Enhanced metaboreflex sensitivity in hypertensive humans
The exercise pressor reflex (EPR) is composed of the mechanoreflex and the metaboreflex and has been shown to be overactive in spontaneously hypertensive rats. The aim of the present study was to isolate the metaboreflex using post-exercise ischemia (PEI) and examine the BP response in normotensive...
Gespeichert in:
| Veröffentlicht in: | European journal of applied physiology 2009-02, Vol.105 (3), p.351-356 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 356 |
|---|---|
| container_issue | 3 |
| container_start_page | 351 |
| container_title | European journal of applied physiology |
| container_volume | 105 |
| creator | Sausen, M. T. Delaney, E. P. Stillabower, M. E. Farquhar, William B. |
| description | The exercise pressor reflex (EPR) is composed of the mechanoreflex and the metaboreflex and has been shown to be overactive in spontaneously hypertensive rats. The aim of the present study was to isolate the metaboreflex using post-exercise ischemia (PEI) and examine the BP response in normotensive (NTN) and hypertensive (HTN) humans. We hypothesize that the post-exercise ischemia-induced maintenance of BP will be greater in HTN when compared to NTN adults. A total of 15 NTN (65 ± 1 years) and 12 HTN (64 ± 1 years) adults were recruited. Beat-to-beat mean arterial pressure (MAP) was measured non-invasively (Finometer). Dynamic handgrip exercise (DHE) was performed for 3 min followed by 2 min of PEI. An unpaired
t
test was used to examine differences between groups. As compared to resting baseline values, the change in MAP during PEI was greater in HTN than NTN subjects (HTN: Δ = 12 ± 3 mmHg, NTN: Δ = 6 ± 1 mmHg,
P
|
| doi_str_mv | 10.1007/s00421-008-0910-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_876237193</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1896055081</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-3652d6582a484f700d1d527ffa071829b1722c1135d04a600583b896ad044aa83</originalsourceid><addsrcrecordid>eNp9kFtLwzAYhoMobk5_gDdSBPWq-n1J2iSXMuYBBt7odcja1HX0MJN2uH9vxsYGgl7l9OTNm4eQS4R7BBAPHoBTjAFkDAohlkdkiJypOGVUHO_nqAbkzPsFBJCiPCUDlEqqVPEhkZNmbprM5lFtOzNrnS0q-x152_iyK1dlt47KJpqvl9Z1m72VjeZ9bRp_Tk4KU3l7sRtH5ONp8j5-iadvz6_jx2mccYZdzNKE5mkiqeGSFwIgxzyhoigMCJRUzVBQmiGyJAduUoBEslnoZsKSGyPZiNxtc5eu_eqt73Rd-sxWlWls23stRUqZQMUCefsvmaaSJRJFAK9_gYu2d034habAqAppNEC4hTLXeh-06KUra-PWGkFv7OutfR2k6o19vel6tQvuZ7XNDzd2ugNwswOMz0xVuKC-9HuOInCAIGNE6Jbz4aj5tO7Q8O_XfwAtRZnF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>203297192</pqid></control><display><type>article</type><title>Enhanced metaboreflex sensitivity in hypertensive humans</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Sausen, M. T. ; Delaney, E. P. ; Stillabower, M. E. ; Farquhar, William B.</creator><creatorcontrib>Sausen, M. T. ; Delaney, E. P. ; Stillabower, M. E. ; Farquhar, William B.</creatorcontrib><description>The exercise pressor reflex (EPR) is composed of the mechanoreflex and the metaboreflex and has been shown to be overactive in spontaneously hypertensive rats. The aim of the present study was to isolate the metaboreflex using post-exercise ischemia (PEI) and examine the BP response in normotensive (NTN) and hypertensive (HTN) humans. We hypothesize that the post-exercise ischemia-induced maintenance of BP will be greater in HTN when compared to NTN adults. A total of 15 NTN (65 ± 1 years) and 12 HTN (64 ± 1 years) adults were recruited. Beat-to-beat mean arterial pressure (MAP) was measured non-invasively (Finometer). Dynamic handgrip exercise (DHE) was performed for 3 min followed by 2 min of PEI. An unpaired
t
test was used to examine differences between groups. As compared to resting baseline values, the change in MAP during PEI was greater in HTN than NTN subjects (HTN: Δ = 12 ± 3 mmHg, NTN: Δ = 6 ± 1 mmHg,
P
