Ternary complexes of amphiphilic polycaprolactone-graft-poly (N,N-dimethylaminoethyl methacrylate), DNA and polyglutamic acid-graft-poly(ethylene glycol) for gene delivery

Abstract Binary complexes of cationic polymers and DNA were used commonly for DNA delivery, whereas, the excess cationic charge of the binary complexes mainly leads to high toxicity and unstability in vivo . In this paper, ternary complexes by coating polyglutamic acid-graft-poly(ethylene glycol)(PG...

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Veröffentlicht in:	Biomaterials 2011-06, Vol.32 (18), p.4283-4292
Hauptverfasser:	Guo, Shutao, Huang, Yuanyu, Zhang, Wendi, Wang, Weiwei, Wei, Tuo, Lin, Daoshu, Xing, Jinfeng, Deng, Liandong, Du, Quan, Liang, Zicai, Liang, Xing-Jie, Dong, Anjie
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Amphiphilic copolymers Animals Dentistry DNA - chemistry Gene delivery Gene Transfer Techniques Genetic Therapy - methods HeLa Cells Humans Methacrylates - chemistry Mice Mice, Nude Models, Molecular Nanoparticles - chemistry Particle Size PCL-g-PDMAEMA Polyesters - chemistry Polyethylene Glycols - chemistry Polyglutamic Acid - chemistry Sincalide - metabolism Ternary complexes Tumor target
Online-Zugang:	Volltext
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