Antibody forming cells and plasmablasts in peripheral blood in CVID patients after vaccination

Abstract Common variable immunodeficiency (CVID), the most frequent primary antibody disorder, is characterized by hypogammaglobulinaemia and impaired antibody production. Poor vaccination response is essential for the diagnosis of CVID. Their under laying defects remain to be elucidated. Routine de...

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Veröffentlicht in:	Vaccine 2011-05, Vol.29 (24), p.4142-4150
Hauptverfasser:	Chovancova, Zita, Vlkova, Marcela, Litzman, Jiri, Lokaj, Jindrich, Thon, Vojtech
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Allergy and Immunology antibodies Antibodies, Bacterial - biosynthesis antibody formation Antigens Applied microbiology B-lymphocytes B-Lymphocytes - cytology B-Lymphocytes - immunology Bacteriology Biological and medical sciences blood flow blood serum Cell Differentiation Classification Common Variable Immunodeficiency - diagnosis Common Variable Immunodeficiency - immunology CVID Defects ELISPOT Enzyme-Linked Immunospot Assay Female Flow Cytometry Fundamental and applied biological sciences. Psychology Humans Immune system Immunization immunoglobulin A immunoglobulin G immunoglobulin M immunosuppression (physiological) Lymphocyte Subsets - immunology Male Males Microbiology Middle Aged Miscellaneous Mortality Patients Pneumococcal vaccine Pneumococcal Vaccines - administration & dosage Pneumococcal Vaccines - immunology Proteins Streptococcus pneumoniae Subpopulations Tetanus Tetanus toxoid Tetanus Toxoid - administration & dosage Tetanus Toxoid - immunology vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) volunteers
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