< 0.05). These data suggest that HTN humans have enhanced metaboreflex sensitivity.</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-008-0910-8</identifier><identifier>PMID: 18989694</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Afferent Pathways - physiology ; Aged ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Blood Pressure ; Cardiovascular disease ; Exercise ; Exercise - physiology ; Exercise Test ; Feedback - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Hand Strength ; Heart rate ; Human Physiology ; Humans ; Hypertension ; Hypertension - metabolism ; Hypertension - physiopathology ; Ischemia ; Ischemia - metabolism ; Ischemia - physiopathology ; Male ; Middle Aged ; Musculoskeletal system ; Nervous system ; Occupational Medicine/Industrial Medicine ; Original Article ; Physical fitness ; Pressoreceptors ; Questionnaires ; Reflex - physiology ; Sports Medicine ; Vein & artery diseases ; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><ispartof>European journal of applied physiology, 2009-02, Vol.105 (3), p.351-356</ispartof><rights>Springer-Verlag 2008</rights><rights>2009 INIST-CNRS</rights><rights>Springer-Verlag 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-3652d6582a484f700d1d527ffa071829b1722c1135d04a600583b896ad044aa83</citedby><cites>FETCH-LOGICAL-c431t-3652d6582a484f700d1d527ffa071829b1722c1135d04a600583b896ad044aa83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00421-008-0910-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00421-008-0910-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21040011$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18989694$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sausen, M. T.</creatorcontrib><creatorcontrib>Delaney, E. P.</creatorcontrib><creatorcontrib>Stillabower, M. E.</creatorcontrib><creatorcontrib>Farquhar, William B.</creatorcontrib><title>Enhanced metaboreflex sensitivity in hypertensive humans</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><addtitle>Eur J Appl Physiol</addtitle><description>The exercise pressor reflex (EPR) is composed of the mechanoreflex and the metaboreflex and has been shown to be overactive in spontaneously hypertensive rats. The aim of the present study was to isolate the metaboreflex using post-exercise ischemia (PEI) and examine the BP response in normotensive (NTN) and hypertensive (HTN) humans. We hypothesize that the post-exercise ischemia-induced maintenance of BP will be greater in HTN when compared to NTN adults. A total of 15 NTN (65 ± 1 years) and 12 HTN (64 ± 1 years) adults were recruited. Beat-to-beat mean arterial pressure (MAP) was measured non-invasively (Finometer). Dynamic handgrip exercise (DHE) was performed for 3 min followed by 2 min of PEI. An unpaired
t
test was used to examine differences between groups. As compared to resting baseline values, the change in MAP during PEI was greater in HTN than NTN subjects (HTN: Δ = 12 ± 3 mmHg, NTN: Δ = 6 ± 1 mmHg,
P
< 0.05). These data suggest that HTN humans have enhanced metaboreflex sensitivity.</description><subject>Afferent Pathways - physiology</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood Pressure</subject><subject>Cardiovascular disease</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Exercise Test</subject><subject>Feedback - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hand Strength</subject><subject>Heart rate</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - metabolism</subject><subject>Hypertension - physiopathology</subject><subject>Ischemia</subject><subject>Ischemia - metabolism</subject><subject>Ischemia - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Musculoskeletal system</subject><subject>Nervous system</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Physical fitness</subject><subject>Pressoreceptors</subject><subject>Questionnaires</subject><subject>Reflex - physiology</subject><subject>Sports Medicine</subject><subject>Vein & artery diseases</subject><subject>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kFtLwzAYhoMobk5_gDdSBPWq-n1J2iSXMuYBBt7odcja1HX0MJN2uH9vxsYGgl7l9OTNm4eQS4R7BBAPHoBTjAFkDAohlkdkiJypOGVUHO_nqAbkzPsFBJCiPCUDlEqqVPEhkZNmbprM5lFtOzNrnS0q-x152_iyK1dlt47KJpqvl9Z1m72VjeZ9bRp_Tk4KU3l7sRtH5ONp8j5-iadvz6_jx2mccYZdzNKE5mkiqeGSFwIgxzyhoigMCJRUzVBQmiGyJAduUoBEslnoZsKSGyPZiNxtc5eu_eqt73Rd-sxWlWls23stRUqZQMUCefsvmaaSJRJFAK9_gYu2d034habAqAppNEC4hTLXeh-06KUra-PWGkFv7OutfR2k6o19vel6tQvuZ7XNDzd2ugNwswOMz0xVuKC-9HuOInCAIGNE6Jbz4aj5tO7Q8O_XfwAtRZnF</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Sausen, M. T.</creator><creator>Delaney, E. P.</creator><creator>Stillabower, M. E.</creator><creator>Farquhar, William B.