Towards systematic functional characterization of cancer genomes

Key Points Cancer genome characterization efforts will provide a complete description of genetic and epigenetic alterations in cancer. However, the complexity and heterogeneity of cancer genomes makes it clear that complementary efforts to understand the function of cancer genes are necessary. The t...

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Veröffentlicht in:	Nature reviews. Genetics 2011-07, Vol.12 (7), p.487-498
Hauptverfasser:	Boehm, Jesse S., Hahn, William C.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/514/1948 68 69 Agriculture Algorithms Animal Genetics and Genomics Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Cancer Research Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Databases, Genetic - trends DNA sequencing Epigenetics Fundamental and applied biological sciences. Psychology Gene expression Gene Function Gene mutations Genetic aspects Genetic engineering Genetics of eukaryotes. Biological and molecular evolution Genome, Human - genetics Genome, Human - physiology Genomes Genomics Genomics - trends Health aspects Human Genetics Humans Kinases MicroRNAs Models, Biological Molecular and cellular biology Mutation Neoplasms - genetics Nucleotide sequencing Research Design - trends review-article Tumors
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