Primary central nervous system extranodal NK/T-cell lymphoma, nasal type: case report and review of the literature
Primary central nervous system (CNS) extranodal NK/T-cell lymphoma, nasal type (NKTCL), is an extremely rare tumor. To the best of our knowledge, only four cases have been described previously. Here, we report a case of primary CNS NKTCL in a 25-year-old immunocompetent Chinese male. The patient pre...
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| Veröffentlicht in: | Journal of neuro-oncology 2011-06, Vol.103 (2), p.387-391 |
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| creator | Guan, Hong Huang, Yuhua Wen, Wen Xu, Meiquan Zan, Qin Zhang, Zhixiong |
| description | Primary central nervous system (CNS) extranodal NK/T-cell lymphoma, nasal type (NKTCL), is an extremely rare tumor. To the best of our knowledge, only four cases have been described previously. Here, we report a case of primary CNS NKTCL in a 25-year-old immunocompetent Chinese male. The patient presented with worsening dizziness, headaches, and vomiting for approximately 2 weeks. Magnetic resonance imaging demonstrated three masses with solid components entirely in the parenchyma of the right hemisphere, and no sinonasal/nasopharyngeal lesions were found. The patient underwent a partial resection of the right temporal mass. Histological examination revealed that intermediate-sized, pleomorphic lymphocytes were arranged in an angiocentric distribution with large geographic necroses. The tumor cells expressed CD3ε, CD56, TIA-1, granzyme B, and Epstein−Barr virus-encoded RNAs. A rearrangement study showed T-cell receptor γ-chain gene rearrangement with monoclonal appearance. Postoperative chemotherapy and radiotherapy were also given, but the lymphoma failed to respond to therapy and the patient died 18 months later. Our observation and the four others found in the literature indicate that primary CNS NKTCL occurs predominantly in adult males. This is the youngest patient with primary CNS NKTCL reported. |
| doi_str_mv | 10.1007/s11060-010-0384-5 |
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To the best of our knowledge, only four cases have been described previously. Here, we report a case of primary CNS NKTCL in a 25-year-old immunocompetent Chinese male. The patient presented with worsening dizziness, headaches, and vomiting for approximately 2 weeks. Magnetic resonance imaging demonstrated three masses with solid components entirely in the parenchyma of the right hemisphere, and no sinonasal/nasopharyngeal lesions were found. The patient underwent a partial resection of the right temporal mass. Histological examination revealed that intermediate-sized, pleomorphic lymphocytes were arranged in an angiocentric distribution with large geographic necroses. The tumor cells expressed CD3ε, CD56, TIA-1, granzyme B, and Epstein−Barr virus-encoded RNAs. A rearrangement study showed T-cell receptor γ-chain gene rearrangement with monoclonal appearance. Postoperative chemotherapy and radiotherapy were also given, but the lymphoma failed to respond to therapy and the patient died 18 months later. Our observation and the four others found in the literature indicate that primary CNS NKTCL occurs predominantly in adult males. This is the youngest patient with primary CNS NKTCL reported.</description><identifier>ISSN: 0167-594X</identifier><identifier>EISSN: 1573-7373</identifier><identifier>DOI: 10.1007/s11060-010-0384-5</identifier><identifier>PMID: 20845062</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Antineoplastic Agents - therapeutic use ; Brain Neoplasms - genetics ; Brain Neoplasms - pathology ; Brain Neoplasms - therapy ; Case Report ; Combined Modality Therapy ; Fatal Outcome ; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor ; Herpesvirus 4, Human - genetics ; Humans ; Lymphoma, Extranodal NK-T-Cell - genetics ; Lymphoma, Extranodal NK-T-Cell - pathology ; Lymphoma, Extranodal NK-T-Cell - therapy ; Male ; Medicine ; Medicine & Public Health ; Neurology ; Oncology ; Radiotherapy ; RNA, Viral - isolation & purification</subject><ispartof>Journal of neuro-oncology, 2011-06, Vol.103 (2), p.387-391</ispartof><rights>Springer Science+Business Media, LLC. 2010</rights><rights>Springer Science+Business Media, LLC. 