model of BmK CT in inhibiting glioma cell migration via matrix metalloproteinase-2 from experimental and molecular dynamics simulation study

The significance of BmK CT, a key chlorotoxin-like peptide isolated from the scorpion venom of Buthus martensii Karsch, is a novel blocker of the chloride ion channel and matrix metalloproteinase-2 (MMP-2). Site-directed mutagenesis of BmK CT, wound healing assay, gelatin zymography assay and comput...

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Veröffentlicht in:	Biotechnology letters 2011-07, Vol.33 (7), p.1309-1317
Hauptverfasser:	Fu, Yue-Jun, An, Na, Chan, Kok-Gan, Wu, Yan-Bo, Zheng, Shu-Hua, Liang, Ai-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	active sites Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Applied Microbiology Assaying Biochemistry Biological and medical sciences Biomedical and Life Sciences Biotechnology Brain cancer Buthus martensii Catalysis Catalysts Cell adhesion & migration cell movement Cell Movement - drug effects Chlorides Computer simulation Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Fundamental and applied biological sciences. Psychology gelatin gelatinase A Inhibitors ion channels Life Sciences Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase Inhibitors Microbiology Migration Models, Molecular Molecular biology molecular dynamics Molecular Dynamics Simulation Mutagenesis, Site-Directed Original Research Paper Peptides Protein Structure, Tertiary Scorpion Venoms - chemistry Scorpion Venoms - genetics Scorpion Venoms - metabolism site-directed mutagenesis tissue repair Venom Wound Healing - drug effects
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