Hydrogen-Bond-Directed Giant Unilamellar Vesicles of Guanosine Derivative: Preparation, Properties, and Fusion
By mixing a small volume of THF containing guanosine derivative 1 and tetraethylenegrycol dodecyl ether (TEGDE) with water and subsequently removing TEGDE by gel permeation chromatography, micrometer-sized giant unilamellar vesicles (GUV) of 1 were successfully prepared. The vesicle membrane was a 2...
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| Veröffentlicht in: | Langmuir 2011-07, Vol.27 (14), p.8653-8658 |
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| creator | Sawayama, Jun Sakaino, Hirotoshi Kabashima, Shin-ichiro Yoshikawa, Isao Araki, Koji |
| description | By mixing a small volume of THF containing guanosine derivative 1 and tetraethylenegrycol dodecyl ether (TEGDE) with water and subsequently removing TEGDE by gel permeation chromatography, micrometer-sized giant unilamellar vesicles (GUV) of 1 were successfully prepared. The vesicle membrane was a 2-D sheet assembly of thickness 2.5 nm, composed of a 2-D inter-guanine hydrogen-bond network. The GUV dispersion showed high stability because of a large negative zeta potential, which allowed repeated sedimentation and redispersion by centrifugation and subsequent gentle agitation. TEGDE-triggered fusion of GUVs took place within 350 ms, which proceeded by fusion of the vesicle membranes in contact. These unique static and dynamic properties of the GUV membrane assembled by the 2-D hydrogen-bond network are discussed. |
| doi_str_mv | 10.1021/la201350r |
| format | Article |
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The vesicle membrane was a 2-D sheet assembly of thickness 2.5 nm, composed of a 2-D inter-guanine hydrogen-bond network. The GUV dispersion showed high stability because of a large negative zeta potential, which allowed repeated sedimentation and redispersion by centrifugation and subsequent gentle agitation. TEGDE-triggered fusion of GUVs took place within 350 ms, which proceeded by fusion of the vesicle membranes in contact. 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| subjects | Chemistry Colloidal state and disperse state Colloids: Surfactants and Self-Assembly, Dispersions, Emulsions, Foams Exact sciences and technology General and physical chemistry Guanosine - analogs & derivatives Hydrogen Bonding Membranes Polyethylene Glycols - chemistry Unilamellar Liposomes - chemistry Water - chemistry |
| title | Hydrogen-Bond-Directed Giant Unilamellar Vesicles of Guanosine Derivative: Preparation, Properties, and Fusion |
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