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-20007ceb01ec462721256bd004bbc6573d3ccb42c59e31e84ecd42cc83fd5bd63</citedby><cites>FETCH-LOGICAL-c402t-20007ceb01ec462721256bd004bbc6573d3ccb42c59e31e84ecd42cc83fd5bd63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11060-010-0384-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11060-010-0384-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20845062$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guan, Hong</creatorcontrib><creatorcontrib>Huang, Yuhua</creatorcontrib><creatorcontrib>Wen, Wen</creatorcontrib><creatorcontrib>Xu, Meiquan</creatorcontrib><creatorcontrib>Zan, Qin</creatorcontrib><creatorcontrib>Zhang, Zhixiong</creatorcontrib><title>Primary central nervous system extranodal NK/T-cell lymphoma, nasal type: case report and review of the literature</title><title>Journal of neuro-oncology</title><addtitle>J Neurooncol</addtitle><addtitle>J Neurooncol</addtitle><description>Primary central nervous system (CNS) extranodal NK/T-cell lymphoma, nasal type (NKTCL), is an extremely rare tumor. To the best of our knowledge, only four cases have been described previously. Here, we report a case of primary CNS NKTCL in a 25-year-old immunocompetent Chinese male. The patient presented with worsening dizziness, headaches, and vomiting for approximately 2 weeks. Magnetic resonance imaging demonstrated three masses with solid components entirely in the parenchyma of the right hemisphere, and no sinonasal/nasopharyngeal lesions were found. The patient underwent a partial resection of the right temporal mass. Histological examination revealed that intermediate-sized, pleomorphic lymphocytes were arranged in an angiocentric distribution with large geographic necroses. The tumor cells expressed CD3ε, CD56, TIA-1, granzyme B, and Epstein−Barr virus-encoded RNAs. A rearrangement study showed T-cell receptor γ-chain gene rearrangement with monoclonal appearance. Postoperative chemotherapy and radiotherapy were also given, but the lymphoma failed to respond to therapy and the patient died 18 months later. Our observation and the four others found in the literature indicate that primary CNS NKTCL occurs predominantly in adult males. This is the youngest patient with primary CNS NKTCL reported.</description><subject>Adult</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - therapy</subject><subject>Case Report</subject><subject>Combined Modality Therapy</subject><subject>Fatal Outcome</subject><subject>Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor</subject><subject>Herpesvirus 4, Human - genetics</subject><subject>Humans</subject><subject>Lymphoma, Extranodal NK-T-Cell - genetics</subject><subject>Lymphoma, Extranodal NK-T-Cell - pathology</subject><subject>Lymphoma, Extranodal NK-T-Cell - therapy</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Oncology</subject><subject>Radiotherapy</subject><subject>RNA, Viral - isolation & purification</subject><issn>0167-594X</issn><issn>1573-7373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkctu1TAQhi0Eak8LD9ANstiwaej4EjthV1X0IipgUSR2luPMaU-VG7ZTOG_PHKUFCQmxsOzxfDOe3z9jRwLeCQB7koQAAwUIWqrSRfmMrURpVWGVVc_ZCoSxRVnrb_vsIKV7ANBWiT22L6HSJRi5YvFL3PQ-bnnAIUff8QHjwzgnnrYpY8_xJ90OY0uZTx9PboqAXce7bT_djb0_5oNPlMnbCd_z4BPyiNMYM_dDS8eHDf7g45rnO-TdJmP0eY74kr1Y-y7hq8f9kH09_3Bzdllcf764Oju9LoIGmQtJ49qADQgM2kgrhSxN05KGpgmGVLYqhEbLUNaoBFYaQ0tRqNS6LZvWqEP2duk7xfH7jCm7fpN28_sBSaGrrJHK1rb-P2kqkJXQQOSbv8j7cY4DySDI6lqCkASJBQpxTCni2k3LJzsBbmecW4xzZJzbGedKqnn92Hhuemx_Vzw5RYBcgESp4Rbjn5f_3fUX4W2jgw</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Guan, Hong</creator><creator>Huang, Yuhua</creator><creator>Wen, Wen</creator><creator>Xu, Meiquan</creator><creator>Zan, Qin</creator><creator>Zhang, Zhixiong</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20110601</creationdate><title>Primary central nervous system