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7TS</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20090201</creationdate><title>Enhanced metaboreflex sensitivity in hypertensive humans</title><author>Sausen, M. T. ; Delaney, E. P. ; Stillabower, M. E. ; Farquhar, William B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-3652d6582a484f700d1d527ffa071829b1722c1135d04a600583b896ad044aa83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Afferent Pathways - physiology</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood Pressure</topic><topic>Cardiovascular disease</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Exercise Test</topic><topic>Feedback - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hand Strength</topic><topic>Heart rate</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - metabolism</topic><topic>Hypertension - physiopathology</topic><topic>Ischemia</topic><topic>Ischemia - metabolism</topic><topic>Ischemia - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Musculoskeletal system</topic><topic>Nervous system</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Physical fitness</topic><topic>Pressoreceptors</topic><topic>Questionnaires</topic><topic>Reflex - physiology</topic><topic>Sports Medicine</topic><topic>Vein & artery diseases</topic><topic>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sausen, M. T.</creatorcontrib><creatorcontrib>Delaney, E. P.</creatorcontrib><creatorcontrib>Stillabower, M. E.</creatorcontrib><creatorcontrib>Farquhar, William B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sausen, M. T.</au><au>Delaney, E. P.</au><au>Stillabower, M. E.</au><au>Farquhar, William B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced metaboreflex sensitivity in hypertensive humans</atitle><jtitle>European journal of applied physiology</jtitle><stitle>Eur J Appl Physiol</stitle><addtitle>Eur J Appl Physiol</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>105</volume><issue>3</issue><spage>351</spage><epage>356</epage><pages>351-356</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>The exercise pressor reflex (EPR) is composed of the mechanoreflex and the metaboreflex and has been shown to be overactive in spontaneously hypertensive rats. The aim of the present study was to isolate the metaboreflex using post-exercise ischemia (PEI) and examine the BP response in normotensive (NTN) and hypertensive (HTN) humans. We hypothesize that the post-exercise ischemia-induced maintenance of BP will be greater in HTN when compared to NTN adults. A total of 15 NTN (65 ± 1 years) and 12 HTN (64 ± 1 years) adults were recruited. Beat-to-beat mean arterial pressure (MAP) was measured non-invasively (Finometer). Dynamic handgrip exercise (DHE) was performed for 3 min followed by 2 min of PEI. An unpaired
t
test was used to examine differences between groups. As compared to resting baseline values, the change in MAP during PEI was greater in HTN than NTN subjects (HTN: Δ = 12 ± 3 mmHg, NTN: Δ = 6 ± 1 mmHg,
P
< 0.05). These data suggest that HTN humans have enhanced metaboreflex sensitivity.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>18989694</pmid><doi>10.1007/s00421-008-0910-8</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1439-6319 |
| ispartof | European journal of applied physiology, 2009-02, Vol.105 (3), p.351-356 |
| issn | 1439-6319 1439-6327 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_876237193 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Afferent Pathways - physiology Aged Biological and medical sciences Biomedical and Life Sciences Biomedicine Blood Pressure Cardiovascular disease Exercise Exercise - physiology Exercise Test Feedback - physiology Female Fundamental and applied biological sciences. Psychology Hand Strength Heart rate Human Physiology Humans Hypertension Hypertension - metabolism Hypertension - physiopathology Ischemia Ischemia - metabolism Ischemia - physiopathology Male Middle Aged Musculoskeletal system Nervous system Occupational Medicine/Industrial Medicine Original Article Physical fitness Pressoreceptors Questionnaires Reflex - physiology Sports Medicine Vein & artery diseases Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports |
| title | Enhanced metaboreflex sensitivity in hypertensive humans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T12%3A42%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Enhanced%20metaboreflex%20sensitivity%20in%20hypertensive%20humans&rft.jtitle=European%20journal%20of%20applied%20physiology&rft.au=Sausen,%20M.%20T.&rft.date=2009-02-01&rft.volume=105&rft.issue=3&rft.spage=351&rft.epage=356&rft.pages=351-356&rft.issn=1439-6319&rft.eissn=1439-6327&rft_id=info:doi/10.1007/s00421-008-0910-8&rft_dat=%3Cproquest_cross%3E1896055081%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=203297192&rft_id=info:pmid/18989694&rfr_iscdi=true |