muscle function after 56 days of bed rest</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>111</volume><issue>1</issue><spage>87</spage><epage>94</epage><pages>87-94</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Preservation of muscle function, known to decline in microgravity and simulation (bed rest), is important for successful spaceflight missions. Hence, there is great interest in developing interventions to prevent muscle-function loss. In this study, 20 males underwent 56 days of bed rest. Ten volunteers were randomized to do resistive vibration exercise (RVE). The other 10 served as controls. RVE consisted of muscle contractions against resistance and concurrent whole-body vibration. Main outcome parameters were maximal isometric plantar-flexion force (IPFF), electromyography (EMG)/force ratio, as well as jumping power and height. Measurements were obtained before and after bed rest, including a morning and evening assessment on the first day of recovery from bed rest. IPFF (-17.1%), jumping peak power (-24.1%), and height (-28.5%) declined (P &lt; 0.05) in the control group. There was a trend to EMG/force ratio decrease (-20%; P = 0.051). RVE preserved IPFF and mitigated the decline of countermovement jump performance (peak power -12.2%; height -14.2%). In both groups, IPFF was reduced between the two measurements of the first day of reambulation. This study indicates that bed rest and countermeasure exercises differentially affect the various functions of skeletal muscle. Moreover, the time course during recovery needs to be considered more thoroughly in future studies, as IPFF declined not only with bed rest but also within the first day of reambulation. RVE was effective in maintaining IPFF but only mitigated the decline in jumping performance. More research is needed to develop countermeasures that maintain muscle strength as well as other muscle functions including power.</abstract><cop>Bethesda, MD</cop><pub>American Physiological Society</pub><pmid>21527664</pmid><doi>10.1152/japplphysiol.01294.2010</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 8750-7587
ispartof Journal of applied physiology (1985), 2011-07, Vol.111 (1), p.87-94
issn 8750-7587
1522-1601
language eng
recordid cdi_proquest_miscellaneous_876243595
source MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection
subjects Adult
Analysis of Variance
Bed Rest - adverse effects
Biological and medical sciences
Biomechanical Phenomena
Electromyography
Exercise
Fundamental and applied biological sciences. Psychology
Germany
Human performance
Humans
Isometric Contraction
Linear Models
Lower Extremity
Male
Muscle Strength
Muscle Weakness - etiology
Muscle Weakness - physiopathology
Muscle Weakness - prevention & control
Muscle, Skeletal - physiopathology
Musculoskeletal system
Physiology
Recovery of Function
Time Factors
Treatment Outcome
Vibration - therapeutic use
Weightlessness Countermeasures
Weightlessness Simulation - adverse effects
title Changes in lower extremity muscle function after 56 days of bed rest
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T09%3A00%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Changes%20in%20lower%20extremity%20muscle%20function%20after%2056%20days%20of%20bed%20rest&rft.jtitle=Journal%20of%20applied%20physiology%20(1985)&rft.au=BUEHRING,%20B&rft.date=2011-07-01&rft.volume=111&rft.issue=1&rft.spage=87&rft.epage=94&rft.pages=87-94&rft.issn=8750-7587&rft.eissn=1522-1601&rft.coden=JAPHEV&rft_id=info:doi/10.1152/japplphysiol.01294.2010&rft_dat=%3Cproquest_cross%3E2401763241%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=877891701&rft_id=info:pmid/21527664&rfr_iscdi=true