extranodal NK/T-cell lymphoma, nasal type: case report and review of the literature</title><author>Guan, Hong ; Huang, Yuhua ; Wen, Wen ; Xu, Meiquan ; Zan, Qin ; Zhang, Zhixiong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-20007ceb01ec462721256bd004bbc6573d3ccb42c59e31e84ecd42cc83fd5bd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Brain Neoplasms - genetics</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain Neoplasms - therapy</topic><topic>Case Report</topic><topic>Combined Modality Therapy</topic><topic>Fatal Outcome</topic><topic>Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor</topic><topic>Herpesvirus 4, Human - genetics</topic><topic>Humans</topic><topic>Lymphoma, Extranodal NK-T-Cell - genetics</topic><topic>Lymphoma, Extranodal NK-T-Cell - pathology</topic><topic>Lymphoma, Extranodal NK-T-Cell - therapy</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Oncology</topic><topic>Radiotherapy</topic><topic>RNA, Viral - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guan, Hong</creatorcontrib><creatorcontrib>Huang, Yuhua</creatorcontrib><creatorcontrib>Wen, Wen</creatorcontrib><creatorcontrib>Xu, Meiquan</creatorcontrib><creatorcontrib>Zan, Qin</creatorcontrib><creatorcontrib>Zhang, Zhixiong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuro-oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guan, Hong</au><au>Huang, Yuhua</au><au>Wen, Wen</au><au>Xu, Meiquan</au><au>Zan, Qin</au><au>Zhang, Zhixiong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary central nervous system extranodal NK/T-cell lymphoma, nasal type: case report and review of the literature</atitle><jtitle>Journal of neuro-oncology</jtitle><stitle>J Neurooncol</stitle><addtitle>J Neurooncol</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>103</volume><issue>2</issue><spage>387</spage><epage>391</epage><pages>387-391</pages><issn>0167-594X</issn><eissn>1573-7373</eissn><abstract>Primary central nervous system (CNS) extranodal NK/T-cell lymphoma, nasal type (NKTCL), is an extremely rare tumor. To the best of our knowledge, only four cases have been described previously. Here, we report a case of primary CNS NKTCL in a 25-year-old immunocompetent Chinese male. The patient presented with worsening dizziness, headaches, and vomiting for approximately 2 weeks. Magnetic resonance imaging demonstrated three masses with solid components entirely in the parenchyma of the right hemisphere, and no sinonasal/nasopharyngeal lesions were found. The patient underwent a partial resection of the right temporal mass. Histological examination revealed that intermediate-sized, pleomorphic lymphocytes were arranged in an angiocentric distribution with large geographic necroses. The tumor cells expressed CD3ε, CD56, TIA-1, granzyme B, and Epstein−Barr virus-encoded RNAs. A rearrangement study showed T-cell receptor γ-chain gene rearrangement with monoclonal appearance. Postoperative chemotherapy and radiotherapy were also given, but the lymphoma failed to respond to therapy and the patient died 18 months later. Our observation and the four others found in the literature indicate that primary CNS NKTCL occurs predominantly in adult males. This is the youngest patient with primary CNS NKTCL reported.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>20845062</pmid><doi>10.1007/s11060-010-0384-5</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Antineoplastic Agents - therapeutic use Brain Neoplasms - genetics Brain Neoplasms - pathology Brain Neoplasms - therapy Case Report Combined Modality Therapy Fatal Outcome Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor Herpesvirus 4, Human - genetics Humans Lymphoma, Extranodal NK-T-Cell - genetics Lymphoma, Extranodal NK-T-Cell - pathology Lymphoma, Extranodal NK-T-Cell - therapy Male Medicine Medicine & Public Health Neurology Oncology Radiotherapy RNA, Viral - isolation & purification |
| title | Primary central nervous system extranodal NK/T-cell lymphoma, nasal type: case report and review of the literature |
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