Effect of polysaccharide nanocrystals on structure, properties, and drug release kinetics of alginate-based microspheres

[Display omitted] ► Polysaccharide nanocrystals were firstly introduced into alginate microspheres. ► Mechanical strength and drug release behavior were enhanced and regulated. ► Nanocrystals increased the stability of the crosslinked network structure. ► Release kinetics and transport mechanisms we...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2011-07, Vol.85 (2), p.270-279
Hauptverfasser:	Lin, Ning, Huang, Jin, Chang, Peter R., Feng, Liangdong, Yu, Jiahui
Format:	Artikel
Sprache:	eng
Schlagworte:	Alginate Alginates - chemistry cellulose chitin colloids crosslinking Drug Delivery Systems - methods Drug Stability Drugs electron microscopy Fourier transform infrared spectroscopy Glucuronic Acid - chemistry Hexuronic Acids - chemistry Kinetics Microscopy, Electron, Scanning Microspheres Nanocomposites Nanocomposites - chemistry Nanocomposites - ultrastructure Nanocrystals Nanomaterials Nanoparticles - chemistry Nanoparticles - ultrastructure Nanostructure physiological transport Polysaccharide nanocrystals Polysaccharides Polysaccharides - chemistry Release kinetics Scanning electron microscopy Spectroscopy, Fourier Transform Infrared starch theophylline Theophylline - administration & dosage Theophylline - chemistry Theophylline - pharmacokinetics Vasodilator Agents - administration & dosage Vasodilator Agents - chemistry Vasodilator Agents - pharmacokinetics X-Ray Diffraction
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