Initial PET studies in rats with novel radiotracer [11C]D617 and comparison with (R)-[11C]verapamil
The aim of this study is to develop the synthesis of [11C]D617 and to study its brain distribution in rats with and without pre-treatment with P-gp inhibitor tariquidar and compare the results with previous data obtained with (R)-[11C]verapamil. The precursor for labelling D617 with C-11, compound 5...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2010-08, Vol.52 (S1), p.S26-S26 |
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| container_title | NeuroImage (Orlando, Fla.) |
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| creator | Verbeek, J. Syvänen, S. Luurtsema, G. de Lange, E.C. Eriksson, J. Windhorst, A.D. Lammertsma, A.A. |
| description | The aim of this study is to develop the synthesis of [11C]D617 and to study its brain distribution in rats with and without pre-treatment with P-gp inhibitor tariquidar and compare the results with previous data obtained with (R)-[11C]verapamil. The precursor for labelling D617 with C-11, compound 5, was synthesized in 4 steps and subsequently reacted with [11C]methyl triflate to give [11C]D617. a: DMF, NaH, isopropyl bromide, RT, 5h, 77%; b: THF, n-BuLi, 1,3-dibromopropane -78°C, 2h, 83%; c: toluene, 18-Crown-6, potassium phtalimide, reflux 6h, 86%; d: THF, EtOH, hydrazine.H2O, RT, 2h, 74%; e: methylamine, toluene/H2O, 56%. |
| doi_str_mv | 10.1016/j.neuroimage.2010.04.210 |
| format | Article |
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| title | Initial PET studies in rats with novel radiotracer [11C]D617 and comparison with (R)-[11C]verapamil |
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